STRINGSTRING
MBTPS2 MBTPS2 COL2A1 COL2A1 PPIB PPIB BMP6 BMP6 TFAP2A TFAP2A LEPR LEPR SP5 SP5 INSIG2 INSIG2 EXT1 EXT1 PAX1 PAX1 DLX5 DLX5 TRIM45 TRIM45 TNFSF11 TNFSF11 NAB2 NAB2 CCN4 CCN4 BMPR1B BMPR1B M3XSY7_MUSPF M3XSY7_MUSPF M3XSY8_MUSPF M3XSY8_MUSPF PTPN11 PTPN11 RAB23 RAB23 IFT80 IFT80 ACTN3 ACTN3 TMEM119 TMEM119 OSTN OSTN DDR2 DDR2 TRPV4 TRPV4 BNC2 BNC2 M3XY99_MUSPF M3XY99_MUSPF M3XYC1_MUSPF M3XYC1_MUSPF MEF2D MEF2D LRP5 LRP5 COL13A1 COL13A1 FGF4 FGF4 BGLAP BGLAP SNX10 SNX10 ECM1 ECM1 OGN OGN HOXA11 HOXA11 NPPC NPPC PAPPA2 PAPPA2 BMP4 BMP4 NPR2 NPR2 THBS3 THBS3 M3Y3R7_MUSPF M3Y3R7_MUSPF EXT2 EXT2 RARG RARG KIT KIT BMP2 BMP2 LEP LEP MMP13 MMP13 SMAD1 SMAD1 SLC10A7 SLC10A7 TMEM38B TMEM38B MMP14 MMP14 CYP26B1 CYP26B1 EPYC EPYC ANKRD11 ANKRD11 MEGF8 MEGF8 TRIP11 TRIP11 EVC EVC MSX1 MSX1 MEF2C MEF2C CTC1 CTC1 TMEM107 TMEM107 FOXN3 FOXN3 M3YA03_MUSPF M3YA03_MUSPF SEMA4D SEMA4D IFITM5 IFITM5 PITX2 PITX2 FLI1 FLI1 TP53 TP53 SERPINH1 SERPINH1 TULP3 TULP3 ATP6AP1 ATP6AP1 INSIG1 INSIG1 M3YE56_MUSPF M3YE56_MUSPF BBX BBX SMAD5 SMAD5 TIFAB TIFAB GLG1 GLG1 M3YFG7_MUSPF M3YFG7_MUSPF IMPAD1 IMPAD1 PTPRC PTPRC SULF1 SULF1 M3YHM6_MUSPF M3YHM6_MUSPF M3YHN0_MUSPF M3YHN0_MUSPF M3YHN1_MUSPF M3YHN1_MUSPF M3YHN2_MUSPF M3YHN2_MUSPF MMP16 MMP16 NSD2 NSD2 MPIG6B MPIG6B NOTUM NOTUM SPNS2 SPNS2 SLC38A10 SLC38A10 LTBP3 LTBP3 IGF1 IGF1 PIP4K2A PIP4K2A RARB RARB ABI1 ABI1 COL3A1 COL3A1 TAL1 TAL1 M3YM13_MUSPF M3YM13_MUSPF RUNX2 RUNX2 SCUBE2 SCUBE2 SH3PXD2B SH3PXD2B CSGALNACT1 CSGALNACT1 FGF18 FGF18 PAFAH1B1 PAFAH1B1 MIGA2 MIGA2 SRF SRF M3YQ96_MUSPF M3YQ96_MUSPF ANXA6 ANXA6 P3H1 P3H1 CDX1 CDX1 ATF2 ATF2 ZMPSTE24 ZMPSTE24 SOX9 SOX9 MAP2K6 MAP2K6 AXIN2 AXIN2 WNT1 WNT1 PEX7 PEX7 M3YU90_MUSPF M3YU90_MUSPF RANBP3L RANBP3L LTF LTF OSR2 OSR2 HOXB4 HOXB4 PHOSPHO1 PHOSPHO1 MATN1 MATN1 CHAD CHAD COMP COMP WASF2 WASF2 CCDC154 CCDC154 M3YW95_MUSPF M3YW95_MUSPF M3YW97_MUSPF M3YW97_MUSPF ALPL ALPL BGN BGN SBDS SBDS DHRS3 DHRS3 EP300 EP300 M3YYR0_MUSPF M3YYR0_MUSPF PTPN6 PTPN6 PAPSS2 PAPSS2 FOXP1 FOXP1 PLS3 PLS3 SULF2 SULF2 TGM2 TGM2 SRC SRC ASXL1 ASXL1 GLI3 GLI3 SFRP4 SFRP4 LRRC17 LRRC17 M3Z4C1_MUSPF M3Z4C1_MUSPF AMER1 AMER1 CITED2 CITED2 PHOSPHO2 PHOSPHO2 GPR68 GPR68 NEUROG1 NEUROG1 GP9 GP9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MBTPS2Membrane bound transcription factor peptidase, site 2. (604 aa)
COL2A1Collagen type II alpha 1 chain. (1486 aa)
PPIBPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
BMP6Bone morphogenetic protein 6. (426 aa)
TFAP2ATranscription factor AP-2 alpha. (384 aa)
LEPRLeptin receptor. (1164 aa)
SP5Sp5 transcription factor. (397 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
PAX1Paired box 1. (452 aa)
DLX5Distal-less homeobox 5. (289 aa)
TRIM45Tripartite motif containing 45. (486 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
NAB2NGFI-A binding protein 2. (525 aa)
CCN4Cellular communication network factor 4. (367 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (514 aa)
M3XSY7_MUSPFUncharacterized protein. (242 aa)
M3XSY8_MUSPFUncharacterized protein. (300 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
RAB23RAB23, member RAS oncogene family. (238 aa)
IFT80Intraflagellar transport 80. (766 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (904 aa)
TMEM119Transmembrane protein 119. (254 aa)
OSTNOsteocrin. (132 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (924 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (873 aa)
BNC2Basonuclin 2. (1085 aa)
M3XY99_MUSPFUncharacterized protein. (1418 aa)
M3XYC1_MUSPFUncharacterized protein. (107 aa)
MEF2DMyocyte enhancer factor 2D. (454 aa)
LRP5Uncharacterized protein. (1465 aa)
COL13A1Collagen type XIII alpha 1 chain. (765 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
BGLAPOsteocalcin; Binds strongly to apatite and calcium. (100 aa)
SNX10Sorting nexin 10. (201 aa)
ECM1Extracellular matrix protein 1. (564 aa)
OGNOsteoglycin. (298 aa)
HOXA11Homeobox A11. (269 aa)
NPPCNatriuretic peptide C. (126 aa)
PAPPA2Pappalysin 2. (1785 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
NPR2Guanylate cyclase. (926 aa)
THBS3Thrombospondin 3. (956 aa)
M3Y3R7_MUSPFUncharacterized protein. (144 aa)
EXT2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (760 aa)
RARGRetinoic acid receptor gamma. (458 aa)
KITKIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (948 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
MMP13Matrix metallopeptidase 13. (511 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
SLC10A7Sodium/bile acid cotransporter; Does not show transport activity towards bile acids or steroid sulfates; Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. (340 aa)
TMEM38BTransmembrane protein 38B. (291 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
EPYCEpiphycan. (321 aa)
ANKRD11Ankyrin repeat domain 11. (2631 aa)
MEGF8Multiple EGF like domains 8. (2396 aa)
TRIP11Thyroid hormone receptor interactor 11. (1977 aa)
EVCEvC ciliary complex subunit 1. (993 aa)
MSX1Msh homeobox 1. (303 aa)
MEF2CMyocyte enhancer factor 2C. (433 aa)
CTC1CST telomere replication complex component 1. (1216 aa)
TMEM107Transmembrane protein 107. (131 aa)
FOXN3Forkhead box N3. (515 aa)
M3YA03_MUSPFUncharacterized protein. (666 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (857 aa)
IFITM5Interferon induced transmembrane protein 5. (134 aa)
PITX2Homeobox protein. (317 aa)
FLI1Fli-1 proto-oncogene, ETS transcription factor. (452 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
SERPINH1Serpin peptidase inhibitor, clade H, member 1; Belongs to the serpin family. (415 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (462 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (464 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (113 aa)
M3YE56_MUSPFCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (576 aa)
BBXBBX high mobility group box domain containing. (948 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
TIFABTIFA inhibitor. (211 aa)
GLG1Golgi glycoprotein 1. (957 aa)
M3YFG7_MUSPFUncharacterized protein. (135 aa)
IMPAD1Inositol monophosphatase domain containing 1. (294 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1298 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (867 aa)
M3YHM6_MUSPFANK_REP_REGION domain-containing protein. (264 aa)
M3YHN0_MUSPFUncharacterized protein. (221 aa)
M3YHN1_MUSPFRoc domain-containing protein. (313 aa)
M3YHN2_MUSPFProtein kinase domain-containing protein. (625 aa)
MMP16Matrix metallopeptidase 16. (562 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1344 aa)
MPIG6BMegakaryocyte and platelet inhibitory receptor G6b. (241 aa)
NOTUMNotum, palmitoleoyl-protein carboxylesterase. (434 aa)
SPNS2Sphingolipid transporter 2. (398 aa)
SLC38A10Solute carrier family 38 member 10. (1078 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1186 aa)
IGF1Insulin like growth factor 1. (153 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (368 aa)
RARBRetinoic acid receptor beta. (448 aa)
ABI1Abl interactor 1. (507 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (346 aa)
M3YM13_MUSPFUncharacterized protein. (437 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (507 aa)
SCUBE2Signal peptide, CUB domain and EGF like domain containing 2. (992 aa)
SH3PXD2BSH3 and PX domains 2B. (938 aa)
CSGALNACT1Hexosyltransferase. (410 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
MIGA2Mitoguardin 2. (593 aa)
SRFSerum response factor. (508 aa)
M3YQ96_MUSPFEXPERA domain-containing protein. (230 aa)
ANXA6Annexin. (673 aa)
P3H1Prolyl 3-hydroxylase 1. (735 aa)
CDX1Caudal type homeobox 1. (265 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
SOX9SRY-box transcription factor 9. (522 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
AXIN2Axin 2. (842 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (340 aa)
PEX7Peroxisomal biogenesis factor 7. (323 aa)
M3YU90_MUSPFMediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (616 aa)
RANBP3LRAN binding protein 3 like. (490 aa)
LTFLactotransferrin; Belongs to the transferrin family. (711 aa)
OSR2Odd-skipped related transciption factor 2. (276 aa)
HOXB4Homeobox B4. (251 aa)
PHOSPHO1Phosphoethanolamine/phosphocholine phosphatase. (305 aa)
MATN1Matrilin 1. (497 aa)
CHADChondroadherin. (359 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
WASF2WASP family member 2. (498 aa)
CCDC154Coiled-coil domain containing 154. (669 aa)
M3YW95_MUSPFUncharacterized protein. (139 aa)
M3YW97_MUSPFUncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (265 aa)
ALPLAlkaline phosphatase. (524 aa)
BGNBiglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (372 aa)
SBDSSBDS ribosome maturation factor. (174 aa)
DHRS3Dehydrogenase/reductase member 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
EP300E1A binding protein p300. (2425 aa)
M3YYR0_MUSPFAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (839 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
PAPSS23'-phosphoadenosine 5'-phosphosulfate synthase 2. (651 aa)
FOXP1Forkhead box P1. (676 aa)
PLS3Plastin 3. (651 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (954 aa)
TGM2Transglutaminase 2. (687 aa)
SRCTyrosine-protein kinase. (536 aa)
ASXL1ASXL transcriptional regulator 1. (1517 aa)
GLI3GLI family zinc finger 3. (1585 aa)
SFRP4Secreted frizzled related protein 4. (346 aa)
LRRC17Leucine rich repeat containing 17. (438 aa)
M3Z4C1_MUSPFUncharacterized protein. (550 aa)
AMER1APC membrane recruitment protein 1. (1134 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
PHOSPHO2Phosphatase, orphan 2. (241 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (360 aa)
NEUROG1Neurogenin 1. (247 aa)
GP9Glycoprotein IX platelet. (177 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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