(44 nodes) Cardiac septum morphogenesis network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MDM2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (247 aa)
	DHRS3	Dehydrogenase/reductase member 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
	MKS1	MKS transition zone complex subunit 1. (559 aa)
	TBX2	T-box transcription factor 2. (679 aa)
	DNAH11	Dynein axonemal heavy chain 11. (4511 aa)
	ENG	Endoglin. (653 aa)
	HAND1	Heart and neural crest derivatives expressed 1. (215 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	PARVA	Parvin alpha. (372 aa)
	SLIT3	Slit guidance ligand 3. (1391 aa)
	NKX2-5	NK2 homeobox 5. (323 aa)
	NOTCH1	Notch receptor 1. (2119 aa)
	NSD2	Nuclear receptor binding SET domain protein 2. (1344 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	M3YA03_MUSPF	Uncharacterized protein. (666 aa)
	TBX20	T-box transcription factor 20. (446 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (480 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	ZFPM2	Zinc finger protein, FOG family member 2. (1151 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (790 aa)
	GATA6	GATA binding protein 6. (482 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	CCN1	Cellular communication network factor 1. (382 aa)
	SAV1	Salvador family WW domain containing protein 1. (384 aa)
	HES1	Hes family bHLH transcription factor 1. (283 aa)
	TBX3	T-box transcription factor 3. (757 aa)
	TBX5	T-box transcription factor 5. (559 aa)
	CHD7	Chromodomain helicase DNA binding protein 7. (2522 aa)
	GATA4	GATA binding protein 4. (442 aa)
	NOTCH2	Notch receptor 2. (2471 aa)
	SMAD7	Mothers against decapentaplegic homolog. (426 aa)
	LRP2	LDL receptor related protein 2. (4699 aa)
	NRP2	Neuropilin; Belongs to the neuropilin family. (926 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1045 aa)
	SMAD6	Mothers against decapentaplegic homolog. (494 aa)
	FZD2	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (550 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
	APLNR	Apelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
	GJA5	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
	SEMA3C	Semaphorin 3C; Belongs to the semaphorin family. (750 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APLNR	GJA5	ENSMPUP00000018728	ENSMPUP00000018352	Apelin receptor; Belongs to the G-protein coupled receptor 1 family.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.526
BMP4	BMPR1A	ENSMPUP00000005423	ENSMPUP00000008777	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.997
BMP4	BMPR2	ENSMPUP00000005423	ENSMPUP00000000351	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.989
BMP4	FGF8	ENSMPUP00000005423	ENSMPUP00000016793	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.598
BMP4	GATA4	ENSMPUP00000005423	ENSMPUP00000001798	Bone morphogenetic protein 4.	GATA binding protein 4.	0.671
BMP4	GATA6	ENSMPUP00000005423	ENSMPUP00000005576	Bone morphogenetic protein 4.	GATA binding protein 6.	0.600
BMP4	JAG1	ENSMPUP00000005423	ENSMPUP00000006461	Bone morphogenetic protein 4.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.666
BMP4	NKX2-5	ENSMPUP00000005423	ENSMPUP00000012613	Bone morphogenetic protein 4.	NK2 homeobox 5.	0.436
BMP4	SMAD4	ENSMPUP00000005423	ENSMPUP00000008705	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.892
BMP4	SMAD6	ENSMPUP00000005423	ENSMPUP00000000305	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.721
BMP4	SMAD7	ENSMPUP00000005423	ENSMPUP00000000838	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.698
BMP4	TBX3	ENSMPUP00000005423	ENSMPUP00000002691	Bone morphogenetic protein 4.	T-box transcription factor 3.	0.482
BMP4	TBX5	ENSMPUP00000005423	ENSMPUP00000002687	Bone morphogenetic protein 4.	T-box transcription factor 5.	0.554
BMP4	TGFBR1	ENSMPUP00000005423	ENSMPUP00000006622	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.783
BMP4	WNT11	ENSMPUP00000005423	ENSMPUP00000008719	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.418
BMPR1A	BMP4	ENSMPUP00000008777	ENSMPUP00000005423	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.997
BMPR1A	BMPR2	ENSMPUP00000008777	ENSMPUP00000000351	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.969
BMPR1A	SMAD4	ENSMPUP00000008777	ENSMPUP00000008705	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.842
BMPR1A	SMAD6	ENSMPUP00000008777	ENSMPUP00000000305	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.826
BMPR1A	SMAD7	ENSMPUP00000008777	ENSMPUP00000000838	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.803