(28 nodes) Lung epithelium development network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NKX2-1	NK2 homeobox 1. (371 aa)
	FOXA1	Forkhead box A1. (501 aa)
	PKD1	Polycystin 1, transient receptor potential channel interacting. (4230 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	SOX9	SRY-box transcription factor 9. (522 aa)
	AGR2	Anterior gradient 2, protein disulphide isomerase family member. (175 aa)
	FOXJ1	Forkhead box J1. (421 aa)
	ADAMTSL2	ADAMTS like 2. (955 aa)
	THRB	Thyroid hormone receptor beta. (461 aa)
	KRAS	KRAS proto-oncogene, GTPase. (208 aa)
	YAP1	Yes associated protein 1. (325 aa)
	TMEM38B	Transmembrane protein 38B. (291 aa)
	WNT2	Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
	M3Y5C0_MUSPF	Uncharacterized protein. (147 aa)
	M3Y4E6_MUSPF	Uncharacterized protein. (160 aa)
	HOXA5	Homeobox A5. (270 aa)
	NFIB	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
	SAV1	Salvador family WW domain containing protein 1. (384 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	GATA6	GATA binding protein 6. (482 aa)
	SPDEF	SAM pointed domain containing ETS transcription factor. (335 aa)
	RCN3	Reticulocalbin 3. (389 aa)
	RBBP9	RB binding protein 9, serine hydrolase. (243 aa)
	NKX2-2	NK2 homeobox 2. (273 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	STRA6	Stimulated by retinoic acid 6. (684 aa)
	FNDC3B	Fibronectin type III domain containing 3B. (1206 aa)
	AIMP2	Aminoacyl tRNA synthetase complex interacting multifunctional protein 2. (320 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGR2	FOXA1	ENSMPUP00000013875	ENSMPUP00000016151	Anterior gradient 2, protein disulphide isomerase family member.	Forkhead box A1.	0.403
AGR2	SPDEF	ENSMPUP00000013875	ENSMPUP00000003134	Anterior gradient 2, protein disulphide isomerase family member.	SAM pointed domain containing ETS transcription factor.	0.570
BMP4	FGF10	ENSMPUP00000005423	ENSMPUP00000014301	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.818
BMP4	GATA6	ENSMPUP00000005423	ENSMPUP00000005576	Bone morphogenetic protein 4.	GATA binding protein 6.	0.600
BMP4	SOX9	ENSMPUP00000005423	ENSMPUP00000014195	Bone morphogenetic protein 4.	SRY-box transcription factor 9.	0.589
FGF10	BMP4	ENSMPUP00000014301	ENSMPUP00000005423	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.818
FGF10	FOXJ1	ENSMPUP00000014301	ENSMPUP00000013419	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Forkhead box J1.	0.477
FGF10	KRAS	ENSMPUP00000014301	ENSMPUP00000010217	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	KRAS proto-oncogene, GTPase.	0.634
FGF10	NKX2-1	ENSMPUP00000014301	ENSMPUP00000016159	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	NK2 homeobox 1.	0.509
FGF10	SOX9	ENSMPUP00000014301	ENSMPUP00000014195	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	SRY-box transcription factor 9.	0.532
FOXA1	AGR2	ENSMPUP00000016151	ENSMPUP00000013875	Forkhead box A1.	Anterior gradient 2, protein disulphide isomerase family member.	0.403
FOXA1	GATA6	ENSMPUP00000016151	ENSMPUP00000005576	Forkhead box A1.	GATA binding protein 6.	0.816
FOXA1	NKX2-1	ENSMPUP00000016151	ENSMPUP00000016159	Forkhead box A1.	NK2 homeobox 1.	0.596
FOXA1	NKX2-2	ENSMPUP00000016151	ENSMPUP00000001184	Forkhead box A1.	NK2 homeobox 2.	0.427
FOXJ1	FGF10	ENSMPUP00000013419	ENSMPUP00000014301	Forkhead box J1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.477
FOXJ1	NKX2-1	ENSMPUP00000013419	ENSMPUP00000016159	Forkhead box J1.	NK2 homeobox 1.	0.443
FOXJ1	SOX9	ENSMPUP00000013419	ENSMPUP00000014195	Forkhead box J1.	SRY-box transcription factor 9.	0.683
FOXJ1	SPDEF	ENSMPUP00000013419	ENSMPUP00000003134	Forkhead box J1.	SAM pointed domain containing ETS transcription factor.	0.497
GATA6	BMP4	ENSMPUP00000005576	ENSMPUP00000005423	GATA binding protein 6.	Bone morphogenetic protein 4.	0.600
GATA6	FOXA1	ENSMPUP00000005576	ENSMPUP00000016151	GATA binding protein 6.	Forkhead box A1.	0.816