(11 nodes) Morphogenesis of an epithelial fold network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (824 aa)
	RDH10	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
	GDF7	Growth differentiation factor 7. (382 aa)
	HOXD13	Homeobox D13. (341 aa)
	SOSTDC1	Sclerostin domain containing 1. (209 aa)
	CECR2	CECR2 histone acetyl-lysine reader. (1368 aa)
	LUZP1	Leucine zipper protein 1. (1073 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (586 aa)
	NODAL	Nodal growth differentiation factor. (348 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	FGF10	ENSMPUP00000005423	ENSMPUP00000014301	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.818
BMP4	NODAL	ENSMPUP00000005423	ENSMPUP00000004259	Bone morphogenetic protein 4.	Nodal growth differentiation factor.	0.405
FGF10	BMP4	ENSMPUP00000014301	ENSMPUP00000005423	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.818
FGF10	HIF1A	ENSMPUP00000014301	ENSMPUP00000006460	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hypoxia inducible factor 1 subunit alpha.	0.417
HIF1A	FGF10	ENSMPUP00000006460	ENSMPUP00000014301	Hypoxia inducible factor 1 subunit alpha.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.417
NODAL	BMP4	ENSMPUP00000004259	ENSMPUP00000005423	Nodal growth differentiation factor.	Bone morphogenetic protein 4.	0.405