(37 nodes) Ureteric bud morphogenesis network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TCF21	Transcription factor 21. (179 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (340 aa)
	SOX9	SRY-box transcription factor 9. (522 aa)
	GREB1	Uncharacterized protein. (1955 aa)
	GPC3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
	WT1	WT1 transcription factor. (433 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
	PAX8	Paired box 8. (462 aa)
	NPNT	Nephronectin. (597 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	DLG2	Uncharacterized protein. (833 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	ADAMTS16	ADAM metallopeptidase with thrombospondin type 1 motif 16. (1169 aa)
	PTCH1	Patched 1. (1386 aa)
	BMP2	Bone morphogenetic protein 2. (395 aa)
	GREB1L	GREB1 like retinoic acid receptor coactivator. (1971 aa)
	ILK	Integrin linked kinase. (452 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	M3Y0D8_MUSPF	Uncharacterized protein. (356 aa)
	HOXA11	Homeobox A11. (269 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa)
	HES1	Hes family bHLH transcription factor 1. (283 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (915 aa)
	GZF1	GDNF inducible zinc finger protein 1. (806 aa)
	WNT6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	GATA3	GATA binding protein 3. (444 aa)
	KIF26B	Kinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1878 aa)
	TMEM59L	Transmembrane protein 59 like. (351 aa)
	LHX1	LIM homeobox 1. (406 aa)
	TACSTD2	Tumor associated calcium signal transducer 2. (316 aa)
	GREM1	Gremlin. (184 aa)
	GLI3	GLI family zinc finger 3. (1585 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	LZTS2	Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (670 aa)
	GDNF	Glial cell derived neurotrophic factor. (211 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP2	BMP4	ENSMPUP00000006323	ENSMPUP00000005423	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.935
BMP2	FGF1	ENSMPUP00000006323	ENSMPUP00000007888	Bone morphogenetic protein 2.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.458
BMP2	FGF2	ENSMPUP00000006323	ENSMPUP00000017277	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.728
BMP2	GREM1	ENSMPUP00000006323	ENSMPUP00000019709	Bone morphogenetic protein 2.	Gremlin.	0.916
BMP2	SMAD4	ENSMPUP00000006323	ENSMPUP00000008705	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.836
BMP2	SOX9	ENSMPUP00000006323	ENSMPUP00000014195	Bone morphogenetic protein 2.	SRY-box transcription factor 9.	0.573
BMP4	BMP2	ENSMPUP00000005423	ENSMPUP00000006323	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.935
BMP4	FGF1	ENSMPUP00000005423	ENSMPUP00000007888	Bone morphogenetic protein 4.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.414
BMP4	FGF2	ENSMPUP00000005423	ENSMPUP00000017277	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.782
BMP4	GDNF	ENSMPUP00000005423	ENSMPUP00000014777	Bone morphogenetic protein 4.	Glial cell derived neurotrophic factor.	0.445
BMP4	GREM1	ENSMPUP00000005423	ENSMPUP00000019709	Bone morphogenetic protein 4.	Gremlin.	0.894
BMP4	PTCH1	ENSMPUP00000005423	ENSMPUP00000006660	Bone morphogenetic protein 4.	Patched 1.	0.537
BMP4	SMAD4	ENSMPUP00000005423	ENSMPUP00000008705	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.892
BMP4	SOX9	ENSMPUP00000005423	ENSMPUP00000014195	Bone morphogenetic protein 4.	SRY-box transcription factor 9.	0.589
BMP4	WNT1	ENSMPUP00000005423	ENSMPUP00000014615	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.452
BMP4	WNT11	ENSMPUP00000005423	ENSMPUP00000008719	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.418
DLG1	DLG2	ENSMPUP00000003739	ENSMPUP00000008068	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	Uncharacterized protein.	0.816
DLG2	DLG1	ENSMPUP00000008068	ENSMPUP00000003739	Uncharacterized protein.	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	0.816
EYA1	GATA3	ENSMPUP00000010517	ENSMPUP00000016298	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	GATA binding protein 3.	0.412
EYA1	GDNF	ENSMPUP00000010517	ENSMPUP00000014777	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Glial cell derived neurotrophic factor.	0.712