STRINGSTRING
RIPK1 RIPK1 IFIH1 IFIH1 EDN1 EDN1 TLR4 TLR4 CXCR4 CXCR4 IRF3 IRF3 CSF1 CSF1 C1QTNF4 C1QTNF4 GFI1 GFI1 DDX58 DDX58 M3XZQ7_MUSPF M3XZQ7_MUSPF M3XZR5_MUSPF M3XZR5_MUSPF FADD FADD PARP9 PARP9 M3Y193_MUSPF M3Y193_MUSPF TXK TXK HPX HPX UBE2K UBE2K HIF1A HIF1A M3Y5L5_MUSPF M3Y5L5_MUSPF LSM14A LSM14A NLRP6 NLRP6 MAVS MAVS IRF7 IRF7 STING1 STING1 GAS6 GAS6 IL7 IL7 RIPK2 RIPK2 TRAF2 TRAF2 DHX9 DHX9 TRIM44 TRIM44 IKBKE IKBKE PAFAH1B1 PAFAH1B1 TREM2 TREM2 TREML1 TREML1 CD74 CD74 M3YRW9_MUSPF M3YRW9_MUSPF M3YU90_MUSPF M3YU90_MUSPF TBK1 TBK1 AXL AXL M3Z266_MUSPF M3Z266_MUSPF TRIM32 TRIM32 TRIM56 TRIM56
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RIPK1Receptor interacting serine/threonine kinase 1. (646 aa)
IFIH1Interferon induced with helicase C domain 1. (1027 aa)
EDN1Endothelin 1. (202 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
IRF3Interferon regulatory factor 3. (421 aa)
CSF1Colony stimulating factor 1. (517 aa)
C1QTNF4C1q and TNF related 4. (272 aa)
GFI1Growth factor independent 1 transcriptional repressor. (386 aa)
DDX58DExD/H-box helicase 58. (937 aa)
M3XZQ7_MUSPFUbiquitin-like domain-containing protein. (311 aa)
M3XZR5_MUSPFRBR-type E3 ubiquitin transferase. (115 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (216 aa)
PARP9Poly [ADP-ribose] polymerase. (995 aa)
M3Y193_MUSPFC2 domain-containing protein. (500 aa)
TXKTyrosine-protein kinase. (551 aa)
HPXHemopexin. (463 aa)
UBE2KUbiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (269 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (824 aa)
M3Y5L5_MUSPFUncharacterized protein. (444 aa)
LSM14ALSM14A mRNA processing body assembly factor. (463 aa)
NLRP6NLR family pyrin domain containing 6. (948 aa)
MAVSMitochondrial antiviral signaling protein. (524 aa)
IRF7Interferon regulatory factor 7. (473 aa)
STING1Transmembrane protein 173. (378 aa)
GAS6Growth arrest specific 6. (541 aa)
IL7Interleukin 7. (158 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
DHX9DExH-box helicase 9. (1200 aa)
TRIM44Tripartite motif-containing 44. (344 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (719 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
TREML1Triggering receptor expressed on myeloid cells like 1. (314 aa)
CD74CD74 molecule. (279 aa)
M3YRW9_MUSPFIGv domain-containing protein. (315 aa)
M3YU90_MUSPFMediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (616 aa)
TBK1TANK-binding kinase 1. (729 aa)
AXLAXL receptor tyrosine kinase. (887 aa)
M3Z266_MUSPFC2 domain-containing protein. (537 aa)
TRIM32Tripartite motif containing 32. (673 aa)
TRIM56Tripartite motif containing 56. (771 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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