(16 nodes) Cell fate commitment involved in formation of primary germ layer network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RTF1	RTF1 homolog, Paf1/RNA polymerase II complex component. (710 aa)
	NODAL	Nodal growth differentiation factor. (348 aa)
	HOXA11	Homeobox A11. (269 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	SFRP2	Secreted frizzled related protein 2. (294 aa)
	GATA6	GATA binding protein 6. (482 aa)
	ETV2	ETS variant 2. (344 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	LEO1	LEO1 homolog, Paf1/RNA polymerase II complex component. (664 aa)
	SOX17	SRY-box transcription factor 17. (406 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
	EOMES	Eomesodermin. (669 aa)
	TBX6	T-box transcription factor 6. (436 aa)
	CTR9	CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
	NANOG	Homeobox domain-containing protein. (310 aa)
	PAF1	PAF1 homolog, Paf1/RNA polymerase II complex component. (554 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	EOMES	ENSMPUP00000005423	ENSMPUP00000011889	Bone morphogenetic protein 4.	Eomesodermin.	0.519
BMP4	GATA6	ENSMPUP00000005423	ENSMPUP00000005576	Bone morphogenetic protein 4.	GATA binding protein 6.	0.600
BMP4	NANOG	ENSMPUP00000005423	ENSMPUP00000016627	Bone morphogenetic protein 4.	Homeobox domain-containing protein.	0.806
BMP4	NODAL	ENSMPUP00000005423	ENSMPUP00000004259	Bone morphogenetic protein 4.	Nodal growth differentiation factor.	0.405
BMP4	SMAD1	ENSMPUP00000005423	ENSMPUP00000006812	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.675
BMP4	SOX17	ENSMPUP00000005423	ENSMPUP00000010429	Bone morphogenetic protein 4.	SRY-box transcription factor 17.	0.800
BMP4	TBX6	ENSMPUP00000005423	ENSMPUP00000012492	Bone morphogenetic protein 4.	T-box transcription factor 6.	0.536
CTR9	LEO1	ENSMPUP00000012777	ENSMPUP00000007593	CTR9 homolog, Paf1/RNA polymerase II complex component.	LEO1 homolog, Paf1/RNA polymerase II complex component.	0.999
CTR9	PAF1	ENSMPUP00000012777	ENSMPUP00000017617	CTR9 homolog, Paf1/RNA polymerase II complex component.	PAF1 homolog, Paf1/RNA polymerase II complex component.	0.998
CTR9	RTF1	ENSMPUP00000012777	ENSMPUP00000008835	CTR9 homolog, Paf1/RNA polymerase II complex component.	RTF1 homolog, Paf1/RNA polymerase II complex component.	0.999
EOMES	BMP4	ENSMPUP00000011889	ENSMPUP00000005423	Eomesodermin.	Bone morphogenetic protein 4.	0.519
EOMES	GATA6	ENSMPUP00000011889	ENSMPUP00000005576	Eomesodermin.	GATA binding protein 6.	0.583
EOMES	NANOG	ENSMPUP00000011889	ENSMPUP00000016627	Eomesodermin.	Homeobox domain-containing protein.	0.596
EOMES	NODAL	ENSMPUP00000011889	ENSMPUP00000004259	Eomesodermin.	Nodal growth differentiation factor.	0.627
EOMES	SOX17	ENSMPUP00000011889	ENSMPUP00000010429	Eomesodermin.	SRY-box transcription factor 17.	0.792
GATA6	BMP4	ENSMPUP00000005576	ENSMPUP00000005423	GATA binding protein 6.	Bone morphogenetic protein 4.	0.600
GATA6	EOMES	ENSMPUP00000005576	ENSMPUP00000011889	GATA binding protein 6.	Eomesodermin.	0.583
GATA6	NANOG	ENSMPUP00000005576	ENSMPUP00000016627	GATA binding protein 6.	Homeobox domain-containing protein.	0.835
GATA6	NODAL	ENSMPUP00000005576	ENSMPUP00000004259	GATA binding protein 6.	Nodal growth differentiation factor.	0.524
GATA6	SOX17	ENSMPUP00000005576	ENSMPUP00000010429	GATA binding protein 6.	SRY-box transcription factor 17.	0.889