STRINGSTRING
IL6 IL6 ZC3H10 ZC3H10 EGFR EGFR ZFP36 ZFP36 TGFB1 TGFB1 MAEL MAEL PUM1 PUM1 LIMD1 LIMD1 ZC3H12A ZC3H12A M3YT25_MUSPF M3YT25_MUSPF BCDIN3D BCDIN3D ZMPSTE24 ZMPSTE24 PUM2 PUM2 TRIM71 TRIM71 DHX9 DHX9 FMR1 FMR1 TNF TNF STAT3 STAT3 ESR1 ESR1 NCOR1 NCOR1 LIN28B LIN28B PPP3CA PPP3CA M3YCX9_MUSPF M3YCX9_MUSPF TP53 TP53 ELAVL1 ELAVL1 M3Y7U3_MUSPF M3Y7U3_MUSPF AJUBA AJUBA BMP4 BMP4 TRUB1 TRUB1 M3XVG1_MUSPF M3XVG1_MUSPF TIAL1 TIAL1 FXR1 FXR1 NCOR2 NCOR2 RIPK1 RIPK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
ZC3H10Zinc finger CCCH-type containing 10. (435 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
ZFP36ZFP36 ring finger protein. (327 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
MAELMaelstrom spermatogenic transposon silencer. (434 aa)
PUM1Pumilio RNA binding family member 1. (1188 aa)
LIMD1LIM domains containing 1. (671 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (576 aa)
M3YT25_MUSPFUncharacterized protein; Belongs to the DEAD box helicase family. (372 aa)
BCDIN3DBCDIN3 domain containing RNA methyltransferase. (273 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
PUM2Pumilio RNA binding family member 2. (1063 aa)
TRIM71Tripartite motif containing 71. (514 aa)
DHX9DExH-box helicase 9. (1200 aa)
FMR1Fragile X mental retardation 1. (615 aa)
TNFTumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (597 aa)
NCOR1Nuclear receptor corepressor 1. (2510 aa)
LIN28BLin-28 homolog B. (250 aa)
PPP3CASerine/threonine-protein phosphatase. (461 aa)
M3YCX9_MUSPFUncharacterized protein; Belongs to the DEAD box helicase family. (671 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (326 aa)
M3Y7U3_MUSPFUncharacterized protein. (240 aa)
AJUBAAjuba LIM protein. (548 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
TRUB1TruB pseudouridine synthase family member 1. (350 aa)
M3XVG1_MUSPFHelicase C-terminal domain-containing protein. (106 aa)
TIAL1TIA1 cytotoxic granule associated RNA binding protein like 1. (375 aa)
FXR1FMR1 autosomal homolog 1. (648 aa)
NCOR2Nuclear receptor corepressor 2. (2525 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (646 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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