(74 nodes) Negative regulation of small molecule metabolic process network (Mustela putorius)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	FLCN	UDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
	ERFE	Erythroferrone. (402 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1083 aa)
	ETFBKMT	Electron transfer flavoprotein subunit beta lysine methyltransferase. (266 aa)
	LEPR	Leptin receptor. (1164 aa)
	INSIG2	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
	CYP27B1	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (515 aa)
	ACMSD	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (270 aa)
	DKKL1	Dickkopf like acrosomal protein 1. (233 aa)
	BMP5	Bone morphogenetic protein 5. (454 aa)
	SIRT4	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
	ACTN3	Actinin alpha 3 (gene/pseudogene). (904 aa)
	SERPINA12	Serpin family A member 12; Belongs to the serpin family. (414 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (244 aa)
	DDIT4	DNA damage inducible transcript 4. (230 aa)
	GFI1	Growth factor independent 1 transcriptional repressor. (386 aa)
	PID1	Phosphotyrosine interaction domain containing 1. (217 aa)
	ATCAY	ATCAY kinesin light chain interacting caytaxin. (371 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
	REST	RE1 silencing transcription factor. (1098 aa)
	SIRT6	Sirtuin 6. (359 aa)
	PLIN5	Perilipin; Belongs to the perilipin family. (480 aa)
	PDZD3	PDZ domain containing 3. (505 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (109 aa)
	BMP2	Bone morphogenetic protein 2. (395 aa)
	FBP1	Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
	FAM3C	Family with sequence similarity 3 member C. (227 aa)
	CBFA2T3	CBFA2/RUNX1 partner transcriptional co-repressor 3. (630 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
	TIGAR	TP53 induced glycolysis regulatory phosphatase. (270 aa)
	SLC4A1	Anion exchange protein. (924 aa)
	INSIG1	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (113 aa)
	M3YE86_MUSPF	Uncharacterized protein. (766 aa)
	M3YEG5_MUSPF	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (766 aa)
	ERLIN2	ER lipid raft associated 2. (337 aa)
	NCOR1	Nuclear receptor corepressor 1. (2510 aa)
	PIBF1	Progesterone immunomodulatory binding factor 1. (757 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	ACADVL	Acyl-CoA dehydrogenase very long chain. (579 aa)
	SNAI2	Snail family transcriptional repressor 2. (268 aa)
	ATP2B4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1206 aa)
	IER3	Immediate early response 3. (155 aa)
	M3YKG1_MUSPF	Uncharacterized protein. (352 aa)
	M3YKG8_MUSPF	MAM domain-containing protein. (110 aa)
	MALRD1	MAM and LDL receptor class A domain containing 1. (1452 aa)
	SIRT1	Sirtuin 1. (557 aa)
	CYP27C1	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (416 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (660 aa)
	CRY1	Cryptochrome circadian regulator 1. (587 aa)
	DKK3	Dickkopf WNT signaling pathway inhibitor 3. (348 aa)
	SLC27A4	Solute carrier family 27 member 4. (651 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	MST1	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (711 aa)
	PRMT3	Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (531 aa)
	GIT1	GIT ArfGAP 1. (708 aa)
	C1QTNF12	C1q and TNF related 12. (305 aa)
	MFSD2A	Major facilitator superfamily domain containing 2A. (529 aa)
	SOX9	SRY-box transcription factor 9. (522 aa)
	M3YUN0_MUSPF	C1q domain-containing protein. (306 aa)
	FMO3	Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
	LOC101681442	Dimethylaniline monooxygenase [N-oxide-forming]. (534 aa)
	FMO2	Dimethylaniline monooxygenase [N-oxide-forming]. (539 aa)
	FMO1	Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
	FMO4	Dimethylaniline monooxygenase [N-oxide-forming]. (556 aa)
	WDTC1	WD and tetratricopeptide repeats 1. (679 aa)
	RD3	Retinal degeneration 3, GUCY2D regulator. (197 aa)
	FIS1	Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
	TSPO	Translocator protein. (169 aa)
	EP300	E1A binding protein p300. (2425 aa)
	ERLIN1	ER lipid raft associated 1. (310 aa)
	SNAI1	Snail family transcriptional repressor 1. (264 aa)
	TRIB3	Tribbles pseudokinase 3. (358 aa)
	GCK	Phosphotransferase. (473 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	APPL2	ENSMPUP00000003314	ENSMPUP00000012020	Adiponectin, C1Q and collagen domain containing.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.506
ADIPOQ	INS	ENSMPUP00000003314	ENSMPUP00000005593	Adiponectin, C1Q and collagen domain containing.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.771
ADIPOQ	LEPR	ENSMPUP00000003314	ENSMPUP00000000731	Adiponectin, C1Q and collagen domain containing.	Leptin receptor.	0.526
ADIPOQ	PLIN5	ENSMPUP00000003314	ENSMPUP00000005061	Adiponectin, C1Q and collagen domain containing.	Perilipin; Belongs to the perilipin family.	0.635
ADIPOQ	SIRT1	ENSMPUP00000003314	ENSMPUP00000011868	Adiponectin, C1Q and collagen domain containing.	Sirtuin 1.	0.511
APPL2	ADIPOQ	ENSMPUP00000012020	ENSMPUP00000003314	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Adiponectin, C1Q and collagen domain containing.	0.506
APPL2	ATCAY	ENSMPUP00000012020	ENSMPUP00000004419	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	ATCAY kinesin light chain interacting caytaxin.	0.402
ATCAY	APPL2	ENSMPUP00000004419	ENSMPUP00000012020	ATCAY kinesin light chain interacting caytaxin.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.402
ATCAY	EP300	ENSMPUP00000004419	ENSMPUP00000016323	ATCAY kinesin light chain interacting caytaxin.	E1A binding protein p300.	0.430
BMP2	BMP5	ENSMPUP00000006323	ENSMPUP00000002775	Bone morphogenetic protein 2.	Bone morphogenetic protein 5.	0.527
BMP2	FGF19	ENSMPUP00000006323	ENSMPUP00000004571	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.518
BMP2	INS	ENSMPUP00000006323	ENSMPUP00000005593	Bone morphogenetic protein 2.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.518
BMP2	SOX9	ENSMPUP00000006323	ENSMPUP00000014195	Bone morphogenetic protein 2.	SRY-box transcription factor 9.	0.573
BMP5	BMP2	ENSMPUP00000002775	ENSMPUP00000006323	Bone morphogenetic protein 5.	Bone morphogenetic protein 2.	0.527
CBFA2T3	NCOR1	ENSMPUP00000007559	ENSMPUP00000010116	CBFA2/RUNX1 partner transcriptional co-repressor 3.	Nuclear receptor corepressor 1.	0.527
CRY1	TSPO	ENSMPUP00000012065	ENSMPUP00000016193	Cryptochrome circadian regulator 1.	Translocator protein.	0.473
DDIT4	EP300	ENSMPUP00000004046	ENSMPUP00000016323	DNA damage inducible transcript 4.	E1A binding protein p300.	0.743
DDIT4	TP53	ENSMPUP00000004046	ENSMPUP00000008945	DNA damage inducible transcript 4.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.467
DDIT4	TRIB3	ENSMPUP00000004046	ENSMPUP00000017813	DNA damage inducible transcript 4.	Tribbles pseudokinase 3.	0.514
EP300	ATCAY	ENSMPUP00000016323	ENSMPUP00000004419	E1A binding protein p300.	ATCAY kinesin light chain interacting caytaxin.	0.430