(17 nodes) Necroptotic process network (Mustela putorius)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Your Input:
	FASLG	Fas ligand; Belongs to the tumor necrosis factor family. (275 aa)
	TNF	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (764 aa)
	IPMK	Kinase; Belongs to the inositol phosphokinase (IPK) family. (430 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
	NLRP6	NLR family pyrin domain containing 6. (948 aa)
	TRPM7	Transient receptor potential cation channel subfamily M member 7. (1738 aa)
	FAS	Fas cell surface death receptor. (311 aa)
	PYGL	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (858 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (216 aa)
	PPIF	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (211 aa)
	ITPK1	Inositol-tetrakisphosphate 1-kinase. (461 aa)
	CYLD	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (953 aa)
	PGAM5	PGAM family member 5, mitochondrial serine/threonine protein phosphatase. (226 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (646 aa)
	DNM1L	Dynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
	SPATA2	Spermatogenesis associated 2. (446 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYLD	FADD	ENSMPUP00000003166	ENSMPUP00000004665	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.832
CYLD	RIPK1	ENSMPUP00000003166	ENSMPUP00000000449	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	Receptor interacting serine/threonine kinase 1.	0.987
CYLD	TNF	ENSMPUP00000003166	ENSMPUP00000011297	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	0.861
DNM1L	PGAM5	ENSMPUP00000000219	ENSMPUP00000002611	Dynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	PGAM family member 5, mitochondrial serine/threonine protein phosphatase.	0.958
DNM1L	RIPK1	ENSMPUP00000000219	ENSMPUP00000000449	Dynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Receptor interacting serine/threonine kinase 1.	0.942
FADD	CYLD	ENSMPUP00000004665	ENSMPUP00000003166	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	0.832
FADD	FAS	ENSMPUP00000004665	ENSMPUP00000006453	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Fas cell surface death receptor.	0.998
FADD	FASLG	ENSMPUP00000004665	ENSMPUP00000015535	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Fas ligand; Belongs to the tumor necrosis factor family.	0.953
FADD	RIPK1	ENSMPUP00000004665	ENSMPUP00000000449	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Receptor interacting serine/threonine kinase 1.	0.998
FADD	TLR3	ENSMPUP00000004665	ENSMPUP00000011144	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.523
FADD	TNF	ENSMPUP00000004665	ENSMPUP00000011297	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	0.799
FADD	TP53	ENSMPUP00000004665	ENSMPUP00000008945	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.662
FAS	FADD	ENSMPUP00000006453	ENSMPUP00000004665	Fas cell surface death receptor.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.998
FAS	FASLG	ENSMPUP00000006453	ENSMPUP00000015535	Fas cell surface death receptor.	Fas ligand; Belongs to the tumor necrosis factor family.	0.994
FAS	RIPK1	ENSMPUP00000006453	ENSMPUP00000000449	Fas cell surface death receptor.	Receptor interacting serine/threonine kinase 1.	0.830
FAS	TNF	ENSMPUP00000006453	ENSMPUP00000011297	Fas cell surface death receptor.	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	0.668
FASLG	FADD	ENSMPUP00000015535	ENSMPUP00000004665	Fas ligand; Belongs to the tumor necrosis factor family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.953
FASLG	FAS	ENSMPUP00000015535	ENSMPUP00000006453	Fas ligand; Belongs to the tumor necrosis factor family.	Fas cell surface death receptor.	0.994
FASLG	RIPK1	ENSMPUP00000015535	ENSMPUP00000000449	Fas ligand; Belongs to the tumor necrosis factor family.	Receptor interacting serine/threonine kinase 1.	0.712
FASLG	TNF	ENSMPUP00000015535	ENSMPUP00000011297	Fas ligand; Belongs to the tumor necrosis factor family.	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	0.452