(40 nodes) Cellular response to hydrogen peroxide network (Mustela putorius)

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second shell of interactors

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	PARK7	Parkinsonism associated deglycase. (189 aa)
	SRC	Tyrosine-protein kinase. (536 aa)
	OSER1	Oxidative stress responsive serine rich 1. (292 aa)
	AXL	AXL receptor tyrosine kinase. (887 aa)
	ECT2	Epithelial cell transforming 2. (914 aa)
	PDCD10	Programmed cell death 10. (212 aa)
	ANKZF1	Ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1. (720 aa)
	NET1	Neuroepithelial cell transforming 1. (542 aa)
	PCGF2	Polycomb group RING finger protein 2. (344 aa)
	TNFAIP3	TNF alpha induced protein 3. (790 aa)
	MAP3K5	Mitogen-activated protein kinase kinase kinase 5. (1398 aa)
	M3YRV1_MUSPF	Uncharacterized protein. (286 aa)
	HDAC6	Histone deacetylase 6. (1199 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
	SPHK1	Sphingosine kinase 1. (386 aa)
	ABL1	Tyrosine-protein kinase. (1150 aa)
	MAPK7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
	SETX	Senataxin. (2682 aa)
	SIRT1	Sirtuin 1. (557 aa)
	CAT	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (511 aa)
	TRPA1	Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1117 aa)
	CYP1B1	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (544 aa)
	TRPM2	Transient receptor potential cation channel subfamily M member 2. (1496 aa)
	FXN	Frataxin. (155 aa)
	RNF112	Ring finger protein 112. (605 aa)
	STK25	Serine/threonine kinase 25. (426 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (646 aa)
	EDN1	Endothelin 1. (202 aa)
	RPS3	Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
	KDM6B	Lysine demethylase 6B. (1668 aa)
	ANXA1	Annexin. (345 aa)
	ZNF277	Zinc finger protein 277. (456 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (753 aa)
	PPIF	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (211 aa)
	MAPK13	Mitogen-activated protein kinase. (366 aa)
	SIGMAR1	Sigma non-opioid intracellular receptor 1. (223 aa)
	AQP1	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
	IMPACT	Impact RWD domain protein. (318 aa)
	SMPD3	Sphingomyelin phosphodiesterase 3. (658 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	MAPK13	ENSMPUP00000012584	ENSMPUP00000004034	Tyrosine-protein kinase.	Mitogen-activated protein kinase.	0.415
ANXA1	IL6	ENSMPUP00000008827	ENSMPUP00000013489	Annexin.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.465
AXL	SRC	ENSMPUP00000017543	ENSMPUP00000017650	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.863
CAT	PARK7	ENSMPUP00000011568	ENSMPUP00000006528	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Parkinsonism associated deglycase.	0.856
EDN1	IL6	ENSMPUP00000000674	ENSMPUP00000013489	Endothelin 1.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.526
EDN1	SRC	ENSMPUP00000000674	ENSMPUP00000017650	Endothelin 1.	Tyrosine-protein kinase.	0.463
EZH2	IL6	ENSMPUP00000007191	ENSMPUP00000013489	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.482
EZH2	KDM6B	ENSMPUP00000007191	ENSMPUP00000008836	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	Lysine demethylase 6B.	0.836
EZH2	PCGF2	ENSMPUP00000007191	ENSMPUP00000014973	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	Polycomb group RING finger protein 2.	0.722
EZH2	RELA	ENSMPUP00000007191	ENSMPUP00000011545	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	RELA proto-oncogene, NF-kB subunit.	0.409
EZH2	SIRT1	ENSMPUP00000007191	ENSMPUP00000011868	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	Sirtuin 1.	0.701
HDAC6	PARK7	ENSMPUP00000013557	ENSMPUP00000006528	Histone deacetylase 6.	Parkinsonism associated deglycase.	0.591
HDAC6	SIRT1	ENSMPUP00000013557	ENSMPUP00000011868	Histone deacetylase 6.	Sirtuin 1.	0.627
IL6	ANXA1	ENSMPUP00000013489	ENSMPUP00000008827	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Annexin.	0.465
IL6	EDN1	ENSMPUP00000013489	ENSMPUP00000000674	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Endothelin 1.	0.526
IL6	EZH2	ENSMPUP00000013489	ENSMPUP00000007191	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.482
IL6	M3YRV1_MUSPF	ENSMPUP00000013489	ENSMPUP00000014061	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Uncharacterized protein.	0.680
IL6	RELA	ENSMPUP00000013489	ENSMPUP00000011545	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	RELA proto-oncogene, NF-kB subunit.	0.972
IL6	SIRT1	ENSMPUP00000013489	ENSMPUP00000011868	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Sirtuin 1.	0.577
IL6	SRC	ENSMPUP00000013489	ENSMPUP00000017650	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Tyrosine-protein kinase.	0.645