(40 nodes) ERK1 and ERK2 cascade network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	WNK4	WNK lysine deficient protein kinase 4. (1242 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
	MAPK1	Mitogen-activated protein kinase. (333 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1013 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (715 aa)
	ITGAV	Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
	TBC1D10C	TBC1 domain family member 10C. (446 aa)
	IQGAP3	IQ motif containing GTPase activating protein 3. (1610 aa)
	HTR2B	5-hydroxytryptamine receptor 2B. (481 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (952 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1355 aa)
	ZFP36L1	ZFP36 ring finger protein like 1. (317 aa)
	SPRY1	Sprouty-like protein 1, antagonist of FGF signaling. (319 aa)
	LOC101676600	Homeobox domain-containing protein. (185 aa)
	SPRY2	Sprouty RTK signaling antagonist 2. (315 aa)
	M3Z3T6_MUSPF	Homeobox domain-containing protein. (184 aa)
	GRB10	Growth factor receptor bound protein 10. (611 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	M3YZI9_MUSPF	Homeobox domain-containing protein. (197 aa)
	M3YY40_MUSPF	DUF3496 domain-containing protein. (376 aa)
	CTSH	Cathepsin H; Belongs to the peptidase C1 family. (335 aa)
	C1QL4	Complement C1q like 4. (259 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	AVP	Arginine vasopressin; Belongs to the vasopressin/oxytocin family. (170 aa)
	OXT	Oxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
	KARS1	Lysine--tRNA ligase. (625 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
	ZFP36L2	ZFP36 ring finger protein like 2. (495 aa)
	IGF1	Insulin like growth factor 1. (153 aa)
	RAPGEF1	Rap guanine nucleotide exchange factor 1. (1265 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
	ABL1	Tyrosine-protein kinase. (1150 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	LOC101677498	DUF3496 domain-containing protein. (265 aa)
	SOX9	SRY-box transcription factor 9. (522 aa)
	FLCN	UDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
	EDN1	Endothelin 1. (202 aa)
	M3XP97_MUSPF	ANK_REP_REGION domain-containing protein. (132 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	MAPK1	ENSMPUP00000012584	ENSMPUP00000003112	Tyrosine-protein kinase.	Mitogen-activated protein kinase.	0.409
ABL1	MAPK3	ENSMPUP00000012584	ENSMPUP00000012543	Tyrosine-protein kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.409
AVP	EDN1	ENSMPUP00000008872	ENSMPUP00000000674	Arginine vasopressin; Belongs to the vasopressin/oxytocin family.	Endothelin 1.	0.493
BRAF	IQGAP3	ENSMPUP00000003381	ENSMPUP00000004182	B-Raf proto-oncogene, serine/threonine kinase.	IQ motif containing GTPase activating protein 3.	0.511
BRAF	MAPK1	ENSMPUP00000003381	ENSMPUP00000003112	B-Raf proto-oncogene, serine/threonine kinase.	Mitogen-activated protein kinase.	0.868
BRAF	MAPK3	ENSMPUP00000003381	ENSMPUP00000012543	B-Raf proto-oncogene, serine/threonine kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.856
BRAF	SPRY2	ENSMPUP00000003381	ENSMPUP00000018649	B-Raf proto-oncogene, serine/threonine kinase.	Sprouty RTK signaling antagonist 2.	0.939
EDN1	AVP	ENSMPUP00000000674	ENSMPUP00000008872	Endothelin 1.	Arginine vasopressin; Belongs to the vasopressin/oxytocin family.	0.493
EDN1	FGF2	ENSMPUP00000000674	ENSMPUP00000017277	Endothelin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.645
EDN1	KDR	ENSMPUP00000000674	ENSMPUP00000005134	Endothelin 1.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.529
FGF10	FGF18	ENSMPUP00000014301	ENSMPUP00000012757	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.472
FGF10	FGF2	ENSMPUP00000014301	ENSMPUP00000017277	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.477
FGF10	FGF23	ENSMPUP00000014301	ENSMPUP00000009243	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.644
FGF10	KDR	ENSMPUP00000014301	ENSMPUP00000005134	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.904
FGF10	SOX9	ENSMPUP00000014301	ENSMPUP00000014195	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	SRY-box transcription factor 9.	0.532
FGF18	FGF10	ENSMPUP00000012757	ENSMPUP00000014301	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.472
FGF18	FGF2	ENSMPUP00000012757	ENSMPUP00000017277	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.483
FGF18	FGF23	ENSMPUP00000012757	ENSMPUP00000009243	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.715
FGF18	KDR	ENSMPUP00000012757	ENSMPUP00000005134	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.899
FGF18	SOX9	ENSMPUP00000012757	ENSMPUP00000014195	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	SRY-box transcription factor 9.	0.476