(36 nodes) Multivesicular body sorting pathway network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LEPROT	Leptin receptor overlapping transcript. (131 aa)
	TMEM50B	Transmembrane protein 50B. (158 aa)
	CHMP4C	Charged multivesicular body protein 4C. (237 aa)
	RAB27A	RAB27A, member RAS oncogene family. (221 aa)
	SYTL4	Synaptotagmin like 4. (671 aa)
	LYST	Lysosomal trafficking regulator. (3799 aa)
	DENND10	DENN domain containing 10. (391 aa)
	SORT1	Sortilin. (694 aa)
	CHMP7	Charged multivesicular body protein 7. (398 aa)
	CHMP5	Charged multivesicular body protein 5. (219 aa)
	VCP	Valosin containing protein; Belongs to the AAA ATPase family. (806 aa)
	UBXN6	UBX domain protein 6. (442 aa)
	CHMP4A	Charged multivesicular body protein 4A. (266 aa)
	EXPH5	Exophilin 5. (1998 aa)
	VPS28	Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (221 aa)
	CHMP1A	Charged multivesicular body protein 1A. (196 aa)
	CHMP2A	Charged multivesicular body protein 2A. (222 aa)
	M3YBF1_MUSPF	Uncharacterized protein. (135 aa)
	M3YCZ1_MUSPF	Uncharacterized protein. (223 aa)
	VPS25	Vacuolar protein sorting 25 homolog. (176 aa)
	CHMP2B	Charged multivesicular body protein 2B. (213 aa)
	M3YIW8_MUSPF	Uncharacterized protein. (113 aa)
	STAM	Signal transducing adaptor molecule. (520 aa)
	CHMP6	Charged multivesicular body protein 6. (199 aa)
	M3YL30_MUSPF	Uncharacterized protein. (1274 aa)
	PDCD6IP	Programmed cell death 6 interacting protein. (869 aa)
	LAPTM4A	Lysosomal protein transmembrane 4 alpha. (233 aa)
	M3YUA0_MUSPF	BRO1 domain-containing protein. (656 aa)
	SNF8	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
	M3YWH6_MUSPF	Uncharacterized protein. (120 aa)
	MVB12A	Multivesicular body subunit 12A. (273 aa)
	RAB27B	RAB27B, member RAS oncogene family. (218 aa)
	VPS4B	Vacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (422 aa)
	CHMP4B	Charged multivesicular body protein 4B. (224 aa)
	VPS36	Vacuolar protein sorting 36 homolog. (238 aa)
	VTA1	Vesicle trafficking 1. (306 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHMP1A	CHMP2A	ENSMPUP00000007224	ENSMPUP00000008204	Charged multivesicular body protein 1A.	Charged multivesicular body protein 2A.	0.998
CHMP1A	CHMP2B	ENSMPUP00000007224	ENSMPUP00000010554	Charged multivesicular body protein 1A.	Charged multivesicular body protein 2B.	0.990
CHMP1A	CHMP4A	ENSMPUP00000007224	ENSMPUP00000005819	Charged multivesicular body protein 1A.	Charged multivesicular body protein 4A.	0.911
CHMP1A	CHMP4B	ENSMPUP00000007224	ENSMPUP00000017710	Charged multivesicular body protein 1A.	Charged multivesicular body protein 4B.	0.987
CHMP1A	CHMP4C	ENSMPUP00000007224	ENSMPUP00000001777	Charged multivesicular body protein 1A.	Charged multivesicular body protein 4C.	0.989
CHMP1A	CHMP5	ENSMPUP00000007224	ENSMPUP00000004092	Charged multivesicular body protein 1A.	Charged multivesicular body protein 5.	0.992
CHMP1A	CHMP6	ENSMPUP00000007224	ENSMPUP00000011799	Charged multivesicular body protein 1A.	Charged multivesicular body protein 6.	0.964
CHMP1A	CHMP7	ENSMPUP00000007224	ENSMPUP00000003440	Charged multivesicular body protein 1A.	Charged multivesicular body protein 7.	0.963
CHMP1A	M3YCZ1_MUSPF	ENSMPUP00000007224	ENSMPUP00000009198	Charged multivesicular body protein 1A.	Uncharacterized protein.	0.995
CHMP1A	MVB12A	ENSMPUP00000007224	ENSMPUP00000015780	Charged multivesicular body protein 1A.	Multivesicular body subunit 12A.	0.644
CHMP1A	PDCD6IP	ENSMPUP00000007224	ENSMPUP00000013136	Charged multivesicular body protein 1A.	Programmed cell death 6 interacting protein.	0.408
CHMP1A	SNF8	ENSMPUP00000007224	ENSMPUP00000015246	Charged multivesicular body protein 1A.	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family.	0.791
CHMP1A	STAM	ENSMPUP00000007224	ENSMPUP00000011543	Charged multivesicular body protein 1A.	Signal transducing adaptor molecule.	0.492
CHMP1A	VPS25	ENSMPUP00000007224	ENSMPUP00000010051	Charged multivesicular body protein 1A.	Vacuolar protein sorting 25 homolog.	0.706
CHMP1A	VPS28	ENSMPUP00000007224	ENSMPUP00000006203	Charged multivesicular body protein 1A.	Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.	0.724
CHMP1A	VPS36	ENSMPUP00000007224	ENSMPUP00000017884	Charged multivesicular body protein 1A.	Vacuolar protein sorting 36 homolog.	0.660
CHMP1A	VPS4B	ENSMPUP00000007224	ENSMPUP00000016422	Charged multivesicular body protein 1A.	Vacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family.	0.994
CHMP1A	VTA1	ENSMPUP00000007224	ENSMPUP00000017928	Charged multivesicular body protein 1A.	Vesicle trafficking 1.	0.998
CHMP2A	CHMP1A	ENSMPUP00000008204	ENSMPUP00000007224	Charged multivesicular body protein 2A.	Charged multivesicular body protein 1A.	0.998
CHMP2A	CHMP2B	ENSMPUP00000008204	ENSMPUP00000010554	Charged multivesicular body protein 2A.	Charged multivesicular body protein 2B.	0.984