STRINGSTRING
LRP2 LRP2 FZD3 FZD3 SHANK3 SHANK3 BRD2 BRD2 KDM2B KDM2B CC2D2A CC2D2A TCTN1 TCTN1 PLXNB2 PLXNB2 FUZ FUZ DVL3 DVL3 CELSR1 CELSR1 TEAD2 TEAD2 IRX3 IRX3 OPA1 OPA1 GLMN GLMN NODAL NODAL MED12 MED12 LMO4 LMO4 M3Y0D8_MUSPF M3Y0D8_MUSPF SOX4 SOX4 M3Y0V5_MUSPF M3Y0V5_MUSPF ARHGAP35 ARHGAP35 HECTD1 HECTD1 BCL10 BCL10 BMP4 BMP4 SFRP2 SFRP2 MIB1 MIB1 GREM1 GREM1 FZD2 FZD2 GDF7 GDF7 OSR1 OSR1 HAND1 HAND1 TRIM71 TRIM71 PTK7 PTK7 KDM6A KDM6A ABL1 ABL1 TSC1 TSC1 TRAF6 TRAF6 SEMA4C SEMA4C PRKACB PRKACB M3Y377_MUSPF M3Y377_MUSPF VASP VASP LIAS LIAS RARG RARG HIF1A HIF1A MTHFD1 MTHFD1 PTCH1 PTCH1 IRX1 IRX1 MTHFR MTHFR LUZP1 LUZP1 SOX8 SOX8 LHX2 LHX2 SOX9 SOX9 DVL1 DVL1 FGF10 FGF10 GDNF GDNF TCAP TCAP SETD2 SETD2 CLUAP1 CLUAP1 CTHRC1 CTHRC1 M3YUX6_MUSPF M3YUX6_MUSPF STK3 STK3 MKS1 MKS1 IRX2 IRX2 SCRIB SCRIB WNT9B WNT9B SHROOM3 SHROOM3 SEC24B SEC24B ST14 ST14 SPINT1 SPINT1 LRRC1 LRRC1 TULP3 TULP3 PAX8 PAX8 IFT57 IFT57 M3YFG7_MUSPF M3YFG7_MUSPF MTHFD1L MTHFD1L DVL2 DVL2 KAT2A KAT2A GRHL3 GRHL3 PHACTR4 PHACTR4 CITED2 CITED2 LOC101676600 LOC101676600 M3Z3T6_MUSPF M3Z3T6_MUSPF COBL COBL RALA RALA CECR2 CECR2 SPINT2 SPINT2 IFT52 IFT52 TGFB1 TGFB1 STK4 STK4 SALL4 SALL4 RET RET BBS4 BBS4 SUFU SUFU M3YZI9_MUSPF M3YZI9_MUSPF WNT6 WNT6 GATA3 GATA3 PRICKLE1 PRICKLE1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LRP2LDL receptor related protein 2. (4699 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1712 aa)
BRD2Bromodomain containing 2. (803 aa)
KDM2BLysine demethylase 2B. (1310 aa)
CC2D2ACoiled-coil and C2 domain containing 2A. (1621 aa)
TCTN1Tectonic family member 1. (589 aa)
PLXNB2Plexin B2. (1841 aa)
FUZFuzzy planar cell polarity protein. (392 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2735 aa)
TEAD2TEA domain transcription factor 2. (545 aa)
IRX3Iroquois homeobox 3. (502 aa)
OPA1OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1015 aa)
GLMNGlomulin, FKBP associated protein. (600 aa)
NODALNodal growth differentiation factor. (348 aa)
MED12Mediator complex subunit 12. (2168 aa)
LMO4LIM domain only 4. (165 aa)
M3Y0D8_MUSPFUncharacterized protein. (356 aa)
SOX4SRY-box transcription factor 4. (269 aa)
M3Y0V5_MUSPFPodocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (514 aa)
ARHGAP35Rho GTPase activating protein 35. (1500 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
BCL10BCL10 immune signaling adaptor. (241 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (1006 aa)
GREM1Gremlin. (184 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (550 aa)
GDF7Growth differentiation factor 7. (382 aa)
OSR1Odd-skipped related transcription factor 1. (267 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
TRIM71Tripartite motif containing 71. (514 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
KDM6ALysine demethylase 6A. (1419 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
TSC1TSC complex subunit 1. (1165 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (867 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
M3Y377_MUSPFNTR domain-containing protein. (233 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (382 aa)
LIASLipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (362 aa)
RARGRetinoic acid receptor gamma. (458 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (824 aa)
MTHFD1Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (935 aa)
PTCH1Patched 1. (1386 aa)
IRX1Iroquois homeobox 1. (319 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (654 aa)
LUZP1Leucine zipper protein 1. (1073 aa)
SOX8SRY-box transcription factor 8. (377 aa)
LHX2LIM homeobox 2. (406 aa)
SOX9SRY-box transcription factor 9. (522 aa)
DVL1Dishevelled segment polarity protein 1. (691 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
TCAPTitin-cap. (167 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2564 aa)
CLUAP1Clusterin associated protein 1. (437 aa)
CTHRC1Collagen triple helix repeat containing 1. (282 aa)
M3YUX6_MUSPFUncharacterized protein. (497 aa)
STK3Serine/threonine kinase 3. (418 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
IRX2Iroquois homeobox 2. (391 aa)
SCRIBScribble planar cell polarity protein. (1523 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
SHROOM3Shroom family member 3. (1723 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1285 aa)
ST14Suppression of tumorigenicity 14. (859 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (521 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (462 aa)
PAX8Paired box 8. (462 aa)
IFT57Intraflagellar transport 57. (429 aa)
M3YFG7_MUSPFUncharacterized protein. (135 aa)
MTHFD1LMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (918 aa)
DVL2Dishevelled segment polarity protein 2. (734 aa)
KAT2ALysine acetyltransferase 2A. (869 aa)
GRHL3Grainyhead like transcription factor 3. (602 aa)
PHACTR4Phosphatase and actin regulator. (708 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
LOC101676600Homeobox domain-containing protein. (185 aa)
M3Z3T6_MUSPFHomeobox domain-containing protein. (184 aa)
COBLCordon-bleu WH2 repeat protein. (1316 aa)
RALARAS like proto-oncogene A. (206 aa)
CECR2CECR2 histone acetyl-lysine reader. (1368 aa)
SPINT2Serine peptidase inhibitor, Kunitz type, 2. (252 aa)
IFT52Intraflagellar transport 52. (446 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
STK4Serine/threonine kinase 4. (487 aa)
SALL4Spalt like transcription factor 4. (1097 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1028 aa)
BBS4Bardet-Biedl syndrome 4. (507 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (484 aa)
M3YZI9_MUSPFHomeobox domain-containing protein. (197 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
GATA3GATA binding protein 3. (444 aa)
PRICKLE1Prickle planar cell polarity protein 1. (832 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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