STRINGSTRING
CDK4 CDK4 NCAPH2 NCAPH2 GLI1 GLI1 RB1 RB1 CUL4B CUL4B NSMCE2 NSMCE2 MTBP MTBP ADAMTS1 ADAMTS1 RAD21 RAD21 PBK PBK M3XP59_MUSPF M3XP59_MUSPF M3XP56_MUSPF M3XP56_MUSPF EDN1 EDN1 CD28 CD28 RAB11A RAB11A DRD3 DRD3 ATRX ATRX GEN1 GEN1 ROCK2 ROCK2 SPHK1 SPHK1 LSM11 LSM11 CCND3 CCND3 THOC5 THOC5 CENPJ CENPJ RRM2 RRM2 PDGFB PDGFB AFMID AFMID BIRC5 BIRC5 CPSF3 CPSF3 M3YP04_MUSPF M3YP04_MUSPF M3YP02_MUSPF M3YP02_MUSPF SVIL SVIL CEP120 CEP120 MAD2L1BP MAD2L1BP SH2B1 SH2B1 DDX3X DDX3X STIL STIL M3YLP8_MUSPF M3YLP8_MUSPF SASS6 SASS6 CDC14A CDC14A TPR TPR PRKCE PRKCE IGF1 IGF1 RPTOR RPTOR DYNC1LI1 DYNC1LI1 CRNN CRNN PPP1R10 PPP1R10 KAT5 KAT5 DDX39B DDX39B M3YIU0_MUSPF M3YIU0_MUSPF AIF1 AIF1 FAM178B FAM178B CDK1 CDK1 GIPC2 GIPC2 CEP295 CEP295 FBXO5 FBXO5 RRM1 RRM1 KIF14 KIF14 UBXN2B UBXN2B NUMA1 NUMA1 PCID2 PCID2 CSPP1 CSPP1 M3YFG2_MUSPF M3YFG2_MUSPF BECN1 BECN1 DYRK3 DYRK3 MACROH2A1 MACROH2A1 M3YEZ0_MUSPF M3YEZ0_MUSPF CUL4A CUL4A NCAPG2 NCAPG2 TFDP1 TFDP1 SMC5 SMC5 CDC23 CDC23 CDC25C CDC25C RHNO1 RHNO1 SOX15 SOX15 M3YD44_MUSPF M3YD44_MUSPF ANKRD17 ANKRD17 M3YCR5_MUSPF M3YCR5_MUSPF CDC16 CDC16 EPGN EPGN EREG EREG BTC BTC MECP2 MECP2 ANXA1 ANXA1 MTA3 MTA3 M3YBR7_MUSPF M3YBR7_MUSPF INO80 INO80 CDC25B CDC25B INSR INSR MAPK15 MAPK15 AURKB AURKB CDC27 CDC27 MSX1 MSX1 M3Y8U7_MUSPF M3Y8U7_MUSPF M3Y7A6_MUSPF M3Y7A6_MUSPF RAB11B RAB11B RAD51B RAD51B TGFA TGFA EZH2 EZH2 SMPD3 SMPD3 SMC2 SMC2 M3Y687_MUSPF M3Y687_MUSPF M3Y652_MUSPF M3Y652_MUSPF M3Y513_MUSPF M3Y513_MUSPF BHMG1 BHMG1 RHOA RHOA E2F8 E2F8 SPAG5 SPAG5 FGF10 FGF10 RACGAP1 RACGAP1 ATAD5 ATAD5 WNT10B WNT10B CDC6 CDC6 M3YU10_MUSPF M3YU10_MUSPF CDC25A CDC25A M3YU90_MUSPF M3YU90_MUSPF KLHL18 KLHL18 TBX2 TBX2 RRM2B RRM2B RAD51C RAD51C STXBP4 STXBP4 M3Y2T5_MUSPF M3Y2T5_MUSPF MEPCE MEPCE PPP1R35 PPP1R35 HNRNPU HNRNPU DTL DTL M3YX33_MUSPF M3YX33_MUSPF RCC2 RCC2 FBXO42 FBXO42 VPS4B VPS4B CUL3 CUL3 PHB2 PHB2 SLF2 SLF2 ECT2 ECT2 SIN3A SIN3A PLK4 PLK4 MAD2L1 MAD2L1 E2F7 E2F7 MDM2 MDM2 M3Z1P4_MUSPF M3Z1P4_MUSPF FAM83D FAM83D PAF1 PAF1 SIRT2 SIRT2 MAD1L1 MAD1L1 NSFL1C NSFL1C EGFR EGFR KMT2E KMT2E DBF4 DBF4 LSM10 LSM10 M3Z4V0_MUSPF M3Z4V0_MUSPF M3Z575_MUSPF M3Z575_MUSPF M3Z5C9_MUSPF M3Z5C9_MUSPF M3Z5K9_MUSPF M3Z5K9_MUSPF M3Z5V4_MUSPF M3Z5V4_MUSPF NUP62 NUP62 RHOB RHOB MAP10 MAP10 HSPA2 HSPA2 NEUROG1 NEUROG1 MBLAC1 MBLAC1 FEN1 FEN1 IGF2 IGF2 INS INS PLRG1 PLRG1 THOC1 THOC1 NDC80 NDC80 DMRT1 DMRT1 RHOC RHOC CXCR5 CXCR5 HOXA13 HOXA13 PKN2 PKN2 CDC73 CDC73 STOX1 STOX1 CCND1 CCND1 CDC7 CDC7 OOEP OOEP LRP5 LRP5 M3XYN0_MUSPF M3XYN0_MUSPF SLF1 SLF1 M3XYE2_MUSPF M3XYE2_MUSPF STRA8 STRA8 NPM2 NPM2 GIPC3 GIPC3 DRD2 DRD2 M3XXC5_MUSPF M3XXC5_MUSPF PIWIL2 PIWIL2 DDX39A DDX39A GIPC1 GIPC1 CIT CIT SMC4 SMC4 DYNC1H1 DYNC1H1 GPSM2 GPSM2 XRCC3 XRCC3 NCAPG NCAPG ANAPC7 ANAPC7 ANAPC5 ANAPC5 M3XSL4_MUSPF M3XSL4_MUSPF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (305 aa)
NCAPH2Non-SMC condensin II complex subunit H2. (555 aa)
GLI1GLI family zinc finger 1. (1105 aa)
RB1RB transcriptional corepressor 1. (948 aa)
CUL4BCullin 4B; Belongs to the cullin family. (1041 aa)
NSMCE2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (275 aa)
MTBPMDM2 binding protein. (893 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (953 aa)
RAD21RAD21 cohesin complex component. (631 aa)
PBKPDZ binding kinase. (323 aa)
M3XP59_MUSPFSAM domain-containing protein. (355 aa)
M3XP56_MUSPFProtein kinase domain-containing protein. (158 aa)
EDN1Endothelin 1. (202 aa)
CD28CD28 molecule. (255 aa)
RAB11ARAB11A, member RAS oncogene family. (216 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (447 aa)
ATRXATRX chromatin remodeler. (2784 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (907 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1389 aa)
SPHK1Sphingosine kinase 1. (386 aa)
LSM11Uncharacterized protein. (165 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (294 aa)
THOC5THO complex 5. (683 aa)
CENPJCentromere protein J. (1360 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (392 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (242 aa)
AFMIDKynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (307 aa)
BIRC5Baculoviral IAP repeat containing 5. (142 aa)
CPSF3Cleavage and polyadenylation specific factor 3. (684 aa)
M3YP04_MUSPFUncharacterized protein. (675 aa)
M3YP02_MUSPFPCAF_N domain-containing protein. (92 aa)
SVILSupervillin. (2245 aa)
CEP120Centrosomal protein 120. (963 aa)
MAD2L1BPMAD2L1 binding protein. (281 aa)
SH2B1SH2B adaptor protein 1. (757 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (662 aa)
STILSTIL centriolar assembly protein. (1275 aa)
M3YLP8_MUSPFUncharacterized protein. (433 aa)
SASS6SAS-6 centriolar assembly protein. (657 aa)
CDC14ACell division cycle 14A. (610 aa)
TPRTranslocated promoter region, nuclear basket protein. (2439 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
IGF1Insulin like growth factor 1. (153 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1244 aa)
DYNC1LI1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (524 aa)
CRNNCornulin. (542 aa)
PPP1R10Protein phosphatase 1 regulatory subunit 10. (956 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
DDX39BDExD-box helicase 39B. (428 aa)
M3YIU0_MUSPFRING-type domain-containing protein. (84 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
FAM178BFamily with sequence similarity 178 member B. (654 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
GIPC2GIPC PDZ domain containing family member 2. (312 aa)
CEP295Centrosomal protein 295. (2448 aa)
FBXO5F-box protein 5. (386 aa)
RRM1Ribonucleotide reductase catalytic subunit M1. (518 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1662 aa)
UBXN2BUBX domain protein 2B. (330 aa)
NUMA1Nuclear mitotic apparatus protein 1. (1792 aa)
PCID2PCI domain containing 2. (390 aa)
CSPP1Centrosome and spindle pole associated protein 1. (1177 aa)
M3YFG2_MUSPFGFA domain-containing protein. (169 aa)
BECN1Beclin 1. (448 aa)
DYRK3Dual specificity tyrosine phosphorylation regulated kinase 3. (587 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
M3YEZ0_MUSPFRAD51_interact domain-containing protein. (326 aa)
CUL4ACullin 4A; Belongs to the cullin family. (713 aa)
NCAPG2Non-SMC condensin II complex subunit G2. (1138 aa)
TFDP1Transcription factor. (410 aa)
SMC5SMC_N domain-containing protein. (1026 aa)
CDC23Cell division cycle 23. (590 aa)
CDC25CCell division cycle 25C. (491 aa)
RHNO1RAD9-HUS1-RAD1 interacting nuclear orphan 1. (255 aa)
SOX15SRY-box transcription factor 15. (233 aa)
M3YD44_MUSPFCyclin N-terminal domain-containing protein; Belongs to the cyclin family. (291 aa)
ANKRD17Ankyrin repeat domain 17. (2491 aa)
M3YCR5_MUSPFUncharacterized protein. (264 aa)
CDC16Cell division cycle 16. (605 aa)
EPGNEpithelial mitogen. (153 aa)
EREGEpiregulin. (161 aa)
BTCBetacellulin. (185 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (484 aa)
ANXA1Annexin. (345 aa)
MTA3Metastasis associated 1 family member 3. (621 aa)
M3YBR7_MUSPFUncharacterized protein. (441 aa)
INO80INO80 complex ATPase subunit. (1561 aa)
CDC25BCell division cycle 25B. (515 aa)
INSRTyrosine-protein kinase receptor. (1352 aa)
MAPK15Mitogen-activated protein kinase. (550 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (344 aa)
CDC27Cell division cycle 27. (825 aa)
MSX1Msh homeobox 1. (303 aa)
M3Y8U7_MUSPFCDT1 domain-containing protein. (347 aa)
M3Y7A6_MUSPFRad51 domain-containing protein. (120 aa)
RAB11BRAB11B, member RAS oncogene family. (218 aa)
RAD51BRAD51 paralog B. (281 aa)
TGFATransforming growth factor alpha. (158 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (753 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (658 aa)
SMC2Structural maintenance of chromosomes protein. (1191 aa)
M3Y687_MUSPFUncharacterized protein. (493 aa)
M3Y652_MUSPFUncharacterized protein. (633 aa)
M3Y513_MUSPFUncharacterized protein. (907 aa)
BHMG1Basic helix-loop-helix and HMG-box containing 1. (584 aa)
RHOARas homolog family member A. (193 aa)
E2F8E2F transcription factor 8. (860 aa)
SPAG5Sperm associated antigen 5. (1197 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
RACGAP1Rac GTPase activating protein 1. (631 aa)
ATAD5ATPase family AAA domain containing 5. (1892 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (558 aa)
M3YU10_MUSPFRRM domain-containing protein. (311 aa)
CDC25ACell division cycle 25A. (476 aa)
M3YU90_MUSPFMediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (616 aa)
KLHL18Kelch like family member 18. (574 aa)
TBX2T-box transcription factor 2. (679 aa)
RRM2BRibonucleotide reductase regulatory TP53 inducible subunit M2B. (351 aa)
RAD51CRAD51 paralog C. (371 aa)
STXBP4Syntaxin binding protein 4. (522 aa)
M3Y2T5_MUSPFRAMA domain-containing protein. (491 aa)
MEPCEMethylphosphate capping enzyme. (693 aa)
PPP1R35Protein phosphatase 1 regulatory subunit 35. (305 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (592 aa)
DTLDenticleless E3 ubiquitin protein ligase homolog. (730 aa)
M3YX33_MUSPFUncharacterized protein. (191 aa)
RCC2Regulator of chromosome condensation 2. (427 aa)
FBXO42F-box protein 42. (717 aa)
VPS4BVacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (422 aa)
CUL3Cullin 3; Belongs to the cullin family. (746 aa)
PHB2Prohibitin. (299 aa)
SLF2SMC5-SMC6 complex localization factor 2. (1173 aa)
ECT2Epithelial cell transforming 2. (914 aa)
SIN3ASIN3 transcription regulator family member A. (1550 aa)
PLK4Polo like kinase 4. (968 aa)
MAD2L1Mitotic arrest deficient 2 like 1. (205 aa)
E2F7E2F transcription factor 7. (899 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
M3Z1P4_MUSPFUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (181 aa)
FAM83DFamily with sequence similarity 83 member D. (621 aa)
PAF1PAF1 homolog, Paf1/RNA polymerase II complex component. (554 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (412 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (737 aa)
NSFL1CNSFL1 cofactor. (370 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
KMT2ELysine methyltransferase 2E. (1860 aa)
DBF4DBF4 zinc finger. (683 aa)
LSM10LSM10, U7 small nuclear RNA associated. (123 aa)
M3Z4V0_MUSPFRanBD1 domain-containing protein. (208 aa)
M3Z575_MUSPFUBIQUITIN_CONJUGAT_2 domain-containing protein. (179 aa)
M3Z5C9_MUSPFUBIQUITIN_CONJUGAT_2 domain-containing protein. (179 aa)
M3Z5K9_MUSPFGFA domain-containing protein. (261 aa)
M3Z5V4_MUSPFRanBD1 domain-containing protein. (209 aa)
NUP62Nucleoporin 62. (527 aa)
RHOBRas homolog family member B. (196 aa)
MAP10Microtubule associated protein 10. (848 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (635 aa)
NEUROG1Neurogenin 1. (247 aa)
MBLAC1Metallo-beta-lactamase domain containing 1. (248 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
IGF2Insulin like growth factor 2. (192 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (109 aa)
PLRG1Pleiotropic regulator 1. (515 aa)
THOC1THO complex 1. (657 aa)
NDC80NDC80 kinetochore complex component. (642 aa)
DMRT1Doublesex and mab-3 related transcription factor 1. (324 aa)
RHOCRas homolog family member C. (193 aa)
CXCR5C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (374 aa)
HOXA13Homeobox A13. (259 aa)
PKN2Protein kinase N2. (983 aa)
CDC73Cell division cycle 73. (531 aa)
STOX1Storkhead box 1. (876 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
CDC7Cell division cycle 7. (575 aa)
OOEPOocyte expressed protein. (149 aa)
LRP5Uncharacterized protein. (1465 aa)
M3XYN0_MUSPFUncharacterized protein. (192 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1145 aa)
M3XYE2_MUSPFRanBD1 domain-containing protein. (209 aa)
STRA8Stimulated by retinoic acid 8. (451 aa)
NPM2Nucleophosmin/nucleoplasmin 2. (221 aa)
GIPC3GIPC PDZ domain containing family member 3. (252 aa)
DRD2D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. (443 aa)
M3XXC5_MUSPFNsp1_C domain-containing protein. (267 aa)
PIWIL2Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (970 aa)
DDX39ADExD-box helicase 39A. (427 aa)
GIPC1GIPC PDZ domain containing family member 1. (333 aa)
CITCitron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2069 aa)
SMC4Structural maintenance of chromosomes protein. (1288 aa)
DYNC1H1Dynein cytoplasmic 1 heavy chain 1. (4469 aa)
GPSM2G protein signaling modulator 2. (681 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (349 aa)
NCAPGNon-SMC condensin I complex subunit G. (1014 aa)
ANAPC7Anaphase promoting complex subunit 7. (598 aa)
ANAPC5Anaphase promoting complex subunit 5. (711 aa)
M3XSL4_MUSPFUncharacterized protein. (443 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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