STRINGSTRING
ABL1 ABL1 TOB1 TOB1 SPRY4 SPRY4 GREM1 GREM1 NOG NOG SPRY1 SPRY1 SPRY2 SPRY2 VWC2 VWC2 SULF2 SULF2 PTPN1 PTPN1 LEMD3 LEMD3 SKIL SKIL SLIT2 SLIT2 NANOG NANOG SMURF1 SMURF1 GATA3 GATA3 CXCL13 CXCL13 NBL1 NBL1 GREM2 GREM2 NGFR NGFR BAMBI BAMBI SMURF2 SMURF2 WNT1 WNT1 SOSTDC1 SOSTDC1 TMPRSS6 TMPRSS6 CASK CASK FBN1 FBN1 ATP2B4 ATP2B4 HGS HGS NOTCH1 NOTCH1 CTDSPL2 CTDSPL2 SULF1 SULF1 M3YGU3_MUSPF M3YGU3_MUSPF HTRA3 HTRA3 PDCD6 PDCD6 CRIM1 CRIM1 ADGRA2 ADGRA2 FSTL3 FSTL3 SOST SOST EMILIN1 EMILIN1 CHRDL2 CHRDL2 PIK3CB PIK3CB MMRN2 MMRN2 THBS1 THBS1 VWC2L VWC2L SKI SKI DCN DCN DAB2IP DAB2IP SHISA2 SHISA2 PPM1A PPM1A M3Y377_MUSPF M3Y377_MUSPF SORL1 SORL1 CREB3L1 CREB3L1 BMPER BMPER SFRP2 SFRP2 TRIM33 TRIM33 TWSG1 TWSG1 AGT AGT CHRDL1 CHRDL1 HIPK2 HIPK2 HRG HRG LEMD2 LEMD2 CHRD CHRD SPART SPART M3XP47_MUSPF M3XP47_MUSPF SMAD7 SMAD7 DLX1 DLX1 HJV HJV SEMA6A SEMA6A LRP2 LRP2 RBPMS2 RBPMS2 TNFAIP6 TNFAIP6 SMAD6 SMAD6 SKOR1 SKOR1 GPC1 GPC1 EPN2 EPN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABL1Tyrosine-protein kinase. (1150 aa)
TOB1Transducer of ERBB2, 1. (345 aa)
SPRY4Sprouty RTK signaling antagonist 4. (299 aa)
GREM1Gremlin. (184 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SPRY1Sprouty-like protein 1, antagonist of FGF signaling. (319 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
VWC2Von Willebrand factor C domain containing 2. (275 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (954 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (424 aa)
LEMD3LEM domain containing 3. (901 aa)
SKILSKI like proto-oncogene. (664 aa)
SLIT2Slit guidance ligand 2. (1539 aa)
NANOGHomeobox domain-containing protein. (310 aa)
SMURF1E3 ubiquitin-protein ligase. (725 aa)
GATA3GATA binding protein 3. (444 aa)
CXCL13C-X-C motif chemokine. (109 aa)
NBL1NBL1, DAN family BMP antagonist. (175 aa)
GREM2Gremlin. (177 aa)
NGFRNerve growth factor receptor. (429 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
SMURF2E3 ubiquitin-protein ligase. (739 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (340 aa)
SOSTDC1Sclerostin domain containing 1. (209 aa)
TMPRSS6Transmembrane serine protease 6; Belongs to the peptidase S1 family. (805 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (929 aa)
FBN1Fibrillin 1. (2877 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1206 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (780 aa)
NOTCH1Notch receptor 1. (2119 aa)
CTDSPL2CTD small phosphatase like 2. (466 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (867 aa)
M3YGU3_MUSPFUncharacterized protein. (267 aa)
HTRA3HtrA serine peptidase 3. (431 aa)
PDCD6Programmed cell death 6. (189 aa)
CRIM1Cysteine rich transmembrane BMP regulator 1. (1034 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1280 aa)
FSTL3Follistatin like 3. (260 aa)
SOSTSclerostin. (213 aa)
EMILIN1Elastin microfibril interfacer 1. (1016 aa)
CHRDL2Chordin like 2. (430 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MMRN2Multimerin 2. (925 aa)
THBS1Thrombospondin 1. (1170 aa)
VWC2LVon Willebrand factor C domain containing 2 like. (222 aa)
SKISKI proto-oncogene. (680 aa)
DCNDecorin; May affect the rate of fibrils formation. (360 aa)
DAB2IPDAB2 interacting protein. (1112 aa)
SHISA2Shisa family member 2. (295 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
M3Y377_MUSPFNTR domain-containing protein. (233 aa)
SORL1Sortilin related receptor 1. (2211 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
BMPERBMP binding endothelial regulator. (685 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
TRIM33Tripartite motif containing 33. (1055 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (184 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
CHRDL1Chordin like 1. (458 aa)
HIPK2Homeodomain interacting protein kinase 2. (1165 aa)
HRGHistidine rich glycoprotein. (534 aa)
LEMD2LEM domain containing 2. (295 aa)
CHRDChordin. (882 aa)
SPARTSpartin. (732 aa)
M3XP47_MUSPFUncharacterized protein. (547 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
DLX1Distal-less homeobox 1. (255 aa)
HJVHemojuvelin BMP co-receptor. (426 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1031 aa)
LRP2LDL receptor related protein 2. (4699 aa)
RBPMS2RNA binding protein, mRNA processing factor 2. (200 aa)
TNFAIP6TNF alpha induced protein 6. (277 aa)
SMAD6Mothers against decapentaplegic homolog. (494 aa)
SKOR1SKI family transcriptional corepressor 1. (921 aa)
GPC1Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (558 aa)
EPN2Epsin 2. (583 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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