(53 nodes) Regulation of protein deacetylation network (Mustela putorius)

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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experimentally determined

Predicted Interactions

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protein homology

Your Input:
	LRRK2	Leucine rich repeat kinase 2. (2527 aa)
	M3XSA1_MUSPF	Uncharacterized protein. (663 aa)
	M3XSA5_MUSPF	Uncharacterized protein. (2429 aa)
	YEATS2	YEATS domain containing 2. (1403 aa)
	BRMS1	BRMS1 transcriptional repressor and anoikis regulator. (246 aa)
	BCL6	BCL6 transcription repressor. (706 aa)
	CCAR2	Cell cycle and apoptosis regulator 2. (925 aa)
	SPHK2	Sphingosine kinase 2. (673 aa)
	DR1	Down-regulator of transcription 1. (175 aa)
	PRKD2	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
	PRKD1	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (824 aa)
	RRP8	Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (454 aa)
	ZBTB7B	Zinc finger and BTB domain containing 7B. (537 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (524 aa)
	SPRED1	Sprouty related EVH1 domain containing 1. (443 aa)
	DYRK1A	Dual specificity tyrosine phosphorylation regulated kinase 1A. (754 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
	JDP2	Jun dimerization protein 2. (214 aa)
	M3YD94_MUSPF	SLIDE domain-containing protein. (67 aa)
	M3YD97_MUSPF	HAND domain-containing protein. (88 aa)
	M3YDA0_MUSPF	Helicase C-terminal domain-containing protein. (105 aa)
	M3YDA5_MUSPF	Helicase ATP-binding domain-containing protein. (91 aa)
	UCN	Urocortin. (126 aa)
	NCAPG2	Non-SMC condensin II complex subunit G2. (1138 aa)
	TPPP	Tubulin polymerization promoting protein. (221 aa)
	SDR16C5	Short chain dehydrogenase/reductase family 16C member 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa)
	KAT2A	Lysine acetyltransferase 2A. (869 aa)
	M3YHC9_MUSPF	Uncharacterized protein. (903 aa)
	ING2	Inhibitor of growth protein. (239 aa)
	CTBP1	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (429 aa)
	SIRT1	Sirtuin 1. (557 aa)
	WDR5	WD repeat domain 5. (334 aa)
	SGF29	SAGA complex associated factor 29. (293 aa)
	FNTA	Farnesyltransferase, CAAX box, alpha. (418 aa)
	SAP30BP	SAP30 binding protein. (308 aa)
	FOXP3	Forkhead box P3. (433 aa)
	C6orf89	Chromosome 6 open reading frame 89. (355 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (517 aa)
	NIPBL	Nipped-B protein. (2803 aa)
	TADA2A	Transcriptional adapter. (443 aa)
	AKAP8L	A-kinase anchoring protein 8 like; Belongs to the AKAP95 family. (708 aa)
	PINK1	PTEN induced kinase 1. (580 aa)
	MBIP	MAP3K12 binding inhibitory protein 1. (344 aa)
	EP300	E1A binding protein p300. (2425 aa)
	TADA3	Transcriptional adaptor 3. (384 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
	TGFB1	Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
	NEK3	NIMA related kinase 3. (504 aa)
	APLNR	Apelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
	BEX4	Brain expressed X-linked 4. (120 aa)
	PRMT6	Protein arginine methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (375 aa)
	NDN	Necdin, MAGE family member. (325 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL6	EP300	ENSMPUP00000003385	ENSMPUP00000016323	BCL6 transcription repressor.	E1A binding protein p300.	0.428
BCL6	FOXP3	ENSMPUP00000003385	ENSMPUP00000013948	BCL6 transcription repressor.	Forkhead box P3.	0.817
BCL6	IFNG	ENSMPUP00000003385	ENSMPUP00000017401	BCL6 transcription repressor.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	0.550
BCL6	SIRT1	ENSMPUP00000003385	ENSMPUP00000011868	BCL6 transcription repressor.	Sirtuin 1.	0.502
BCL6	TP53	ENSMPUP00000003385	ENSMPUP00000008945	BCL6 transcription repressor.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.577
BRMS1	ING2	ENSMPUP00000002960	ENSMPUP00000010954	BRMS1 transcriptional repressor and anoikis regulator.	Inhibitor of growth protein.	0.751
CCAR2	SIRT1	ENSMPUP00000003456	ENSMPUP00000011868	Cell cycle and apoptosis regulator 2.	Sirtuin 1.	0.887
DR1	KAT2A	ENSMPUP00000003992	ENSMPUP00000010482	Down-regulator of transcription 1.	Lysine acetyltransferase 2A.	0.708
DR1	M3YHC9_MUSPF	ENSMPUP00000003992	ENSMPUP00000010736	Down-regulator of transcription 1.	Uncharacterized protein.	0.778
DR1	MBIP	ENSMPUP00000003992	ENSMPUP00000016161	Down-regulator of transcription 1.	MAP3K12 binding inhibitory protein 1.	0.881
DR1	SGF29	ENSMPUP00000003992	ENSMPUP00000012575	Down-regulator of transcription 1.	SAGA complex associated factor 29.	0.905
DR1	TADA2A	ENSMPUP00000003992	ENSMPUP00000014929	Down-regulator of transcription 1.	Transcriptional adapter.	0.936
DR1	TADA3	ENSMPUP00000003992	ENSMPUP00000017016	Down-regulator of transcription 1.	Transcriptional adaptor 3.	0.882
DR1	WDR5	ENSMPUP00000003992	ENSMPUP00000012088	Down-regulator of transcription 1.	WD repeat domain 5.	0.778
DR1	YEATS2	ENSMPUP00000003992	ENSMPUP00000002367	Down-regulator of transcription 1.	YEATS domain containing 2.	0.906
DYRK1A	EP300	ENSMPUP00000008392	ENSMPUP00000016323	Dual specificity tyrosine phosphorylation regulated kinase 1A.	E1A binding protein p300.	0.464
DYRK1A	TP53	ENSMPUP00000008392	ENSMPUP00000008945	Dual specificity tyrosine phosphorylation regulated kinase 1A.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.556
EP300	BCL6	ENSMPUP00000016323	ENSMPUP00000003385	E1A binding protein p300.	BCL6 transcription repressor.	0.428
EP300	DYRK1A	ENSMPUP00000016323	ENSMPUP00000008392	E1A binding protein p300.	Dual specificity tyrosine phosphorylation regulated kinase 1A.	0.464
EP300	ING2	ENSMPUP00000016323	ENSMPUP00000010954	E1A binding protein p300.	Inhibitor of growth protein.	0.933