(27 nodes) Extrinsic apoptotic signaling pathway in absence of ligand network (Mustela putorius)

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second shell of interactors

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Your Input:
	BOK	BCL2 family apoptosis regulator BOK. (213 aa)
	COL2A1	Collagen type II alpha 1 chain. (1486 aa)
	ERBB3	Erb-b2 receptor tyrosine kinase 3. (1339 aa)
	BAK1	BCL2 antagonist/killer 1. (211 aa)
	BAG3	BCL2 associated athanogene 3. (597 aa)
	BAX	BCL2 associated X, apoptosis regulator. (192 aa)
	ITGAV	Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
	MCL1	MCL1 apoptosis regulator, BCL2 family member. (350 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (216 aa)
	FAS	Fas cell surface death receptor. (311 aa)
	BCL2L2	BCL2 like 2. (219 aa)
	CASP2	Caspase 2; Belongs to the peptidase C14A family. (452 aa)
	M3Y830_MUSPF	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (417 aa)
	KITLG	KIT ligand. (274 aa)
	M3Y8D1_MUSPF	Uncharacterized protein. (226 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
	BCL2L11	BCL2 like 11. (232 aa)
	FOXO3	Forkhead box O3. (671 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
	BAD	BCL2 associated agonist of cell death. (168 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	NF1	Neurofibromin 1. (2815 aa)
	BCL2A1	BCL2 related protein A1. (174 aa)
	BCL2	BCL2 apoptosis regulator. (207 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (152 aa)
	EYA2	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (533 aa)
	BCL2L1	BCL2 like 1. (233 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAD	BAK1	ENSMPUP00000012854	ENSMPUP00000002412	BCL2 associated agonist of cell death.	BCL2 antagonist/killer 1.	0.834
BAD	BAX	ENSMPUP00000012854	ENSMPUP00000003276	BCL2 associated agonist of cell death.	BCL2 associated X, apoptosis regulator.	0.842
BAD	BCL2	ENSMPUP00000012854	ENSMPUP00000016413	BCL2 associated agonist of cell death.	BCL2 apoptosis regulator.	0.990
BAD	BCL2A1	ENSMPUP00000012854	ENSMPUP00000015334	BCL2 associated agonist of cell death.	BCL2 related protein A1.	0.743
BAD	BCL2L1	ENSMPUP00000012854	ENSMPUP00000017791	BCL2 associated agonist of cell death.	BCL2 like 1.	0.998
BAD	BCL2L11	ENSMPUP00000012854	ENSMPUP00000009390	BCL2 associated agonist of cell death.	BCL2 like 11.	0.899
BAD	BCL2L2	ENSMPUP00000012854	ENSMPUP00000006726	BCL2 associated agonist of cell death.	BCL2 like 2.	0.887
BAD	BOK	ENSMPUP00000012854	ENSMPUP00000000176	BCL2 associated agonist of cell death.	BCL2 family apoptosis regulator BOK.	0.812
BAD	CASP2	ENSMPUP00000012854	ENSMPUP00000006916	BCL2 associated agonist of cell death.	Caspase 2; Belongs to the peptidase C14A family.	0.530
BAD	FADD	ENSMPUP00000012854	ENSMPUP00000004665	BCL2 associated agonist of cell death.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.543
BAD	M3Y8D1_MUSPF	ENSMPUP00000012854	ENSMPUP00000007588	BCL2 associated agonist of cell death.	Uncharacterized protein.	0.875
BAD	MCL1	ENSMPUP00000012854	ENSMPUP00000004646	BCL2 associated agonist of cell death.	MCL1 apoptosis regulator, BCL2 family member.	0.778
BAG3	BCL2	ENSMPUP00000003026	ENSMPUP00000016413	BCL2 associated athanogene 3.	BCL2 apoptosis regulator.	0.794
BAK1	BAD	ENSMPUP00000002412	ENSMPUP00000012854	BCL2 antagonist/killer 1.	BCL2 associated agonist of cell death.	0.834
BAK1	BAX	ENSMPUP00000002412	ENSMPUP00000003276	BCL2 antagonist/killer 1.	BCL2 associated X, apoptosis regulator.	0.968
BAK1	BCL2	ENSMPUP00000002412	ENSMPUP00000016413	BCL2 antagonist/killer 1.	BCL2 apoptosis regulator.	0.982
BAK1	BCL2A1	ENSMPUP00000002412	ENSMPUP00000015334	BCL2 antagonist/killer 1.	BCL2 related protein A1.	0.932
BAK1	BCL2L1	ENSMPUP00000002412	ENSMPUP00000017791	BCL2 antagonist/killer 1.	BCL2 like 1.	0.997
BAK1	BCL2L11	ENSMPUP00000002412	ENSMPUP00000009390	BCL2 antagonist/killer 1.	BCL2 like 11.	0.965
BAK1	BCL2L2	ENSMPUP00000002412	ENSMPUP00000006726	BCL2 antagonist/killer 1.	BCL2 like 2.	0.947