(50 nodes) Cellular response to alcohol network (Mustela putorius)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1130 aa)
	CFTR	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1484 aa)
	PTCH1	Patched 1. (1386 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (790 aa)
	GRAMD1B	GRAM domain containing 1B. (754 aa)
	M3Y377_MUSPF	NTR domain-containing protein. (233 aa)
	ADAM15	ADAM metallopeptidase domain 15. (860 aa)
	PTGER2	Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (354 aa)
	GPLD1	Glycosylphosphatidylinositol specific phospholipase D1. (875 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1018 aa)
	SPHK2	Sphingosine kinase 2. (673 aa)
	ACACB	Acetyl-CoA carboxylase beta. (2456 aa)
	M3XW62_MUSPF	Uncharacterized protein. (106 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
	NPAS4	Neuronal PAS domain protein 4. (800 aa)
	GLRA2	Glycine receptor alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (452 aa)
	MLC1	Modulator of VRAC current 1. (373 aa)
	M3XPZ1_MUSPF	DUF4503 domain-containing protein. (370 aa)
	M3XNQ3_MUSPF	DUF4502 domain-containing protein. (379 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	GRAMD1C	GRAM domain containing 1C. (661 aa)
	GRAMD1A	GRAM domain containing 1A. (806 aa)
	RAD51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa)
	TP53INP1	Tumor protein p53 inducible nuclear protein 1. (239 aa)
	P2RY6	Pyrimidinergic receptor P2Y6. (395 aa)
	EFNA5	Ephrin A5; Belongs to the ephrin family. (260 aa)
	PTGFR	Prostaglandin F receptor. (366 aa)
	JUP	Junction plakoglobin. (744 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	LRP6	LDL receptor related protein 6. (1462 aa)
	PRKCE	Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
	SCNN1G	Sodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (642 aa)
	LARP1	La ribonucleoprotein domain family member 1. (907 aa)
	GLRA1	Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (449 aa)
	RECQL5	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (986 aa)
	M3YRA0_MUSPF	Uncharacterized protein. (848 aa)
	PTRHD1	Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (517 aa)
	PTGER4	Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (489 aa)
	ACACA	Acetyl-CoA carboxylase alpha. (2383 aa)
	GOLPH3	Golgi phosphoprotein 3. (236 aa)
	OSBPL7	Oxysterol-binding protein; Belongs to the OSBP family. (838 aa)
	NFE2L1	Nuclear factor, erythroid 2 like 1. (834 aa)
	TNFSF4	TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
	BLM	BLM RecQ like helicase. (1221 aa)
	LOC101678026	CLLAC domain-containing protein. (571 aa)
	MAP4K1	Mitogen-activated protein kinase kinase kinase kinase 1; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (820 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (524 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	ACACB	ENSMPUP00000014932	ENSMPUP00000003515	Acetyl-CoA carboxylase alpha.	Acetyl-CoA carboxylase beta.	0.816
ACACA	PRKAA1	ENSMPUP00000014932	ENSMPUP00000014643	Acetyl-CoA carboxylase alpha.	Non-specific serine/threonine protein kinase.	0.871
ACACA	PRKAA2	ENSMPUP00000014932	ENSMPUP00000007189	Acetyl-CoA carboxylase alpha.	Non-specific serine/threonine protein kinase.	0.907
ACACB	ACACA	ENSMPUP00000003515	ENSMPUP00000014932	Acetyl-CoA carboxylase beta.	Acetyl-CoA carboxylase alpha.	0.816
ACACB	PRKAA1	ENSMPUP00000003515	ENSMPUP00000014643	Acetyl-CoA carboxylase beta.	Non-specific serine/threonine protein kinase.	0.871
ACACB	PRKAA2	ENSMPUP00000003515	ENSMPUP00000007189	Acetyl-CoA carboxylase beta.	Non-specific serine/threonine protein kinase.	0.907
ADCY1	ADCY3	ENSMPUP00000018070	ENSMPUP00000013920	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.833
ADCY1	ADCY5	ENSMPUP00000018070	ENSMPUP00000004470	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.548
ADCY1	ADCY6	ENSMPUP00000018070	ENSMPUP00000014639	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.550
ADCY1	ADCY7	ENSMPUP00000018070	ENSMPUP00000003122	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.655
ADCY1	PTRHD1	ENSMPUP00000018070	ENSMPUP00000013910	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Peptidyl-tRNA hydrolase domain containing 1.	0.833
ADCY3	ADCY1	ENSMPUP00000013920	ENSMPUP00000018070	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.833
ADCY3	ADCY5	ENSMPUP00000013920	ENSMPUP00000004470	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.435
ADCY3	ADCY6	ENSMPUP00000013920	ENSMPUP00000014639	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.842
ADCY3	ADCY7	ENSMPUP00000013920	ENSMPUP00000003122	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.424
ADCY5	ADCY1	ENSMPUP00000004470	ENSMPUP00000018070	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.548
ADCY5	ADCY3	ENSMPUP00000004470	ENSMPUP00000013920	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.435
ADCY5	ADCY6	ENSMPUP00000004470	ENSMPUP00000014639	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.925
ADCY5	ADCY7	ENSMPUP00000004470	ENSMPUP00000003122	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.767
ADCY5	PTRHD1	ENSMPUP00000004470	ENSMPUP00000013910	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Peptidyl-tRNA hydrolase domain containing 1.	0.426