(43 nodes) General transcription initiation factor binding network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	M3XR81_MUSPF	NAC-A/B domain-containing protein. (2102 aa)
	TAF7L	TATA-box binding protein associated factor 7 like. (472 aa)
	YEATS2	YEATS domain containing 2. (1403 aa)
	RUVBL2	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
	THAP7	THAP domain containing 7. (313 aa)
	DR1	Down-regulator of transcription 1. (175 aa)
	GTF2B	General transcription factor IIB. (316 aa)
	M3Y136_MUSPF	Transcription initiation factor TFIID subunit. (1904 aa)
	ZNHIT6	Zinc finger HIT-type containing 6. (472 aa)
	BCL10	BCL10 immune signaling adaptor. (241 aa)
	ERCC1	ERCC excision repair 1, endonuclease non-catalytic subunit. (294 aa)
	POLR1E	RNA polymerase I subunit E. (471 aa)
	GTF2F1	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (517 aa)
	HSF1	Heat shock transcription factor 1. (555 aa)
	BRF1	BRF1 RNA polymerase III transcription initiation factor subunit. (562 aa)
	GTF2A1	General transcription factor IIA subunit 1. (376 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
	BRF2	BRF2 RNA polymerase III transcription initiation factor subunit. (421 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (597 aa)
	AR	Androgen receptor. (892 aa)
	EDF1	Endothelial differentiation related factor 1. (134 aa)
	DRAP1	DR1 associated protein 1. (185 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (511 aa)
	RPTOR	Regulatory associated protein of MTOR complex 1. (1244 aa)
	M3YNB9_MUSPF	Uncharacterized protein. (80 aa)
	M3YRA0_MUSPF	Uncharacterized protein. (848 aa)
	BDP1	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB. (2605 aa)
	ERCC4	ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
	PSMC5	Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
	TAF12	TATA-box binding protein associated factor 12. (195 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U. (592 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2552 aa)
	CTDP1	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (759 aa)
	CAND2	Cullin associated and neddylation dissociated 2 (putative). (1236 aa)
	BTAF1	B-TFIID TATA-box binding protein associated factor 1. (1855 aa)
	RUVBL1	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
	CAND1	Cullin associated and neddylation dissociated 1. (1230 aa)
	M3Z2N7_MUSPF	NAC-A/B domain-containing protein. (181 aa)
	ZBTB43	Zinc finger and BTB domain containing 43. (467 aa)
	TAF7	TATA-box binding protein associated factor 7. (364 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
	NOP58	NOP58 ribonucleoprotein. (539 aa)
	FOXF2	Forkhead box F2. (415 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	ESR1	ENSMPUP00000010444	ENSMPUP00000010404	Androgen receptor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.597
AR	RELA	ENSMPUP00000010444	ENSMPUP00000011545	Androgen receptor.	RELA proto-oncogene, NF-kB subunit.	0.464
AR	TP53	ENSMPUP00000010444	ENSMPUP00000008945	Androgen receptor.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.638
BCL10	RELA	ENSMPUP00000005407	ENSMPUP00000011545	BCL10 immune signaling adaptor.	RELA proto-oncogene, NF-kB subunit.	0.622
BDP1	BRF1	ENSMPUP00000014317	ENSMPUP00000008124	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB.	BRF1 RNA polymerase III transcription initiation factor subunit.	0.986
BDP1	BRF2	ENSMPUP00000014317	ENSMPUP00000009931	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB.	BRF2 RNA polymerase III transcription initiation factor subunit.	0.978
BDP1	BTAF1	ENSMPUP00000014317	ENSMPUP00000017120	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB.	B-TFIID TATA-box binding protein associated factor 1.	0.581
BDP1	M3Y136_MUSPF	ENSMPUP00000014317	ENSMPUP00000005037	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB.	Transcription initiation factor TFIID subunit.	0.406
BRF1	BDP1	ENSMPUP00000008124	ENSMPUP00000014317	BRF1 RNA polymerase III transcription initiation factor subunit.	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB.	0.986
BRF1	BRF2	ENSMPUP00000008124	ENSMPUP00000009931	BRF1 RNA polymerase III transcription initiation factor subunit.	BRF2 RNA polymerase III transcription initiation factor subunit.	0.501
BRF1	M3YNB9_MUSPF	ENSMPUP00000008124	ENSMPUP00000012826	BRF1 RNA polymerase III transcription initiation factor subunit.	Uncharacterized protein.	0.986
BRF2	BDP1	ENSMPUP00000009931	ENSMPUP00000014317	BRF2 RNA polymerase III transcription initiation factor subunit.	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB.	0.978
BRF2	BRF1	ENSMPUP00000009931	ENSMPUP00000008124	BRF2 RNA polymerase III transcription initiation factor subunit.	BRF1 RNA polymerase III transcription initiation factor subunit.	0.501
BRF2	M3YNB9_MUSPF	ENSMPUP00000009931	ENSMPUP00000012826	BRF2 RNA polymerase III transcription initiation factor subunit.	Uncharacterized protein.	0.978
BTAF1	BDP1	ENSMPUP00000017120	ENSMPUP00000014317	B-TFIID TATA-box binding protein associated factor 1.	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB.	0.581
BTAF1	DR1	ENSMPUP00000017120	ENSMPUP00000003992	B-TFIID TATA-box binding protein associated factor 1.	Down-regulator of transcription 1.	0.871
BTAF1	DRAP1	ENSMPUP00000017120	ENSMPUP00000011337	B-TFIID TATA-box binding protein associated factor 1.	DR1 associated protein 1.	0.899
BTAF1	GTF2B	ENSMPUP00000017120	ENSMPUP00000004760	B-TFIID TATA-box binding protein associated factor 1.	General transcription factor IIB.	0.469
BTAF1	M3Y136_MUSPF	ENSMPUP00000017120	ENSMPUP00000005037	B-TFIID TATA-box binding protein associated factor 1.	Transcription initiation factor TFIID subunit.	0.448
BTAF1	M3YNB9_MUSPF	ENSMPUP00000017120	ENSMPUP00000012826	B-TFIID TATA-box binding protein associated factor 1.	Uncharacterized protein.	0.581