STRINGSTRING
IL6 IL6 TREM2 TREM2 ADCY7 ADCY7 MYD88 MYD88 PDCD4 PDCD4 TLR4 TLR4 M3XRI4_MUSPF M3XRI4_MUSPF ABCD2 ABCD2 TREML1 TREML1 CHID1 CHID1 IL17A IL17A IL17F IL17F ABCD1 ABCD1 ANKRD42 ANKRD42 CCDC142 CCDC142 LEP LEP HIF1A HIF1A CLEC7A CLEC7A F2 F2 APOD APOD NOD2 NOD2 ALOX5 ALOX5 STAT3 STAT3 M3YGX4_MUSPF M3YGX4_MUSPF TNF TNF PYCARD PYCARD CARD9 CARD9 APPL2 APPL2 IL17B IL17B IL1R2 IL1R2 PLA2G3 PLA2G3 IL17RA IL17RA IL17RC IL17RC M3YZK9_MUSPF M3YZK9_MUSPF APPL1 APPL1 ZC3H12A ZC3H12A PLA2G10 PLA2G10 CD6 CD6 NOS2 NOS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
PDCD4Programmed cell death 4. (469 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
M3XRI4_MUSPFCUE domain-containing protein. (208 aa)
ABCD2ATP binding cassette subfamily D member 2. (742 aa)
TREML1Triggering receptor expressed on myeloid cells like 1. (314 aa)
CHID1Chitinase domain containing 1; Belongs to the glycosyl hydrolase 18 family. (393 aa)
IL17AInterleukin 17A. (153 aa)
IL17FUncharacterized protein. (140 aa)
ABCD1ATP binding cassette subfamily D member 1. (733 aa)
ANKRD42Ankyrin repeat domain 42. (348 aa)
CCDC142Coiled-coil domain containing 142. (768 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (824 aa)
CLEC7AC-type lectin domain containing 7A. (248 aa)
F2Coagulation factor II, thrombin; Belongs to the peptidase S1 family. (602 aa)
APODApolipoprotein D. (189 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1013 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
M3YGX4_MUSPFUncharacterized protein. (369 aa)
TNFTumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
PYCARDPYD and CARD domain containing. (193 aa)
CARD9Caspase recruitment domain family member 9. (478 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (660 aa)
IL17BInterleukin 17B. (180 aa)
IL1R2Interleukin 1 receptor type 2. (414 aa)
PLA2G3Phospholipase A2 group III. (510 aa)
IL17RAInterleukin 17 receptor A. (864 aa)
IL17RCInterleukin 17 receptor C. (713 aa)
M3YZK9_MUSPFCUE domain-containing protein. (287 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (672 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (576 aa)
PLA2G10Phospholipase A(2). (159 aa)
CD6CD6 molecule. (672 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1064 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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