STRINGSTRING
DLX5 DLX5 CARF CARF RELA RELA JUN JUN CHD6 CHD6 EP300 EP300 SESN2 SESN2 M3YRV1_MUSPF M3YRV1_MUSPF ATF2 ATF2 M3YQ14_MUSPF M3YQ14_MUSPF M3YPM9_MUSPF M3YPM9_MUSPF RUNX2 RUNX2 SMAD5 SMAD5 HIF1A HIF1A NOTCH1 NOTCH1 SMAD1 SMAD1 TP53 TP53 M3YEN4_MUSPF M3YEN4_MUSPF BMP2 BMP2 CREB3 CREB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DLX5Distal-less homeobox 5. (289 aa)
CARFCalcium responsive transcription factor. (723 aa)
RELARELA proto-oncogene, NF-kB subunit. (511 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
CHD6Chromodomain helicase DNA binding protein 6. (2724 aa)
EP300E1A binding protein p300. (2425 aa)
SESN2Sestrin 2. (479 aa)
M3YRV1_MUSPFUncharacterized protein. (286 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
M3YQ14_MUSPFBZIP domain-containing protein. (346 aa)
M3YPM9_MUSPFBZIP domain-containing protein. (351 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (507 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (824 aa)
NOTCH1Notch receptor 1. (2119 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
M3YEN4_MUSPFBZIP domain-containing protein. (358 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
CREB3cAMP responsive element binding protein 3. (353 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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