(27 nodes) Regulation of amyloid-beta formation network (Mustela putorius)

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second shell of interactors

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Known Interactions

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Predicted Interactions

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Your Input:
	RTN4	Reticulon. (986 aa)
	TMED10	Transmembrane p24 trafficking protein 10. (224 aa)
	RTN1	Reticulon. (720 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
	GSAP	Gamma-secretase activating protein. (782 aa)
	PRNP	Major prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...] (257 aa)
	M3Y830_MUSPF	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (417 aa)
	ABCG1	ATP binding cassette subfamily G member 1. (653 aa)
	ABCA7	ATP binding cassette subfamily A member 7. (2152 aa)
	SORL1	Sortilin related receptor 1. (2211 aa)
	RTN2	Reticulon. (476 aa)
	SP1	Sp1 transcription factor. (787 aa)
	SLC2A13	Solute carrier family 2 member 13; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (648 aa)
	NTRK2	Neurotrophic receptor tyrosine kinase 2. (477 aa)
	ROCK1	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1252 aa)
	EFNA1	Ephrin A1; Belongs to the ephrin family. (175 aa)
	EPHA4	EPH receptor A4. (986 aa)
	IFNGR1	Interferon gamma receptor 1. (474 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (162 aa)
	GGA3	Golgi associated, gamma adaptin ear containing, ARF binding protein 3. (731 aa)
	SPON1	Spondin 1. (807 aa)
	BIN1	Bridging integrator 1. (594 aa)
	IGF1	Insulin like growth factor 1. (153 aa)
	LRRTM3	Leucine rich repeat transmembrane neuronal 3. (581 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (511 aa)
	TNF	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (277 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA7	BIN1	ENSMPUP00000008944	ENSMPUP00000011941	ATP binding cassette subfamily A member 7.	Bridging integrator 1.	0.702
ABCA7	SORL1	ENSMPUP00000008944	ENSMPUP00000005716	ATP binding cassette subfamily A member 7.	Sortilin related receptor 1.	0.644
BIN1	ABCA7	ENSMPUP00000011941	ENSMPUP00000008944	Bridging integrator 1.	ATP binding cassette subfamily A member 7.	0.702
BIN1	SORL1	ENSMPUP00000011941	ENSMPUP00000005716	Bridging integrator 1.	Sortilin related receptor 1.	0.511
CASP3	IFNG	ENSMPUP00000010994	ENSMPUP00000017401	Caspase 3; Belongs to the peptidase C14A family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	0.647
CASP3	RELA	ENSMPUP00000010994	ENSMPUP00000011545	Caspase 3; Belongs to the peptidase C14A family.	RELA proto-oncogene, NF-kB subunit.	0.443
CASP3	ROCK1	ENSMPUP00000010994	ENSMPUP00000005447	Caspase 3; Belongs to the peptidase C14A family.	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.919
CASP3	TNF	ENSMPUP00000010994	ENSMPUP00000011297	Caspase 3; Belongs to the peptidase C14A family.	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	0.807
EFNA1	EPHA4	ENSMPUP00000005666	ENSMPUP00000016569	Ephrin A1; Belongs to the ephrin family.	EPH receptor A4.	0.990
EFNA1	NTRK2	ENSMPUP00000005666	ENSMPUP00000002158	Ephrin A1; Belongs to the ephrin family.	Neurotrophic receptor tyrosine kinase 2.	0.892
EPHA4	EFNA1	ENSMPUP00000016569	ENSMPUP00000005666	EPH receptor A4.	Ephrin A1; Belongs to the ephrin family.	0.990
GSAP	SPON1	ENSMPUP00000018165	ENSMPUP00000013064	Gamma-secretase activating protein.	Spondin 1.	0.401
GSAP	TMED10	ENSMPUP00000018165	ENSMPUP00000009082	Gamma-secretase activating protein.	Transmembrane p24 trafficking protein 10.	0.492
GSAP	TNF	ENSMPUP00000018165	ENSMPUP00000011297	Gamma-secretase activating protein.	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	0.412
IFNG	CASP3	ENSMPUP00000017401	ENSMPUP00000010994	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	Caspase 3; Belongs to the peptidase C14A family.	0.647
IFNG	IFNGR1	ENSMPUP00000017401	ENSMPUP00000014756	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	Interferon gamma receptor 1.	0.991
IFNG	RELA	ENSMPUP00000017401	ENSMPUP00000011545	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	RELA proto-oncogene, NF-kB subunit.	0.410
IFNG	TNF	ENSMPUP00000017401	ENSMPUP00000011297	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	0.868
IFNGR1	IFNG	ENSMPUP00000014756	ENSMPUP00000017401	Interferon gamma receptor 1.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	0.991
M3Y830_MUSPF	PRNP	ENSMPUP00000007487	ENSMPUP00000019010	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Major prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...]	0.495