node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BMP4 | IL6 | ENSMPUP00000005423 | ENSMPUP00000013489 | Bone morphogenetic protein 4. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.538 |
EGFR | IL6 | ENSMPUP00000018042 | ENSMPUP00000013489 | Receptor protein-tyrosine kinase. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.963 |
EGFR | TP53 | ENSMPUP00000018042 | ENSMPUP00000008945 | Receptor protein-tyrosine kinase. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.756 |
IL6 | BMP4 | ENSMPUP00000013489 | ENSMPUP00000005423 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | Bone morphogenetic protein 4. | 0.538 |
IL6 | EGFR | ENSMPUP00000013489 | ENSMPUP00000018042 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | Receptor protein-tyrosine kinase. | 0.963 |
IL6 | TP53 | ENSMPUP00000013489 | ENSMPUP00000008945 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.637 |
M3XVG1_MUSPF | TP53 | ENSMPUP00000003061 | ENSMPUP00000008945 | Helicase C-terminal domain-containing protein. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.501 |
M3XVG1_MUSPF | TRUB1 | ENSMPUP00000003061 | ENSMPUP00000003526 | Helicase C-terminal domain-containing protein. | TruB pseudouridine synthase family member 1. | 0.467 |
M3YCX9_MUSPF | TP53 | ENSMPUP00000009186 | ENSMPUP00000008945 | Uncharacterized protein; Belongs to the DEAD box helicase family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.501 |
M3YCX9_MUSPF | TRUB1 | ENSMPUP00000009186 | ENSMPUP00000003526 | Uncharacterized protein; Belongs to the DEAD box helicase family. | TruB pseudouridine synthase family member 1. | 0.467 |
M3YT25_MUSPF | TP53 | ENSMPUP00000014485 | ENSMPUP00000008945 | Uncharacterized protein; Belongs to the DEAD box helicase family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.501 |
M3YT25_MUSPF | TRUB1 | ENSMPUP00000014485 | ENSMPUP00000003526 | Uncharacterized protein; Belongs to the DEAD box helicase family. | TruB pseudouridine synthase family member 1. | 0.467 |
TP53 | EGFR | ENSMPUP00000008945 | ENSMPUP00000018042 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Receptor protein-tyrosine kinase. | 0.756 |
TP53 | IL6 | ENSMPUP00000008945 | ENSMPUP00000013489 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.637 |
TP53 | M3XVG1_MUSPF | ENSMPUP00000008945 | ENSMPUP00000003061 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Helicase C-terminal domain-containing protein. | 0.501 |
TP53 | M3YCX9_MUSPF | ENSMPUP00000008945 | ENSMPUP00000009186 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Uncharacterized protein; Belongs to the DEAD box helicase family. | 0.501 |
TP53 | M3YT25_MUSPF | ENSMPUP00000008945 | ENSMPUP00000014485 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Uncharacterized protein; Belongs to the DEAD box helicase family. | 0.501 |
TRUB1 | M3XVG1_MUSPF | ENSMPUP00000003526 | ENSMPUP00000003061 | TruB pseudouridine synthase family member 1. | Helicase C-terminal domain-containing protein. | 0.467 |
TRUB1 | M3YCX9_MUSPF | ENSMPUP00000003526 | ENSMPUP00000009186 | TruB pseudouridine synthase family member 1. | Uncharacterized protein; Belongs to the DEAD box helicase family. | 0.467 |
TRUB1 | M3YT25_MUSPF | ENSMPUP00000003526 | ENSMPUP00000014485 | TruB pseudouridine synthase family member 1. | Uncharacterized protein; Belongs to the DEAD box helicase family. | 0.467 |