STRINGSTRING
LRRK2 LRRK2 LRP2 LRP2 M3XP47_MUSPF M3XP47_MUSPF FZD3 FZD3 GLI1 GLI1 KDM2B KDM2B SHCBP1 SHCBP1 LHX5 LHX5 ZNF423 ZNF423 PTBP2 PTBP2 DRD2 DRD2 PTN PTN ADGRG1 ADGRG1 OTP OTP M3Y1J2_MUSPF M3Y1J2_MUSPF FOXG1 FOXG1 ILK ILK DISC1 DISC1 SMO SMO ITGB1 ITGB1 HIF1A HIF1A CDON CDON PTPRZ1 PTPRZ1 DMRTA2 DMRTA2 EMX1 EMX1 DLL4 DLL4 SMARCD3 SMARCD3 TP53 TP53 NR2E1 NR2E1 FOXO3 FOXO3 M3YF22_MUSPF M3YF22_MUSPF TOX TOX ELL3 ELL3 GPR37L1 GPR37L1 PAX6 PAX6 CTNNB1 CTNNB1 BTG2 BTG2 DCT DCT APPL2 APPL2 RAPGEF1 RAPGEF1 SOX10 SOX10 TRIM71 TRIM71 NF2 NF2 PROX1 PROX1 LHX2 LHX2 NF1 NF1 LHX1 LHX1 KIFAP3 KIFAP3 KDM1A KDM1A DISP3 DISP3 LIMS2 LIMS2 FGF2 FGF2 SMARCA1 SMARCA1 ZNF335 ZNF335 GLI3 GLI3 M3Z6K8_MUSPF M3Z6K8_MUSPF LOC106003358 LOC106003358
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LRRK2Leucine rich repeat kinase 2. (2527 aa)
LRP2LDL receptor related protein 2. (4699 aa)
M3XP47_MUSPFUncharacterized protein. (547 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
GLI1GLI family zinc finger 1. (1105 aa)
KDM2BLysine demethylase 2B. (1310 aa)
SHCBP1SHC binding and spindle associated 1. (732 aa)
LHX5LIM homeobox 5. (402 aa)
ZNF423Zinc finger protein 423. (1224 aa)
PTBP2Polypyrimidine tract binding protein 2. (532 aa)
DRD2D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. (443 aa)
PTNPleiotrophin. (168 aa)
ADGRG1Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (687 aa)
OTPOrthopedia homeobox. (325 aa)
M3Y1J2_MUSPFUncharacterized protein. (127 aa)
FOXG1Forkhead box G1. (424 aa)
ILKIntegrin linked kinase. (452 aa)
DISC1DISC1 scaffold protein. (865 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (790 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (824 aa)
CDONCell adhesion associated, oncogene regulated. (1260 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (2325 aa)
DMRTA2DMRT like family A2. (486 aa)
EMX1Empty spiracles homeobox 1. (207 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (441 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
FOXO3Forkhead box O3. (671 aa)
M3YF22_MUSPFUncharacterized protein. (473 aa)
TOXThymocyte selection associated high mobility group box. (526 aa)
ELL3Elongation factor for RNA polymerase II 3. (396 aa)
GPR37L1G protein-coupled receptor 37 like 1. (470 aa)
PAX6Paired box 6. (436 aa)
CTNNB1Catenin beta 1. (781 aa)
BTG2BTG anti-proliferation factor 2. (162 aa)
DCTDopachrome tautomerase. (517 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (660 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1265 aa)
SOX10SRY-box transcription factor 10. (602 aa)
TRIM71Tripartite motif containing 71. (514 aa)
NF2Neurofibromin 2. (591 aa)
PROX1Prospero homeobox 1. (737 aa)
LHX2LIM homeobox 2. (406 aa)
NF1Neurofibromin 1. (2815 aa)
LHX1LIM homeobox 1. (406 aa)
KIFAP3Kinesin associated protein 3. (793 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (874 aa)
DISP3Dispatched RND transporter family member 3. (1394 aa)
LIMS2LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (341 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
SMARCA1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (1132 aa)
ZNF335Zinc finger protein 335. (1341 aa)
GLI3GLI family zinc finger 3. (1585 aa)
M3Z6K8_MUSPFG_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor Fz/Smo family. (397 aa)
LOC106003358Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (544 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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