(37 nodes) Regulation of transcription regulatory region DNA binding network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ZBTB7C	Zinc finger and BTB domain containing 7C. (704 aa)
	GTF2B	General transcription factor IIB. (316 aa)
	PARK7	Parkinsonism associated deglycase. (189 aa)
	DOT1L	Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1643 aa)
	FBXW7	F-box and WD repeat domain containing 7. (708 aa)
	MAD2L2	Mitotic arrest deficient 2 like 2. (211 aa)
	GATA3	GATA binding protein 3. (444 aa)
	M3YSW1_MUSPF	BHLH domain-containing protein. (111 aa)
	HEYL	Hes related family bHLH transcription factor with YRPW motif like. (328 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	LHX2	LIM homeobox 2. (406 aa)
	NIBAN2	Niban apoptosis regulator 2. (733 aa)
	GATA1	GATA binding protein 1. (414 aa)
	HAND1	Heart and neural crest derivatives expressed 1. (215 aa)
	EP300	E1A binding protein p300. (2425 aa)
	SIN3A	SIN3 transcription regulator family member A. (1550 aa)
	RNF220	Ring finger protein 220. (592 aa)
	LIF	LIF interleukin 6 family cytokine. (202 aa)
	NSD1	Nuclear receptor binding SET domain protein 1. (2701 aa)
	IGF1	Insulin like growth factor 1. (153 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
	PAX6	Paired box 6. (436 aa)
	ANKRD33B	Ankyrin repeat domain 33B. (486 aa)
	ZC4H2	Zinc finger C4H2-type containing. (224 aa)
	ZBTB7A	Zinc finger and BTB domain containing 7A. (550 aa)
	FBXW9	F-box and WD repeat domain containing 9. (459 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (208 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
	DDRGK1	DDRGK domain containing 1. (315 aa)
	MSX1	Msh homeobox 1. (303 aa)
	HEY1	Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
	DDIT3	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
	RB1	RB transcriptional corepressor 1. (948 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
	TGFB1	Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
	SRI	Sorcin. (198 aa)
	ANKRD33	Ankyrin repeat domain 33. (370 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DOT1L	NSD1	ENSMPUP00000006907	ENSMPUP00000012178	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	Nuclear receptor binding SET domain protein 1.	0.686
EP300	GATA1	ENSMPUP00000016323	ENSMPUP00000013553	E1A binding protein p300.	GATA binding protein 1.	0.740
EP300	GATA3	ENSMPUP00000016323	ENSMPUP00000016298	E1A binding protein p300.	GATA binding protein 3.	0.939
EP300	GTF2B	ENSMPUP00000016323	ENSMPUP00000004760	E1A binding protein p300.	General transcription factor IIB.	0.567
EP300	NSD1	ENSMPUP00000016323	ENSMPUP00000012178	E1A binding protein p300.	Nuclear receptor binding SET domain protein 1.	0.464
EP300	PAX6	ENSMPUP00000016323	ENSMPUP00000011203	E1A binding protein p300.	Paired box 6.	0.525
EP300	SIN3A	ENSMPUP00000016323	ENSMPUP00000017213	E1A binding protein p300.	SIN3 transcription regulator family member A.	0.580
EP300	TGFB1	ENSMPUP00000016323	ENSMPUP00000017540	E1A binding protein p300.	Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...]	0.487
GATA1	EP300	ENSMPUP00000013553	ENSMPUP00000016323	GATA binding protein 1.	E1A binding protein p300.	0.740
GATA1	GATA3	ENSMPUP00000013553	ENSMPUP00000016298	GATA binding protein 1.	GATA binding protein 3.	0.403
GATA1	HAND2	ENSMPUP00000013553	ENSMPUP00000001892	GATA binding protein 1.	Heart and neural crest derivatives expressed 2.	0.597
GATA3	EP300	ENSMPUP00000016298	ENSMPUP00000016323	GATA binding protein 3.	E1A binding protein p300.	0.939
GATA3	GATA1	ENSMPUP00000016298	ENSMPUP00000013553	GATA binding protein 3.	GATA binding protein 1.	0.403
GATA3	HAND2	ENSMPUP00000016298	ENSMPUP00000001892	GATA binding protein 3.	Heart and neural crest derivatives expressed 2.	0.578
GATA3	IFNG	ENSMPUP00000016298	ENSMPUP00000017401	GATA binding protein 3.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	0.732
GATA3	LHX2	ENSMPUP00000016298	ENSMPUP00000013936	GATA binding protein 3.	LIM homeobox 2.	0.618
GTF2B	EP300	ENSMPUP00000004760	ENSMPUP00000016323	General transcription factor IIB.	E1A binding protein p300.	0.567
HAND2	GATA1	ENSMPUP00000001892	ENSMPUP00000013553	Heart and neural crest derivatives expressed 2.	GATA binding protein 1.	0.597
HAND2	GATA3	ENSMPUP00000001892	ENSMPUP00000016298	Heart and neural crest derivatives expressed 2.	GATA binding protein 3.	0.578
HEY1	HEYL	ENSMPUP00000001843	ENSMPUP00000014305	Hes related family bHLH transcription factor with YRPW motif 1.	Hes related family bHLH transcription factor with YRPW motif like.	0.835