(23 nodes) Regulation of double-strand break repair via nonhomologous end joining network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	POT1	Protection of telomeres 1. (785 aa)
	HSF1	Heat shock transcription factor 1. (555 aa)
	SMCHD1	Structural maintenance of chromosomes flexible hinge domain containing 1. (2007 aa)
	DEK	DEK proto-oncogene. (369 aa)
	PARP9	Poly [ADP-ribose] polymerase. (995 aa)
	DTX3L	Deltex E3 ubiquitin ligase 3L. (745 aa)
	KMT5B	Lysine methyltransferase 5B. (940 aa)
	CYREN	Cell cycle regulator of NHEJ. (155 aa)
	PNKP	Polynucleotide kinase 3'-phosphatase. (520 aa)
	PRKDC	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4110 aa)
	MRNIP	MRN complex interacting protein. (339 aa)
	RIF1	Replication timing regulatory factor 1. (2475 aa)
	M3Z1E7_MUSPF	Uncharacterized protein. (109 aa)
	MAD2L2	Mitotic arrest deficient 2 like 2. (211 aa)
	AUNIP	Aurora kinase A and ninein interacting protein. (353 aa)
	PARP3	Poly [ADP-ribose] polymerase. (531 aa)
	NSD2	Nuclear receptor binding SET domain protein 2. (1344 aa)
	ENSMPUP00000010584	annotation not available (61 aa)
	ERCC6	ERCC excision repair 6, chromatin remodeling factor. (1482 aa)
	WRAP53	WD repeat containing antisense to TP53. (539 aa)
	SHLD2	Shieldin complex subunit 2. (906 aa)
	M3YBF2_MUSPF	Uncharacterized protein. (61 aa)
	KMT5C	Lysine methyltransferase 5C. (459 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AUNIP	CYREN	ENSMPUP00000015666	ENSMPUP00000004203	Aurora kinase A and ninein interacting protein.	Cell cycle regulator of NHEJ.	0.483
CYREN	AUNIP	ENSMPUP00000004203	ENSMPUP00000015666	Cell cycle regulator of NHEJ.	Aurora kinase A and ninein interacting protein.	0.483
DEK	ERCC6	ENSMPUP00000004992	ENSMPUP00000009183	DEK proto-oncogene.	ERCC excision repair 6, chromatin remodeling factor.	0.688
DTX3L	PARP9	ENSMPUP00000004704	ENSMPUP00000004712	Deltex E3 ubiquitin ligase 3L.	Poly [ADP-ribose] polymerase.	0.996
ENSMPUP00000010584	ERCC6	ENSMPUP00000010584	ENSMPUP00000009183	annotation not available	ERCC excision repair 6, chromatin remodeling factor.	0.532
ERCC6	DEK	ENSMPUP00000009183	ENSMPUP00000004992	ERCC excision repair 6, chromatin remodeling factor.	DEK proto-oncogene.	0.688
ERCC6	ENSMPUP00000010584	ENSMPUP00000009183	ENSMPUP00000010584	ERCC excision repair 6, chromatin remodeling factor.	annotation not available	0.532
ERCC6	M3YBF2_MUSPF	ENSMPUP00000009183	ENSMPUP00000008659	ERCC excision repair 6, chromatin remodeling factor.	Uncharacterized protein.	0.532
KMT5B	NSD2	ENSMPUP00000004293	ENSMPUP00000010947	Lysine methyltransferase 5B.	Nuclear receptor binding SET domain protein 2.	0.501
M3YBF2_MUSPF	ERCC6	ENSMPUP00000008659	ENSMPUP00000009183	Uncharacterized protein.	ERCC excision repair 6, chromatin remodeling factor.	0.532
MAD2L2	RIF1	ENSMPUP00000016318	ENSMPUP00000000369	Mitotic arrest deficient 2 like 2.	Replication timing regulatory factor 1.	0.422
MAD2L2	SHLD2	ENSMPUP00000016318	ENSMPUP00000008876	Mitotic arrest deficient 2 like 2.	Shieldin complex subunit 2.	0.915
NSD2	KMT5B	ENSMPUP00000010947	ENSMPUP00000004293	Nuclear receptor binding SET domain protein 2.	Lysine methyltransferase 5B.	0.501
NSD2	PRKDC	ENSMPUP00000010947	ENSMPUP00000001012	Nuclear receptor binding SET domain protein 2.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.593
NSD2	RIF1	ENSMPUP00000010947	ENSMPUP00000000369	Nuclear receptor binding SET domain protein 2.	Replication timing regulatory factor 1.	0.501
PARP3	PARP9	ENSMPUP00000011685	ENSMPUP00000004712	Poly [ADP-ribose] polymerase.	Poly [ADP-ribose] polymerase.	0.601
PARP3	PNKP	ENSMPUP00000011685	ENSMPUP00000002289	Poly [ADP-ribose] polymerase.	Polynucleotide kinase 3'-phosphatase.	0.559
PARP3	PRKDC	ENSMPUP00000011685	ENSMPUP00000001012	Poly [ADP-ribose] polymerase.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.523
PARP9	DTX3L	ENSMPUP00000004712	ENSMPUP00000004704	Poly [ADP-ribose] polymerase.	Deltex E3 ubiquitin ligase 3L.	0.996
PARP9	PARP3	ENSMPUP00000004712	ENSMPUP00000011685	Poly [ADP-ribose] polymerase.	Poly [ADP-ribose] polymerase.	0.601