(23 nodes) Negative regulation of cation channel activity network (Mustela putorius)

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Predicted Interactions

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Your Input:
	KCNE3	Potassium voltage-gated channel subfamily E regulatory subunit 3. (99 aa)
	M3Z785_MUSPF	Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
	KCNE4	Potassium voltage-gated channel subfamily E regulatory subunit 4. (170 aa)
	CALM3	Calmodulin 3; Belongs to the calmodulin family. (151 aa)
	RRAD	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
	REM2	RRAD and GEM like GTPase 2. (342 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (915 aa)
	GNB5	G protein subunit beta 5. (301 aa)
	CALM1	Calmodulin 1; Belongs to the calmodulin family. (156 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
	GEM	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
	CALM2	Calmodulin 2; Belongs to the calmodulin family. (149 aa)
	FKBP1B	Peptidylprolyl isomerase. (209 aa)
	GRP	Gastrin releasing peptide. (147 aa)
	CRBN	Cereblon. (444 aa)
	REM1	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
	SRI	Sorcin. (198 aa)
	KCNE2	Potassium voltage-gated channel subfamily E regulatory subunit 2. (123 aa)
	M3Z6U8_MUSPF	Small ubiquitin-related modifier. (100 aa)
	CASQ2	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (505 aa)
	M3XQH2_MUSPF	Uncharacterized protein. (130 aa)
	DRD3	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (447 aa)
	CBARP	CACN subunit beta associated regulatory protein. (552 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALM1	CAV1	ENSMPUP00000008029	ENSMPUP00000007166	Calmodulin 1; Belongs to the calmodulin family.	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	0.798
CALM1	FKBP1B	ENSMPUP00000008029	ENSMPUP00000013836	Calmodulin 1; Belongs to the calmodulin family.	Peptidylprolyl isomerase.	0.879
CALM1	M3Z785_MUSPF	ENSMPUP00000008029	ENSMPUP00000019448	Calmodulin 1; Belongs to the calmodulin family.	Uncharacterized protein; Belongs to the calmodulin family.	0.701
CALM2	CASQ2	ENSMPUP00000011969	ENSMPUP00000001648	Calmodulin 2; Belongs to the calmodulin family.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.442
CALM2	CAV1	ENSMPUP00000011969	ENSMPUP00000007166	Calmodulin 2; Belongs to the calmodulin family.	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	0.798
CALM2	FKBP1B	ENSMPUP00000011969	ENSMPUP00000013836	Calmodulin 2; Belongs to the calmodulin family.	Peptidylprolyl isomerase.	0.879
CALM2	M3Z785_MUSPF	ENSMPUP00000011969	ENSMPUP00000019448	Calmodulin 2; Belongs to the calmodulin family.	Uncharacterized protein; Belongs to the calmodulin family.	0.701
CALM3	CAV1	ENSMPUP00000005223	ENSMPUP00000007166	Calmodulin 3; Belongs to the calmodulin family.	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	0.798
CALM3	FKBP1B	ENSMPUP00000005223	ENSMPUP00000013836	Calmodulin 3; Belongs to the calmodulin family.	Peptidylprolyl isomerase.	0.880
CALM3	KCNE3	ENSMPUP00000005223	ENSMPUP00000019405	Calmodulin 3; Belongs to the calmodulin family.	Potassium voltage-gated channel subfamily E regulatory subunit 3.	0.419
CALM3	M3Z785_MUSPF	ENSMPUP00000005223	ENSMPUP00000019448	Calmodulin 3; Belongs to the calmodulin family.	Uncharacterized protein; Belongs to the calmodulin family.	0.701
CASQ2	CALM2	ENSMPUP00000001648	ENSMPUP00000011969	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Calmodulin 2; Belongs to the calmodulin family.	0.442
CASQ2	FKBP1B	ENSMPUP00000001648	ENSMPUP00000013836	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Peptidylprolyl isomerase.	0.503
CASQ2	SRI	ENSMPUP00000001648	ENSMPUP00000018195	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Sorcin.	0.616
CAV1	CALM1	ENSMPUP00000007166	ENSMPUP00000008029	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Calmodulin 1; Belongs to the calmodulin family.	0.798
CAV1	CALM2	ENSMPUP00000007166	ENSMPUP00000011969	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Calmodulin 2; Belongs to the calmodulin family.	0.798
CAV1	CALM3	ENSMPUP00000007166	ENSMPUP00000005223	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Calmodulin 3; Belongs to the calmodulin family.	0.798
CAV1	M3Z785_MUSPF	ENSMPUP00000007166	ENSMPUP00000019448	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Uncharacterized protein; Belongs to the calmodulin family.	0.798
CAV1	SRI	ENSMPUP00000007166	ENSMPUP00000018195	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Sorcin.	0.519
DRD3	GNB5	ENSMPUP00000000275	ENSMPUP00000007579	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	G protein subunit beta 5.	0.947