(68 nodes) Recycling endosome network (Mustela putorius)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RAB17	RAB17, member RAS oncogene family. (225 aa)
	RAB11A	RAB11A, member RAS oncogene family. (216 aa)
	GPR161	G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (529 aa)
	RAB8B	RAB8B, member RAS oncogene family. (207 aa)
	ABCB11	ATP binding cassette subfamily B member 11. (1325 aa)
	NDRG1	N-myc downstream regulated 1. (384 aa)
	RAP2C	RAP2C, member of RAS oncogene family. (183 aa)
	VPS52	VPS52 subunit of GARP complex. (723 aa)
	ATP11B	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1210 aa)
	MLC1	Modulator of VRAC current 1. (373 aa)
	CLCN4	Chloride channel protein. (760 aa)
	TPCN1	Two pore segment channel 1. (861 aa)
	KCNK1	Potassium two pore domain channel subfamily K member 1; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (233 aa)
	ATP13A5	Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1218 aa)
	ATP13A4	Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1233 aa)
	LZTR1	Leucine zipper like transcription regulator 1. (840 aa)
	ATP13A3	Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1228 aa)
	EHD2	EH domain containing 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (543 aa)
	CD274	CD274 molecule. (303 aa)
	EHD3	EH domain containing 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (476 aa)
	SCAMP1	Secretory carrier-associated membrane protein. (338 aa)
	SYT11	Synaptotagmin 11. (431 aa)
	NEU2	Neuraminidase 2. (379 aa)
	AVL9	AVL9 cell migration associated. (648 aa)
	TPP1	Tripeptidyl peptidase 1. (572 aa)
	SORL1	Sortilin related receptor 1. (2211 aa)
	CFTR	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1484 aa)
	RAB11B	RAB11B, member RAS oncogene family. (218 aa)
	ABHD17A	Abhydrolase domain containing 17A. (314 aa)
	M3Y866_MUSPF	Uncharacterized protein. (1308 aa)
	STX8	Syntaxin 8. (204 aa)
	M3Y931_MUSPF	Uncharacterized protein. (203 aa)
	NSG1	Neuronal vesicle trafficking associated 1. (186 aa)
	VPS50	VPS50 subunit of EARP/GARPII complex. (963 aa)
	VIPAS39	VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog. (493 aa)
	ABHD17B	Abhydrolase domain containing 17B. (296 aa)
	M3YD19_MUSPF	Uncharacterized protein. (829 aa)
	EHD4	EH domain containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (541 aa)
	M3YEI0_MUSPF	Gal_mutarotas_2 domain-containing protein; Belongs to the glycosyl hydrolase 31 family. (876 aa)
	TBC1D14	TBC1 domain family member 14. (693 aa)
	ATP11A	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1274 aa)
	RAP2A	RAP2A, member of RAS oncogene family. (138 aa)
	SLC9A9	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (644 aa)
	CMTM6	CKLF like MARVEL transmembrane domain containing 6. (183 aa)
	VPS51	VPS51 subunit of GARP complex. (792 aa)
	RAB4A	RAB4A, member RAS oncogene family. (215 aa)
	EHD1	EH domain containing 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (534 aa)
	CLN3	Battenin. (438 aa)
	SLC9A7	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (717 aa)
	MICALL1	MICAL like 1. (806 aa)
	SLC36A2	Solute carrier family 36 member 2. (483 aa)
	GRIPAP1	GRIP1 associated protein 1. (841 aa)
	ABHD17C	Abhydrolase domain containing 17C. (240 aa)
	STX12	Syntaxin 12; Belongs to the syntaxin family. (274 aa)
	BAIAP3	BAI1 associated protein 3. (1157 aa)
	RAB11FIP3	RAB11 family interacting protein 3. (647 aa)
	RAB8A	RAB8A, member RAS oncogene family. (207 aa)
	PACSIN2	Protein kinase C and casein kinase substrate in neurons 2. (486 aa)
	RELCH	RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1214 aa)
	DENND6A	DENN domain containing 6A. (525 aa)
	ZFYVE27	Zinc finger FYVE-type containing 27. (440 aa)
	M3Z0B3_MUSPF	Rab-GAP TBC domain-containing protein. (352 aa)
	SCAMP2	Secretory carrier-associated membrane protein. (329 aa)
	ARFGEF2	ADP ribosylation factor guanine nucleotide exchange factor 2. (1785 aa)
	WASHC1	WASH complex subunit 1. (472 aa)
	RAP2B	RAP2B, member of RAS oncogene family. (183 aa)
	M3Z630_MUSPF	Uncharacterized protein. (200 aa)
	ARF6	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARF6	ARFGEF2	ENSMPUP00000019499	ENSMPUP00000017476	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	ADP ribosylation factor guanine nucleotide exchange factor 2.	0.400
ARF6	RAB11A	ENSMPUP00000019499	ENSMPUP00000000385	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	RAB11A, member RAS oncogene family.	0.407
ARF6	RAB11B	ENSMPUP00000019499	ENSMPUP00000007206	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	RAB11B, member RAS oncogene family.	0.407
ARF6	RAB11FIP3	ENSMPUP00000019499	ENSMPUP00000015900	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	RAB11 family interacting protein 3.	0.829
ARF6	RAB4A	ENSMPUP00000019499	ENSMPUP00000012253	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	RAB4A, member RAS oncogene family.	0.420
ARFGEF2	ARF6	ENSMPUP00000017476	ENSMPUP00000019499	ADP ribosylation factor guanine nucleotide exchange factor 2.	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	0.400
ATP11A	ATP11B	ENSMPUP00000010381	ENSMPUP00000002334	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	0.581
ATP11B	ATP11A	ENSMPUP00000002334	ENSMPUP00000010381	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	0.581
ATP13A4	TPCN1	ENSMPUP00000003566	ENSMPUP00000002578	Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.	Two pore segment channel 1.	0.497
ATP13A5	TPCN1	ENSMPUP00000003549	ENSMPUP00000002578	Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.	Two pore segment channel 1.	0.497
AVL9	RAB17	ENSMPUP00000005427	ENSMPUP00000000075	AVL9 cell migration associated.	RAB17, member RAS oncogene family.	0.420
CD274	CMTM6	ENSMPUP00000004915	ENSMPUP00000011812	CD274 molecule.	CKLF like MARVEL transmembrane domain containing 6.	0.541
CFTR	CLCN4	ENSMPUP00000007081	ENSMPUP00000002466	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	Chloride channel protein.	0.428
CFTR	SYT11	ENSMPUP00000007081	ENSMPUP00000005230	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	Synaptotagmin 11.	0.412
CLCN4	CFTR	ENSMPUP00000002466	ENSMPUP00000007081	Chloride channel protein.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	0.428
CLN3	TPP1	ENSMPUP00000012633	ENSMPUP00000005439	Battenin.	Tripeptidyl peptidase 1.	0.740
CMTM6	CD274	ENSMPUP00000011812	ENSMPUP00000004915	CKLF like MARVEL transmembrane domain containing 6.	CD274 molecule.	0.541
EHD1	M3Y866_MUSPF	ENSMPUP00000012403	ENSMPUP00000007523	EH domain containing 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Uncharacterized protein.	0.844
EHD1	MICALL1	ENSMPUP00000012403	ENSMPUP00000012876	EH domain containing 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	MICAL like 1.	0.987
EHD2	MICALL1	ENSMPUP00000004432	ENSMPUP00000012876	EH domain containing 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	MICAL like 1.	0.595