(24 nodes) Toll/interleukin-1 receptor homology (TIR) domain network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1083 aa)
	TLR8	Toll like receptor 8; Belongs to the Toll-like receptor family. (1087 aa)
	IL1RAPL1	Interleukin 1 receptor accessory protein like 1. (413 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	IL1RAP	Interleukin 1 receptor accessory protein. (568 aa)
	TICAM1	TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (689 aa)
	M3Y1R3_MUSPF	TIR domain-containing protein. (217 aa)
	TIRAP	TIR domain containing adaptor protein. (227 aa)
	SIGIRR	Single Ig and TIR domain containing. (410 aa)
	BANK1	B cell scaffold protein with ankyrin repeats 1. (783 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (764 aa)
	M3YJV8_MUSPF	Uncharacterized protein. (1327 aa)
	IL1R1	Interleukin 1 receptor type 1. (573 aa)
	IL1RL2	Interleukin 1 receptor like 2. (680 aa)
	IL1RL1	Interleukin 1 receptor like 1. (556 aa)
	IL18R1	Interleukin 18 receptor 1. (539 aa)
	IL18RAP	Interleukin 18 receptor accessory protein. (581 aa)
	SARM1	Sterile alpha and TIR motif containing 1. (724 aa)
	PIK3AP1	Phosphoinositide-3-kinase adaptor protein 1. (764 aa)
	TLR5	Toll like receptor 5; Belongs to the Toll-like receptor family. (858 aa)
	TLR2	Toll like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
	TLR1	Toll like receptor 1; Belongs to the Toll-like receptor family. (786 aa)
	TLR6	Toll like receptor 6; Belongs to the Toll-like receptor family. (793 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL18R1	IL18RAP	ENSMPUP00000012167	ENSMPUP00000012171	Interleukin 18 receptor 1.	Interleukin 18 receptor accessory protein.	0.995
IL18R1	IL1R1	ENSMPUP00000012167	ENSMPUP00000012143	Interleukin 18 receptor 1.	Interleukin 1 receptor type 1.	0.522
IL18R1	IL1RAP	ENSMPUP00000012167	ENSMPUP00000003452	Interleukin 18 receptor 1.	Interleukin 1 receptor accessory protein.	0.463
IL18R1	SIGIRR	ENSMPUP00000012167	ENSMPUP00000008548	Interleukin 18 receptor 1.	Single Ig and TIR domain containing.	0.580
IL18RAP	IL18R1	ENSMPUP00000012171	ENSMPUP00000012167	Interleukin 18 receptor accessory protein.	Interleukin 18 receptor 1.	0.995
IL18RAP	IL1RAP	ENSMPUP00000012171	ENSMPUP00000003452	Interleukin 18 receptor accessory protein.	Interleukin 1 receptor accessory protein.	0.664
IL18RAP	MYD88	ENSMPUP00000012171	ENSMPUP00000002726	Interleukin 18 receptor accessory protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.666
IL1R1	IL18R1	ENSMPUP00000012143	ENSMPUP00000012167	Interleukin 1 receptor type 1.	Interleukin 18 receptor 1.	0.522
IL1R1	IL1RAP	ENSMPUP00000012143	ENSMPUP00000003452	Interleukin 1 receptor type 1.	Interleukin 1 receptor accessory protein.	0.969
IL1R1	IL1RL1	ENSMPUP00000012143	ENSMPUP00000012163	Interleukin 1 receptor type 1.	Interleukin 1 receptor like 1.	0.551
IL1R1	MYD88	ENSMPUP00000012143	ENSMPUP00000002726	Interleukin 1 receptor type 1.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.985
IL1RAP	IL18R1	ENSMPUP00000003452	ENSMPUP00000012167	Interleukin 1 receptor accessory protein.	Interleukin 18 receptor 1.	0.463
IL1RAP	IL18RAP	ENSMPUP00000003452	ENSMPUP00000012171	Interleukin 1 receptor accessory protein.	Interleukin 18 receptor accessory protein.	0.664
IL1RAP	IL1R1	ENSMPUP00000003452	ENSMPUP00000012143	Interleukin 1 receptor accessory protein.	Interleukin 1 receptor type 1.	0.969
IL1RAP	IL1RL1	ENSMPUP00000003452	ENSMPUP00000012163	Interleukin 1 receptor accessory protein.	Interleukin 1 receptor like 1.	0.985
IL1RAP	IL1RL2	ENSMPUP00000003452	ENSMPUP00000012149	Interleukin 1 receptor accessory protein.	Interleukin 1 receptor like 2.	0.964
IL1RAP	MYD88	ENSMPUP00000003452	ENSMPUP00000002726	Interleukin 1 receptor accessory protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.906
IL1RL1	IL1R1	ENSMPUP00000012163	ENSMPUP00000012143	Interleukin 1 receptor like 1.	Interleukin 1 receptor type 1.	0.551
IL1RL1	IL1RAP	ENSMPUP00000012163	ENSMPUP00000003452	Interleukin 1 receptor like 1.	Interleukin 1 receptor accessory protein.	0.985
IL1RL1	IL1RL2	ENSMPUP00000012163	ENSMPUP00000012149	Interleukin 1 receptor like 1.	Interleukin 1 receptor like 2.	0.561