(27 nodes) Translesion Synthesis by POLH network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RCBTB2	RCC1 and BTB domain containing protein 2. (551 aa)
	VCP	Valosin containing protein; Belongs to the AAA ATPase family. (806 aa)
	M3XQS3_MUSPF	Uncharacterized protein. (272 aa)
	RFC3	Replication factor C subunit 3. (356 aa)
	RFC5	Replication factor C subunit 5. (340 aa)
	SPRTN	SprT-like N-terminal domain. (487 aa)
	RFC1	Replication factor C subunit 1. (1155 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	RFC4	Replication factor C subunit 4. (360 aa)
	UFD1	Ubiquitin recognition factor in ER associated degradation 1. (307 aa)
	RPA2	Replication protein A2. (270 aa)
	SPATA5L1	Spermatogenesis associated 5 like 1. (769 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (156 aa)
	M3YFD0_MUSPF	Uncharacterized protein. (260 aa)
	M3YCE7_MUSPF	Uncharacterized protein. (124 aa)
	MEIOB	Meiosis specific with OB-fold. (471 aa)
	RFC2	Replication factor C subunit 2. (352 aa)
	SPATA5	Spermatogenesis associated 5. (893 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (531 aa)
	LOC101686900	Ubiquitin-like domain-containing protein. (127 aa)
	KXD1	KxDL motif containing 1. (182 aa)
	UBA52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	ATAD5	ATPase family AAA domain containing 5. (1892 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	POLH	DNA polymerase eta. (649 aa)
	M3YMN0_MUSPF	Ubiquitin-like domain-containing protein. (124 aa)
	NPLOC4	NPL4 homolog, ubiquitin recognition factor. (607 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	M3XQS3_MUSPF	ENSMPUP00000014578	ENSMPUP00000001423	ATPase family AAA domain containing 5.	Uncharacterized protein.	0.567
ATAD5	MEIOB	ENSMPUP00000014578	ENSMPUP00000015459	ATPase family AAA domain containing 5.	Meiosis specific with OB-fold.	0.683
ATAD5	PCNA	ENSMPUP00000014578	ENSMPUP00000006142	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.957
ATAD5	POLH	ENSMPUP00000014578	ENSMPUP00000012801	ATPase family AAA domain containing 5.	DNA polymerase eta.	0.591
ATAD5	RFC1	ENSMPUP00000014578	ENSMPUP00000005982	ATPase family AAA domain containing 5.	Replication factor C subunit 1.	0.650
ATAD5	RFC2	ENSMPUP00000014578	ENSMPUP00000016010	ATPase family AAA domain containing 5.	Replication factor C subunit 2.	0.975
ATAD5	RFC3	ENSMPUP00000014578	ENSMPUP00000001870	ATPase family AAA domain containing 5.	Replication factor C subunit 3.	0.968
ATAD5	RFC4	ENSMPUP00000014578	ENSMPUP00000003304	ATPase family AAA domain containing 5.	Replication factor C subunit 4.	0.989
ATAD5	RFC5	ENSMPUP00000014578	ENSMPUP00000002812	ATPase family AAA domain containing 5.	Replication factor C subunit 5.	0.961
ATAD5	RPA1	ENSMPUP00000014578	ENSMPUP00000013022	ATPase family AAA domain containing 5.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.683
ATAD5	RPA2	ENSMPUP00000014578	ENSMPUP00000015452	ATPase family AAA domain containing 5.	Replication protein A2.	0.521
ATAD5	RPS27A	ENSMPUP00000014578	ENSMPUP00000010391	ATPase family AAA domain containing 5.	Ubiquitin-like domain-containing protein.	0.548
ATAD5	SPATA5	ENSMPUP00000014578	ENSMPUP00000017275	ATPase family AAA domain containing 5.	Spermatogenesis associated 5.	0.429
ATAD5	SPATA5L1	ENSMPUP00000014578	ENSMPUP00000011060	ATPase family AAA domain containing 5.	Spermatogenesis associated 5 like 1.	0.429
ATAD5	SPRTN	ENSMPUP00000014578	ENSMPUP00000005466	ATPase family AAA domain containing 5.	SprT-like N-terminal domain.	0.648
ATAD5	UFD1	ENSMPUP00000014578	ENSMPUP00000003842	ATPase family AAA domain containing 5.	Ubiquitin recognition factor in ER associated degradation 1.	0.568
ATAD5	VCP	ENSMPUP00000014578	ENSMPUP00000004552	ATPase family AAA domain containing 5.	Valosin containing protein; Belongs to the AAA ATPase family.	0.429
KXD1	LOC101686900	ENSMPUP00000015426	ENSMPUP00000018679	KxDL motif containing 1.	Ubiquitin-like domain-containing protein.	0.898
KXD1	M3YFD0_MUSPF	ENSMPUP00000015426	ENSMPUP00000010037	KxDL motif containing 1.	Uncharacterized protein.	0.748
KXD1	M3YMN0_MUSPF	ENSMPUP00000015426	ENSMPUP00000012587	KxDL motif containing 1.	Ubiquitin-like domain-containing protein.	0.822