(49 nodes) PLC beta mediated events network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	M3XPU3_MUSPF	Uncharacterized protein; Belongs to the protein kinase superfamily. (361 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
	DCLK1	Doublecortin like kinase 1. (751 aa)
	NBEA	Neurobeachin. (2923 aa)
	PDE1A	Phosphodiesterase 1A; Belongs to the cyclic nucleotide phosphodiesterase family. (523 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	MAPK1	Mitogen-activated protein kinase. (333 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
	GNA11	G protein subunit alpha 11. (334 aa)
	THAP7	THAP domain containing 7. (313 aa)
	GRK2	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (647 aa)
	GNA15	G protein subunit alpha 15. (374 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1018 aa)
	CALM3	Calmodulin 3; Belongs to the calmodulin family. (151 aa)
	PDE1C	Phosphodiesterase. (709 aa)
	M3Y245_MUSPF	Uncharacterized protein. (127 aa)
	PDE1B	Phosphodiesterase. (535 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1105 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1096 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
	LRBA	LPS responsive beige-like anchor protein. (2856 aa)
	ADCY2	Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (880 aa)
	CALM1	Calmodulin 1; Belongs to the calmodulin family. (156 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1187 aa)
	THAP6	THAP domain containing 6. (222 aa)
	PRKCG	Non-specific serine/threonine protein kinase. (569 aa)
	PLA2G4A	Phospholipase A2. (749 aa)
	CALM2	Calmodulin 2; Belongs to the calmodulin family. (149 aa)
	CAMKK1	Calcium/calmodulin dependent protein kinase kinase 1. (505 aa)
	GNA14	G protein subunit alpha 14. (355 aa)
	GNAQ	G protein subunit alpha q. (301 aa)
	M3YMK1_MUSPF	Protein kinase domain-containing protein. (105 aa)
	M3YMK5_MUSPF	Protein kinase domain-containing protein. (185 aa)
	THAP1	THAP domain containing 1. (230 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
	PTRHD1	Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
	PRKAR2A	Protein kinase cAMP-dependent type II regulatory subunit alpha. (305 aa)
	PRKAR1A	Protein kinase cAMP-dependent type I regulatory subunit alpha. (422 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
	PRKCD	Protein kinase C. (730 aa)
	CNBD2	Cyclic nucleotide binding domain containing 2. (583 aa)
	PRKAR1B	Protein kinase cAMP-dependent type I regulatory subunit beta. (415 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1130 aa)
	PRKAR2B	Protein kinase cAMP-dependent type II regulatory subunit beta. (439 aa)
	M3Z785_MUSPF	Uncharacterized protein; Belongs to the calmodulin family. (149 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSMPUP00000018070	ENSMPUP00000007102	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.572
ADCY1	ADCY3	ENSMPUP00000018070	ENSMPUP00000013920	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.833
ADCY1	ADCY4	ENSMPUP00000018070	ENSMPUP00000005626	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.564
ADCY1	ADCY5	ENSMPUP00000018070	ENSMPUP00000004470	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.548
ADCY1	ADCY6	ENSMPUP00000018070	ENSMPUP00000014639	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.550
ADCY1	ADCY7	ENSMPUP00000018070	ENSMPUP00000003122	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.655
ADCY1	ADCY8	ENSMPUP00000018070	ENSMPUP00000001384	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.855
ADCY1	ADCY9	ENSMPUP00000018070	ENSMPUP00000014921	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.620
ADCY1	CALM1	ENSMPUP00000018070	ENSMPUP00000008029	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 1; Belongs to the calmodulin family.	0.756
ADCY1	CALM2	ENSMPUP00000018070	ENSMPUP00000011969	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 2; Belongs to the calmodulin family.	0.756
ADCY1	CALM3	ENSMPUP00000018070	ENSMPUP00000005223	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 3; Belongs to the calmodulin family.	0.756
ADCY1	M3YMK1_MUSPF	ENSMPUP00000018070	ENSMPUP00000012558	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein.	0.836
ADCY1	M3YMK5_MUSPF	ENSMPUP00000018070	ENSMPUP00000012562	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein.	0.836
ADCY1	M3Z785_MUSPF	ENSMPUP00000018070	ENSMPUP00000019448	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the calmodulin family.	0.825
ADCY1	PDE1A	ENSMPUP00000018070	ENSMPUP00000002207	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase 1A; Belongs to the cyclic nucleotide phosphodiesterase family.	0.865
ADCY1	PDE1B	ENSMPUP00000018070	ENSMPUP00000005578	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.857
ADCY1	PDE1C	ENSMPUP00000018070	ENSMPUP00000005383	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.858
ADCY1	PRKACA	ENSMPUP00000018070	ENSMPUP00000003045	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.878
ADCY1	PRKACB	ENSMPUP00000018070	ENSMPUP00000005718	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.882
ADCY1	PRKCA	ENSMPUP00000018070	ENSMPUP00000014555	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.856