STRINGSTRING
AGER AGER PPP2CA PPP2CA LY96 LY96 PPP2CB PPP2CB RPS27A RPS27A NKIRAS2 NKIRAS2 TNIP2 TNIP2 RIPK2 RIPK2 TRAF2 TRAF2 LRRC45 LRRC45 DUSP4 DUSP4 M3YJ23_MUSPF M3YJ23_MUSPF M3YJ45_MUSPF M3YJ45_MUSPF RELA RELA M3YJV8_MUSPF M3YJV8_MUSPF DUSP7 DUSP7 TRAF6 TRAF6 NKIRAS1 NKIRAS1 MAPK3 MAPK3 M3YMN0_MUSPF M3YMN0_MUSPF IKBKB IKBKB RPS6KA4 RPS6KA4 MAPKAPK3 MAPKAPK3 PPP2R5D PPP2R5D TAB1 TAB1 ELK1 ELK1 M3YQK9_MUSPF M3YQK9_MUSPF M3YQL2_MUSPF M3YQL2_MUSPF ATF2 ATF2 MAP2K6 MAP2K6 M3YUJ9_MUSPF M3YUJ9_MUSPF UBA52 UBA52 KXD1 KXD1 RPS6KA1 RPS6KA1 NFKBIA NFKBIA RELCH RELCH NFKB2 NFKB2 CHUK CHUK LRRC34 LRRC34 M3Z078_MUSPF M3Z078_MUSPF IRAK2 IRAK2 RBSN RBSN PPP2R1A PPP2R1A UBE2V1 UBE2V1 NFKBIB NFKBIB FOSL2 FOSL2 TAB2 TAB2 M3Z344_MUSPF M3Z344_MUSPF VWC2 VWC2 ENSMPUP00000018236 ENSMPUP00000018236 LOC101686900 LOC101686900 TIFA TIFA M3Z7R0_MUSPF M3Z7R0_MUSPF JUN JUN MAP2K3 MAP2K3 MAPK7 MAPK7 M3XM17_MUSPF M3XM17_MUSPF CASP8 CASP8 CREB1 CREB1 MAPK9 MAPK9 M3XP56_MUSPF M3XP56_MUSPF M3XP59_MUSPF M3XP59_MUSPF APP APP PIK3C3 PIK3C3 S100B S100B LOC101681938 LOC101681938 MAPK11 MAPK11 VRK3 VRK3 MAPK10 MAPK10 TAB3 TAB3 M3XV19_MUSPF M3XV19_MUSPF N4BP1 N4BP1 PELI3 PELI3 MAPK1 MAPK1 NOD2 NOD2 PPP4R4 PPP4R4 RPS6KA3 RPS6KA3 PPP2R1B PPP2R1B LRRC71 LRRC71 MAP2K4 MAP2K4 LRRC74B LRRC74B FNBP4 FNBP4 MAPK14 MAPK14 NLRC5 NLRC5 M3XZP3_MUSPF M3XZP3_MUSPF PPP4R1 PPP4R1 CREB5 CREB5 ECSIT ECSIT NOD1 NOD1 TICAM1 TICAM1 ATF1 ATF1 NLRX1 NLRX1 USP14 USP14 KHNYN KHNYN PELI2 PELI2 M3Y3I1_MUSPF M3Y3I1_MUSPF M3Y3L0_MUSPF M3Y3L0_MUSPF PELI1 PELI1 LRRC14 LRRC14 TONSL TONSL RPS6KA2 RPS6KA2 M3Y5Q1_MUSPF M3Y5Q1_MUSPF NLRP13 NLRP13 M3Y7T9_MUSPF M3Y7T9_MUSPF MAP3K1 MAP3K1 EEA1 EEA1 DUSP6 DUSP6 LOC101682402 LOC101682402 MAP2K7 MAP2K7 RPS6KA5 RPS6KA5 MAPK15 MAPK15 S100A12 S100A12 NLRP6 NLRP6 CD14 CD14 ALPK1 ALPK1 IRF7 IRF7 LRRC74A LRRC74A IRAK1 IRAK1 MAP3K7 MAP3K7 MAPK8 MAPK8 FOS FOS NFKB1 NFKB1 M3YE25_MUSPF M3YE25_MUSPF IKBKG IKBKG MAPKAPK2 MAPKAPK2 M3YFD0_MUSPF M3YFD0_MUSPF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGERAdvanced glycosylation end-product specific receptor. (400 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
LY96Lymphocyte antigen 96. (160 aa)
PPP2CBSerine/threonine-protein phosphatase. (284 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
NKIRAS2NFKB inhibitor interacting Ras like 2. (191 aa)
TNIP2TNFAIP3 interacting protein 2. (435 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
LRRC45Leucine rich repeat containing 45. (670 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (396 aa)
M3YJ23_MUSPFUBIQUITIN_CONJUGAT_2 domain-containing protein. (150 aa)
M3YJ45_MUSPFUncharacterized protein. (349 aa)
RELARELA proto-oncogene, NF-kB subunit. (511 aa)
M3YJV8_MUSPFUncharacterized protein. (1327 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (368 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (192 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
M3YMN0_MUSPFUbiquitin-like domain-containing protein. (124 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
RPS6KA4Ribosomal protein S6 kinase. (772 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (676 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
ELK1ETS transcription factor ELK1. (435 aa)
M3YQK9_MUSPFSerum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (134 aa)
M3YQL2_MUSPFSerum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (130 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
M3YUJ9_MUSPFHMG box domain-containing protein. (171 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
KXD1KxDL motif containing 1. (182 aa)
RPS6KA1Ribosomal protein S6 kinase. (719 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1214 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
LRRC34Leucine rich repeat containing 34. (496 aa)
M3Z078_MUSPFUncharacterized protein. (210 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (580 aa)
RBSNRabenosyn, RAB effector. (783 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (590 aa)
UBE2V1UBIQUITIN_CONJUGAT_2 domain-containing protein. (147 aa)
NFKBIBNFKB inhibitor beta. (354 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (287 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
M3Z344_MUSPFUSP domain-containing protein; Belongs to the peptidase C19 family. (373 aa)
VWC2Von Willebrand factor C domain containing 2. (275 aa)
ENSMPUP00000018236annotation not available (152 aa)
LOC101686900Ubiquitin-like domain-containing protein. (127 aa)
TIFATRAF interacting protein with forkhead associated domain. (186 aa)
M3Z7R0_MUSPFUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (149 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
MAP2K3Mitogen-activated protein kinase kinase 3. (396 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
M3XM17_MUSPFUncharacterized protein. (208 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (484 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
MAPK9Mitogen-activated protein kinase. (398 aa)
M3XP56_MUSPFProtein kinase domain-containing protein. (158 aa)
M3XP59_MUSPFSAM domain-containing protein. (355 aa)
APPAmyloid beta precursor protein. (630 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
LOC101681938Protein kinase domain-containing protein. (490 aa)
MAPK11Mitogen-activated protein kinase. (434 aa)
VRK3VRK serine/threonine kinase 3. (455 aa)
MAPK10Mitogen-activated protein kinase. (384 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (715 aa)
M3XV19_MUSPFUncharacterized protein. (123 aa)
N4BP1NEDD4 binding protein 1. (810 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (445 aa)
MAPK1Mitogen-activated protein kinase. (333 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1013 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (863 aa)
RPS6KA3Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (741 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (789 aa)
LRRC71Leucine rich repeat containing 71. (535 aa)
MAP2K4Mitogen-activated protein kinase kinase 4. (281 aa)
LRRC74BLeucine rich repeat containing 74B. (392 aa)
FNBP4Formin binding protein 4. (1028 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
NLRC5NLR family CARD domain containing 5. (1868 aa)
M3XZP3_MUSPFHMG box domain-containing protein. (215 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (906 aa)
CREB5cAMP responsive element binding protein 5. (275 aa)
ECSITECSIT signalling integrator. (436 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (952 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (689 aa)
ATF1Activating transcription factor 1. (289 aa)
NLRX1NLR family member X1. (975 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (494 aa)
KHNYNKH and NYN domain containing. (674 aa)
PELI2E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (426 aa)
M3Y3I1_MUSPFCyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (488 aa)
M3Y3L0_MUSPFUncharacterized protein. (99 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
LRRC14Leucine rich repeat containing 14. (493 aa)
TONSLTonsoku like, DNA repair protein. (1212 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
M3Y5Q1_MUSPFWRNPLPNID domain-containing protein. (921 aa)
NLRP13NLR family pyrin domain containing 13. (961 aa)
M3Y7T9_MUSPFUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1343 aa)
EEA1Early endosome antigen 1. (1364 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
LOC101682402Ubiquitin-conjugating enzyme E2N; Belongs to the ubiquitin-conjugating enzyme family. (163 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (461 aa)
RPS6KA5Ribosomal protein S6 kinase. (821 aa)
MAPK15Mitogen-activated protein kinase. (550 aa)
S100A12S100 calcium binding protein A12; Belongs to the S-100 family. (92 aa)
NLRP6NLR family pyrin domain containing 6. (948 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (371 aa)
ALPK1Alpha kinase 1. (1151 aa)
IRF7Interferon regulatory factor 7. (473 aa)
LRRC74ALeucine rich repeat containing 74A. (481 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (696 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
MAPK8Mitogen-activated protein kinase. (397 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (446 aa)
NFKB1Nuclear factor kappa B subunit 1. (971 aa)
M3YE25_MUSPFDual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (153 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (412 aa)
MAPKAPK2MAPK activated protein kinase 2. (319 aa)
M3YFD0_MUSPFUncharacterized protein. (260 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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