(17 nodes) p75NTR signals via NF-kB network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NFKB1	Nuclear factor kappa B subunit 1. (971 aa)
	NGF	Nerve growth factor; Belongs to the NGF-beta family. (241 aa)
	LOC101686900	Ubiquitin-like domain-containing protein. (127 aa)
	PRKCI	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (638 aa)
	NFKBIA	NFKB inhibitor alpha. (314 aa)
	UBA52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	NGFR	Nerve growth factor receptor. (429 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
	M3YMN0_MUSPF	Ubiquitin-like domain-containing protein. (124 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (511 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (156 aa)
	M3YFD0_MUSPF	Uncharacterized protein. (260 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (696 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	SQSTM1	Sequestosome 1. (371 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IKBKB	IRAK1	ENSMPUP00000012607	ENSMPUP00000008986	Inhibitor of nuclear factor kappa B kinase subunit beta.	Interleukin 1 receptor associated kinase 1.	0.562
IKBKB	LOC101686900	ENSMPUP00000012607	ENSMPUP00000018679	Inhibitor of nuclear factor kappa B kinase subunit beta.	Ubiquitin-like domain-containing protein.	0.465
IKBKB	M3YFD0_MUSPF	ENSMPUP00000012607	ENSMPUP00000010037	Inhibitor of nuclear factor kappa B kinase subunit beta.	Uncharacterized protein.	0.573
IKBKB	M3YMN0_MUSPF	ENSMPUP00000012607	ENSMPUP00000012587	Inhibitor of nuclear factor kappa B kinase subunit beta.	Ubiquitin-like domain-containing protein.	0.465
IKBKB	MYD88	ENSMPUP00000012607	ENSMPUP00000002726	Inhibitor of nuclear factor kappa B kinase subunit beta.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.608
IKBKB	NFKB1	ENSMPUP00000012607	ENSMPUP00000009338	Inhibitor of nuclear factor kappa B kinase subunit beta.	Nuclear factor kappa B subunit 1.	0.989
IKBKB	NFKBIA	ENSMPUP00000012607	ENSMPUP00000016183	Inhibitor of nuclear factor kappa B kinase subunit beta.	NFKB inhibitor alpha.	0.997
IKBKB	NGF	ENSMPUP00000012607	ENSMPUP00000019262	Inhibitor of nuclear factor kappa B kinase subunit beta.	Nerve growth factor; Belongs to the NGF-beta family.	0.436
IKBKB	NGFR	ENSMPUP00000012607	ENSMPUP00000015274	Inhibitor of nuclear factor kappa B kinase subunit beta.	Nerve growth factor receptor.	0.518
IKBKB	RELA	ENSMPUP00000012607	ENSMPUP00000011545	Inhibitor of nuclear factor kappa B kinase subunit beta.	RELA proto-oncogene, NF-kB subunit.	0.995
IKBKB	RIPK2	ENSMPUP00000012607	ENSMPUP00000010871	Inhibitor of nuclear factor kappa B kinase subunit beta.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.492
IKBKB	RPS27A	ENSMPUP00000012607	ENSMPUP00000010391	Inhibitor of nuclear factor kappa B kinase subunit beta.	Ubiquitin-like domain-containing protein.	0.579
IKBKB	SQSTM1	ENSMPUP00000012607	ENSMPUP00000000647	Inhibitor of nuclear factor kappa B kinase subunit beta.	Sequestosome 1.	0.575
IKBKB	TRAF6	ENSMPUP00000012607	ENSMPUP00000011691	Inhibitor of nuclear factor kappa B kinase subunit beta.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.984
IKBKB	UBA52	ENSMPUP00000012607	ENSMPUP00000015416	Inhibitor of nuclear factor kappa B kinase subunit beta.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.465
IRAK1	IKBKB	ENSMPUP00000008986	ENSMPUP00000012607	Interleukin 1 receptor associated kinase 1.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.562
IRAK1	LOC101686900	ENSMPUP00000008986	ENSMPUP00000018679	Interleukin 1 receptor associated kinase 1.	Ubiquitin-like domain-containing protein.	0.400
IRAK1	M3YFD0_MUSPF	ENSMPUP00000008986	ENSMPUP00000010037	Interleukin 1 receptor associated kinase 1.	Uncharacterized protein.	0.576
IRAK1	M3YMN0_MUSPF	ENSMPUP00000008986	ENSMPUP00000012587	Interleukin 1 receptor associated kinase 1.	Ubiquitin-like domain-containing protein.	0.400
IRAK1	MYD88	ENSMPUP00000008986	ENSMPUP00000002726	Interleukin 1 receptor associated kinase 1.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.999