(12 nodes) Thyroxine biosynthesis network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DUOX2	Dual oxidase 2. (1307 aa)
	SLC5A5	Solute carrier family 5 member 5; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (642 aa)
	M3YN22_MUSPF	EGF-like domain-containing protein. (930 aa)
	M3YLC0_MUSPF	EGF-like domain-containing protein. (710 aa)
	DUOX1	Dual oxidase 1. (1450 aa)
	M3YHJ5_MUSPF	Uncharacterized protein. (133 aa)
	IYD	Iodotyrosine deiodinase. (323 aa)
	CGA	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
	M3YBA7_MUSPF	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (132 aa)
	M3Y5B6_MUSPF	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (120 aa)
	M3XU96_MUSPF	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (200 aa)
	TSHB	Thyroid stimulating hormone subunit beta. (138 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CGA	TSHB	ENSMPUP00000009520	ENSMPUP00000001704	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	Thyroid stimulating hormone subunit beta.	0.996
DUOX1	DUOX2	ENSMPUP00000010836	ENSMPUP00000010766	Dual oxidase 1.	Dual oxidase 2.	0.844
DUOX2	DUOX1	ENSMPUP00000010766	ENSMPUP00000010836	Dual oxidase 2.	Dual oxidase 1.	0.844
DUOX2	M3YHJ5_MUSPF	ENSMPUP00000010766	ENSMPUP00000010802	Dual oxidase 2.	Uncharacterized protein.	0.930
IYD	M3Y5B6_MUSPF	ENSMPUP00000010322	ENSMPUP00000006517	Iodotyrosine deiodinase.	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	0.439
IYD	SLC5A5	ENSMPUP00000010322	ENSMPUP00000015674	Iodotyrosine deiodinase.	Solute carrier family 5 member 5; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	0.505
M3XU96_MUSPF	M3Y5B6_MUSPF	ENSMPUP00000002646	ENSMPUP00000006517	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	0.884
M3XU96_MUSPF	TSHB	ENSMPUP00000002646	ENSMPUP00000001704	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	Thyroid stimulating hormone subunit beta.	0.526
M3Y5B6_MUSPF	IYD	ENSMPUP00000006517	ENSMPUP00000010322	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	Iodotyrosine deiodinase.	0.439
M3Y5B6_MUSPF	M3XU96_MUSPF	ENSMPUP00000006517	ENSMPUP00000002646	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	0.884
M3Y5B6_MUSPF	M3YBA7_MUSPF	ENSMPUP00000006517	ENSMPUP00000008614	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	0.884
M3YBA7_MUSPF	M3Y5B6_MUSPF	ENSMPUP00000008614	ENSMPUP00000006517	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	0.884
M3YBA7_MUSPF	TSHB	ENSMPUP00000008614	ENSMPUP00000001704	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine).	Thyroid stimulating hormone subunit beta.	0.526
M3YHJ5_MUSPF	DUOX2	ENSMPUP00000010802	ENSMPUP00000010766	Uncharacterized protein.	Dual oxidase 2.	0.930
M3YLC0_MUSPF	SLC5A5	ENSMPUP00000012127	ENSMPUP00000015674	EGF-like domain-containing protein.	Solute carrier family 5 member 5; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	0.502
M3YN22_MUSPF	SLC5A5	ENSMPUP00000012729	ENSMPUP00000015674	EGF-like domain-containing protein.	Solute carrier family 5 member 5; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	0.502
SLC5A5	IYD	ENSMPUP00000015674	ENSMPUP00000010322	Solute carrier family 5 member 5; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	Iodotyrosine deiodinase.	0.505
SLC5A5	M3YLC0_MUSPF	ENSMPUP00000015674	ENSMPUP00000012127	Solute carrier family 5 member 5; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	EGF-like domain-containing protein.	0.502
SLC5A5	M3YN22_MUSPF	ENSMPUP00000015674	ENSMPUP00000012729	Solute carrier family 5 member 5; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	EGF-like domain-containing protein.	0.502
TSHB	CGA	ENSMPUP00000001704	ENSMPUP00000009520	Thyroid stimulating hormone subunit beta.	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	0.996