(72 nodes) Semaphorin interactions network (Mustela putorius)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SEMA6A	Semaphorin 6A; Belongs to the semaphorin family. (1031 aa)
	DPYSL2	Dihydropyrimidinase like 2. (572 aa)
	M3XQJ6_MUSPF	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (155 aa)
	M3XSM2_MUSPF	Uncharacterized protein. (164 aa)
	DPYSL4	Dihydropyrimidinase like 4. (601 aa)
	PLXNB2	Plexin B2. (1841 aa)
	RRAS	RAS related. (218 aa)
	HSP90AA1	HATPase_c domain-containing protein. (679 aa)
	PLXNA2	Plexin A2. (1909 aa)
	ARHGEF11	Rho guanine nucleotide exchange factor 11. (1536 aa)
	PAK2	Non-specific serine/threonine protein kinase. (524 aa)
	PAK3	P21 (RAC1) activated kinase 3. (583 aa)
	PIP5K1C	Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (653 aa)
	SEMA6C	Semaphorin 6C; Belongs to the semaphorin family. (936 aa)
	PLXNA4	Plexin A4. (1893 aa)
	SEMA4A	Semaphorin 4A; Belongs to the semaphorin family. (761 aa)
	SEMA6B	Semaphorin 6B; Belongs to the semaphorin family. (690 aa)
	ARHGAP35	Rho GTPase activating protein 35. (1500 aa)
	RHOC	Ras homolog family member C. (193 aa)
	CD72	CD72 molecule. (366 aa)
	TLN1	Talin 1. (2541 aa)
	ROCK1	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1252 aa)
	ARHGEF12	Rho guanine nucleotide exchange factor 12. (1544 aa)
	PKHD1L1	PKHD1 like 1. (4257 aa)
	TYROBP	TYRO protein tyrosine kinase binding protein. (114 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	MET	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1540 aa)
	M3Y7N6_MUSPF	Uncharacterized protein. (568 aa)
	M3Y7P8_MUSPF	Sema domain-containing protein. (708 aa)
	M3Y830_MUSPF	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (417 aa)
	CRMP1	Collapsin response mediator protein 1. (674 aa)
	DPYSL3	Dihydropyrimidinase like 3. (687 aa)
	PTK6	Tyrosine-protein kinase. (444 aa)
	CDK5	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	SRMS	Tyrosine-protein kinase. (507 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
	SEMA4D	Semaphorin 4D; Belongs to the semaphorin family. (857 aa)
	PLXNB3	Plexin B3. (1894 aa)
	PKHD1	PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (4056 aa)
	DPYSL5	Dihydropyrimidinase like 5. (573 aa)
	PLXNA3	Plexin A3. (1872 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1298 aa)
	SEMA6D	Semaphorin 6D; Belongs to the semaphorin family. (1082 aa)
	SEMA5A	Semaphorin 5A. (1073 aa)
	CFL1	Cofilin 1; Belongs to the actin-binding proteins ADF family. (165 aa)
	URB2	URB2 ribosome biogenesis homolog. (1520 aa)
	HSP90AB1	Heat shock protein 90 alpha family class B member 1. (724 aa)
	LIMK2	LIM domain kinase 2. (693 aa)
	SEMA3B	Semaphorin 3B; Belongs to the semaphorin family. (748 aa)
	ROCK2	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1389 aa)
	RHOA	Ras homolog family member A. (193 aa)
	PLXNB1	Plexin B1. (2137 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1260 aa)
	DPYS	Dihydropyrimidinase. (509 aa)
	FES	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (820 aa)
	SEMA4B	Semaphorin 4B; Belongs to the semaphorin family. (831 aa)
	PAK1	Non-specific serine/threonine protein kinase. (544 aa)
	LIMK1	LIM domain kinase 1. (626 aa)
	CFL2	Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
	SEMA3G	Semaphorin 3G; Belongs to the semaphorin family. (770 aa)
	PLXND1	Plexin D1. (1746 aa)
	SEMA7A	Semaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (663 aa)
	PLXNA1	Plexin A1. (1912 aa)
	SEMA3E	Semaphorin 3E; Belongs to the semaphorin family. (775 aa)
	SEMA3A	Semaphorin 3A; Belongs to the semaphorin family. (772 aa)
	M3Z506_MUSPF	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (165 aa)
	RHOB	Ras homolog family member B. (196 aa)
	CDK5R1	Cyclin-dependent kinase 5 activator. (307 aa)
	TLNRD1	Talin rod domain containing 1. (362 aa)
	FARP2	FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1062 aa)
	TLN2	Talin 2. (2542 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP35	FYN	ENSMPUP00000005102	ENSMPUP00000010147	Rho GTPase activating protein 35.	Tyrosine-protein kinase.	0.687
ARHGAP35	MET	ENSMPUP00000005102	ENSMPUP00000007141	Rho GTPase activating protein 35.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.617
ARHGAP35	PLXNA3	ENSMPUP00000005102	ENSMPUP00000009553	Rho GTPase activating protein 35.	Plexin A3.	0.418
ARHGAP35	PTK6	ENSMPUP00000005102	ENSMPUP00000008251	Rho GTPase activating protein 35.	Tyrosine-protein kinase.	0.687
ARHGAP35	RHOA	ENSMPUP00000005102	ENSMPUP00000013737	Rho GTPase activating protein 35.	Ras homolog family member A.	0.934
ARHGAP35	RHOB	ENSMPUP00000005102	ENSMPUP00000019359	Rho GTPase activating protein 35.	Ras homolog family member B.	0.934
ARHGAP35	RHOC	ENSMPUP00000005102	ENSMPUP00000005105	Rho GTPase activating protein 35.	Ras homolog family member C.	0.918
ARHGAP35	SEMA4D	ENSMPUP00000005102	ENSMPUP00000008412	Rho GTPase activating protein 35.	Semaphorin 4D; Belongs to the semaphorin family.	0.550
ARHGAP35	SRMS	ENSMPUP00000005102	ENSMPUP00000008286	Rho GTPase activating protein 35.	Tyrosine-protein kinase.	0.687
ARHGEF11	ARHGEF12	ENSMPUP00000003522	ENSMPUP00000005563	Rho guanine nucleotide exchange factor 11.	Rho guanine nucleotide exchange factor 12.	0.940
ARHGEF11	ERBB2	ENSMPUP00000003522	ENSMPUP00000014872	Rho guanine nucleotide exchange factor 11.	Receptor protein-tyrosine kinase.	0.548
ARHGEF11	MET	ENSMPUP00000003522	ENSMPUP00000007141	Rho guanine nucleotide exchange factor 11.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.480
ARHGEF11	PLXNB1	ENSMPUP00000003522	ENSMPUP00000014827	Rho guanine nucleotide exchange factor 11.	Plexin B1.	0.663
ARHGEF11	PLXNB2	ENSMPUP00000003522	ENSMPUP00000002239	Rho guanine nucleotide exchange factor 11.	Plexin B2.	0.916
ARHGEF11	PLXNB3	ENSMPUP00000003522	ENSMPUP00000008420	Rho guanine nucleotide exchange factor 11.	Plexin B3.	0.663
ARHGEF11	RHOA	ENSMPUP00000003522	ENSMPUP00000013737	Rho guanine nucleotide exchange factor 11.	Ras homolog family member A.	0.933
ARHGEF11	RHOB	ENSMPUP00000003522	ENSMPUP00000019359	Rho guanine nucleotide exchange factor 11.	Ras homolog family member B.	0.933
ARHGEF11	RHOC	ENSMPUP00000003522	ENSMPUP00000005105	Rho guanine nucleotide exchange factor 11.	Ras homolog family member C.	0.913
ARHGEF11	ROCK1	ENSMPUP00000003522	ENSMPUP00000005447	Rho guanine nucleotide exchange factor 11.	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.587
ARHGEF11	ROCK2	ENSMPUP00000003522	ENSMPUP00000013446	Rho guanine nucleotide exchange factor 11.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.606