(60 nodes) DNA Damage Bypass network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	UBE2L6	Ubiquitin conjugating enzyme E2 L6; Belongs to the ubiquitin-conjugating enzyme family. (148 aa)
	M3XNB3_MUSPF	PAF domain-containing protein. (111 aa)
	RCBTB2	RCC1 and BTB domain containing protein 2. (551 aa)
	CUL4B	Cullin 4B; Belongs to the cullin family. (1041 aa)
	M3XQS3_MUSPF	Uncharacterized protein. (272 aa)
	POLD1	DNA polymerase. (1107 aa)
	RFC3	Replication factor C subunit 3. (356 aa)
	WDR48	WD repeat domain 48. (429 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2275 aa)
	RFC5	Replication factor C subunit 5. (340 aa)
	RFC4	Replication factor C subunit 4. (360 aa)
	G9KHN4_MUSPF	Polymerase, delta 4. (140 aa)
	UFD1	Ubiquitin recognition factor in ER associated degradation 1. (307 aa)
	VCP	Valosin containing protein; Belongs to the AAA ATPase family. (806 aa)
	POLE2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (539 aa)
	SPRTN	SprT-like N-terminal domain. (487 aa)
	POLK	DNA polymerase kappa. (870 aa)
	RFC1	Replication factor C subunit 1. (1155 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	USP1	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (785 aa)
	USP43	Ubiquitin specific peptidase 43; Belongs to the peptidase C19 family. (996 aa)
	POLE3	DNA polymerase epsilon 3, accessory subunit. (147 aa)
	POLE4	DNA polymerase epsilon 4, accessory subunit. (114 aa)
	USP10	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (799 aa)
	M3YC47_MUSPF	Uncharacterized protein. (335 aa)
	M3YCE7_MUSPF	Uncharacterized protein. (124 aa)
	POLD3	DNA polymerase delta 3, accessory subunit. (465 aa)
	CUL4A	Cullin 4A; Belongs to the cullin family. (713 aa)
	M3YFD0_MUSPF	Uncharacterized protein. (260 aa)
	REV3L	REV3 like, DNA directed polymerase zeta catalytic subunit. (3130 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (156 aa)
	SPATA5L1	Spermatogenesis associated 5 like 1. (769 aa)
	NPLOC4	NPL4 homolog, ubiquitin recognition factor. (607 aa)
	REV1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1254 aa)
	M3YMN0_MUSPF	Ubiquitin-like domain-containing protein. (124 aa)
	POLH	DNA polymerase eta. (649 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	UBA7	Ubiquitin like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family. (1016 aa)
	TRIM65	Tripartite motif containing 65. (517 aa)
	TRIM47	Tripartite motif containing 47. (400 aa)
	ISG15	ISG15 ubiquitin like modifier. (184 aa)
	M3YRF3_MUSPF	Uncharacterized protein. (654 aa)
	DDB1	Damage specific DNA binding protein 1. (1114 aa)
	ATAD5	ATPase family AAA domain containing 5. (1892 aa)
	M3YTL6_MUSPF	DNA_pol_D_N domain-containing protein. (323 aa)
	TRIM25	Tripartite motif containing 25. (653 aa)
	UBA52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	KXD1	KxDL motif containing 1. (182 aa)
	RPA2	Replication protein A2. (270 aa)
	MEIOB	Meiosis specific with OB-fold. (471 aa)
	DTL	Denticleless E3 ubiquitin protein ligase homolog. (730 aa)
	RFC2	Replication factor C subunit 2. (352 aa)
	MAD2L2	Mitotic arrest deficient 2 like 2. (211 aa)
	RBX1	Ring-box 1. (108 aa)
	USP31	Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family. (1134 aa)
	RAD18	RAD18 E3 ubiquitin protein ligase. (501 aa)
	SPATA5	Spermatogenesis associated 5. (893 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (531 aa)
	M3Z3C9_MUSPF	Uncharacterized protein. (321 aa)
	LOC101686900	Ubiquitin-like domain-containing protein. (127 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	CUL4A	ENSMPUP00000014578	ENSMPUP00000009883	ATPase family AAA domain containing 5.	Cullin 4A; Belongs to the cullin family.	0.491
ATAD5	CUL4B	ENSMPUP00000014578	ENSMPUP00000001407	ATPase family AAA domain containing 5.	Cullin 4B; Belongs to the cullin family.	0.491
ATAD5	DDB1	ENSMPUP00000014578	ENSMPUP00000014091	ATPase family AAA domain containing 5.	Damage specific DNA binding protein 1.	0.552
ATAD5	DTL	ENSMPUP00000014578	ENSMPUP00000015754	ATPase family AAA domain containing 5.	Denticleless E3 ubiquitin protein ligase homolog.	0.772
ATAD5	M3XNB3_MUSPF	ENSMPUP00000014578	ENSMPUP00000000563	ATPase family AAA domain containing 5.	PAF domain-containing protein.	0.431
ATAD5	M3XQS3_MUSPF	ENSMPUP00000014578	ENSMPUP00000001423	ATPase family AAA domain containing 5.	Uncharacterized protein.	0.567
ATAD5	M3YC47_MUSPF	ENSMPUP00000014578	ENSMPUP00000008904	ATPase family AAA domain containing 5.	Uncharacterized protein.	0.546
ATAD5	M3YTL6_MUSPF	ENSMPUP00000014578	ENSMPUP00000014676	ATPase family AAA domain containing 5.	DNA_pol_D_N domain-containing protein.	0.537
ATAD5	M3Z3C9_MUSPF	ENSMPUP00000014578	ENSMPUP00000018091	ATPase family AAA domain containing 5.	Uncharacterized protein.	0.537
ATAD5	MAD2L2	ENSMPUP00000014578	ENSMPUP00000016318	ATPase family AAA domain containing 5.	Mitotic arrest deficient 2 like 2.	0.594
ATAD5	MEIOB	ENSMPUP00000014578	ENSMPUP00000015459	ATPase family AAA domain containing 5.	Meiosis specific with OB-fold.	0.683
ATAD5	PCNA	ENSMPUP00000014578	ENSMPUP00000006142	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.957
ATAD5	POLD1	ENSMPUP00000014578	ENSMPUP00000001797	ATPase family AAA domain containing 5.	DNA polymerase.	0.746
ATAD5	POLE	ENSMPUP00000014578	ENSMPUP00000002564	ATPase family AAA domain containing 5.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.818
ATAD5	POLE2	ENSMPUP00000014578	ENSMPUP00000004911	ATPase family AAA domain containing 5.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.770
ATAD5	POLE3	ENSMPUP00000014578	ENSMPUP00000007867	ATPase family AAA domain containing 5.	DNA polymerase epsilon 3, accessory subunit.	0.670
ATAD5	POLE4	ENSMPUP00000014578	ENSMPUP00000008293	ATPase family AAA domain containing 5.	DNA polymerase epsilon 4, accessory subunit.	0.646
ATAD5	POLH	ENSMPUP00000014578	ENSMPUP00000012801	ATPase family AAA domain containing 5.	DNA polymerase eta.	0.591
ATAD5	POLK	ENSMPUP00000014578	ENSMPUP00000005596	ATPase family AAA domain containing 5.	DNA polymerase kappa.	0.600
ATAD5	RAD18	ENSMPUP00000014578	ENSMPUP00000016955	ATPase family AAA domain containing 5.	RAD18 E3 ubiquitin protein ligase.	0.737