(86 nodes) Signaling by Insulin receptor network (Mustela putorius)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	M3YJV8_MUSPF	Uncharacterized protein. (1327 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (399 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	PDE3B	Phosphodiesterase. (889 aa)
	ATP6V1C2	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (427 aa)
	ATP6V0B	ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (205 aa)
	PTPRF	Protein tyrosine phosphatase receptor type F. (1906 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	M3YR72_MUSPF	Uncharacterized protein. (542 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
	ATP6V1C1	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (384 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (531 aa)
	ATP6V0C	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (171 aa)
	M3YW64_MUSPF	Uncharacterized protein. (513 aa)
	M3YWA8_MUSPF	Uncharacterized protein. (726 aa)
	CNST	Consortin, connexin sorting protein. (722 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (247 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	IDE	Insulin degrading enzyme; Belongs to the peptidase M16 family. (1017 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (517 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (424 aa)
	TRIB3	Tribbles pseudokinase 3. (358 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	M3Z335_MUSPF	Uncharacterized protein. (226 aa)
	GRB10	Growth factor receptor bound protein 10. (611 aa)
	M3Z792_MUSPF	Uncharacterized protein. (226 aa)
	ATP6V1E2	ATPase H+ transporting V1 subunit E2. (226 aa)
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	ATP6V1A	ATPase H+ transporting V1 subunit A. (618 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	GAB1	GRB2 associated binding protein 1. (648 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
	IRS1	Insulin receptor substrate 1. (1428 aa)
	LIM2	Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. (174 aa)
	ATP6V0A2	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (854 aa)
	ATP6V1G1	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
	LOC101681938	Protein kinase domain-containing protein. (490 aa)
	KL	Klotho. (987 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
	FLT3LG	Fms related tyrosine kinase 3 ligand. (291 aa)
	M3XV19_MUSPF	Uncharacterized protein. (123 aa)
	FGFR2	Fibroblast growth factor receptor. (842 aa)
	MAPK1	Mitogen-activated protein kinase. (333 aa)
	M3XWP6_MUSPF	Uncharacterized protein. (120 aa)
	ATP6V0A4	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (840 aa)
	FGF17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	TCIRG1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
	ATP6V1B2	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (511 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	M3XZV6_MUSPF	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (153 aa)
	FLT3	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (974 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (109 aa)
	M3Y3L0_MUSPF	Uncharacterized protein. (99 aa)
	KLB	Klotho beta. (850 aa)
	M3Y3Y6_MUSPF	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (375 aa)
	SHC1	SHC adaptor protein 1. (586 aa)
	ATP6V1F	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
	ATP6V0D1	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
	FGF5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (265 aa)
	ATP6V1D	ATPase H+ transporting V1 subunit D. (247 aa)
	NRDC	Nardilysin convertase; Belongs to the peptidase M16 family. (1164 aa)
	M3Y7E3_MUSPF	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
	ATP6V1B1	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	GAB2	GRB2 associated binding protein 2. (639 aa)
	M3Y9N6_MUSPF	Uncharacterized protein. (343 aa)
	INSR	Tyrosine-protein kinase receptor. (1352 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
	ATP6AP1	ATPase H+ transporting accessory protein 1. (464 aa)
	FGFR1	Fibroblast growth factor receptor. (856 aa)
	SPEM2	SPEM family member 2. (493 aa)
	FGF22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
	ATP6V0A1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (839 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	ATP6V1G3	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1276 aa)
	ATP6V1H	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
	ATP6V0D2	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
	FGFR3	Fibroblast growth factor receptor. (802 aa)
	M3YIA6_MUSPF	Uncharacterized protein. (333 aa)
	FGFR4	Fibroblast growth factor receptor. (801 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP6AP1	ATP6V0A1	ENSMPUP00000009375	ENSMPUP00000010275	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.999
ATP6AP1	ATP6V0A2	ENSMPUP00000009375	ENSMPUP00000001456	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.991
ATP6AP1	ATP6V0A4	ENSMPUP00000009375	ENSMPUP00000003814	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.990
ATP6AP1	ATP6V0B	ENSMPUP00000009375	ENSMPUP00000013492	ATPase H+ transporting accessory protein 1.	ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family.	0.999
ATP6AP1	ATP6V0C	ENSMPUP00000009375	ENSMPUP00000015205	ATPase H+ transporting accessory protein 1.	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.997
ATP6AP1	ATP6V0D1	ENSMPUP00000009375	ENSMPUP00000006291	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.	0.999
ATP6AP1	ATP6V0D2	ENSMPUP00000009375	ENSMPUP00000010713	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.	0.994
ATP6AP1	ATP6V1A	ENSMPUP00000009375	ENSMPUP00000000284	ATPase H+ transporting accessory protein 1.	ATPase H+ transporting V1 subunit A.	0.999
ATP6AP1	ATP6V1B1	ENSMPUP00000009375	ENSMPUP00000007270	ATPase H+ transporting accessory protein 1.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.978
ATP6AP1	ATP6V1B2	ENSMPUP00000009375	ENSMPUP00000004242	ATPase H+ transporting accessory protein 1.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.982
ATP6AP1	ATP6V1C1	ENSMPUP00000009375	ENSMPUP00000015012	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.999
ATP6AP1	ATP6V1C2	ENSMPUP00000009375	ENSMPUP00000013349	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.952
ATP6AP1	ATP6V1D	ENSMPUP00000009375	ENSMPUP00000006946	ATPase H+ transporting accessory protein 1.	ATPase H+ transporting V1 subunit D.	0.999
ATP6AP1	ATP6V1E2	ENSMPUP00000009375	ENSMPUP00000019795	ATPase H+ transporting accessory protein 1.	ATPase H+ transporting V1 subunit E2.	0.931
ATP6AP1	ATP6V1F	ENSMPUP00000009375	ENSMPUP00000006200	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.999
ATP6AP1	ATP6V1G1	ENSMPUP00000009375	ENSMPUP00000001637	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.969
ATP6AP1	ATP6V1G3	ENSMPUP00000009375	ENSMPUP00000010365	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.948
ATP6AP1	ATP6V1H	ENSMPUP00000009375	ENSMPUP00000010568	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.	0.999
ATP6AP1	CNST	ENSMPUP00000009375	ENSMPUP00000015705	ATPase H+ transporting accessory protein 1.	Consortin, connexin sorting protein.	0.870
ATP6AP1	LIM2	ENSMPUP00000009375	ENSMPUP00000001357	ATPase H+ transporting accessory protein 1.	Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family.	0.945