(108 nodes) RAB GEFs exchange GTP for GDP on RABs network (Mustela putorius)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	M3XLW0_MUSPF	DUF3543 domain-containing protein. (669 aa)
	ANKMY1	Ankyrin repeat and MYND domain containing 1. (1082 aa)
	ALS2	Alsin Rho guanine nucleotide exchange factor ALS2. (1657 aa)
	DENND4A	DENN domain containing 4A. (1872 aa)
	RAB8B	RAB8B, member RAS oncogene family. (207 aa)
	RAB5B	RAB5B, member RAS oncogene family. (244 aa)
	CHM	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. (537 aa)
	RIN2	Ras and Rab interactor 2. (905 aa)
	M3XS51_MUSPF	Uncharacterized protein. (349 aa)
	M3XS60_MUSPF	Uncharacterized protein. (576 aa)
	DENND3	DENN domain containing 3. (1151 aa)
	M3XSF2_MUSPF	Uncharacterized protein. (124 aa)
	MORN3	MORN repeat containing 3. (240 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	RAB27A	RAB27A, member RAS oncogene family. (221 aa)
	DENND6B	DENN domain containing 6B. (612 aa)
	RAB3GAP1	RAB3 GTPase activating protein catalytic subunit 1. (985 aa)
	RIN1	Ras and Rab interactor 1. (653 aa)
	RAB35	RAB35, member RAS oncogene family. (201 aa)
	DENND2A	DENN domain containing 2A. (1090 aa)
	RAB3GAP2	RAB3 GTPase activating non-catalytic protein subunit 2. (1393 aa)
	DENND2D	DENN domain containing 2D. (471 aa)
	RAB31	RAB31, member RAS oncogene family. (195 aa)
	MADD	MAP kinase activating death domain. (1606 aa)
	RAB12	RAB12, member RAS oncogene family. (186 aa)
	M3Y0J8_MUSPF	RIC1 domain-containing protein. (1058 aa)
	M3Y0L2_MUSPF	Uncharacterized protein. (230 aa)
	TRAPPC4	Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family. (219 aa)
	RGP1	RGP1 homolog, RAB6A GEF complex partner 1. (391 aa)
	DENND2C	DENN domain containing 2C. (928 aa)
	RAB39A	RAB39A, member RAS oncogene family. (176 aa)
	TRAPPC6A	Trafficking protein particle complex 6A. (159 aa)
	RAB1A	RAB1A, member RAS oncogene family. (251 aa)
	JPH4	Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (633 aa)
	DENND1C	DENN domain containing 1C. (798 aa)
	TRAPPC8	Trafficking protein particle complex 8. (1410 aa)
	GAREM1	GRB2 associated regulator of MAPK1 subtype 1. (753 aa)
	VPS9D1	VPS9 domain containing 1. (591 aa)
	MORN5	MORN repeat containing 5. (175 aa)
	RIN3	Ras and Rab interactor 3. (988 aa)
	RAB14	RAB14, member RAS oncogene family. (215 aa)
	MORN1	MORN repeat containing 1. (549 aa)
	ANKRD27	Ankyrin repeat domain 27. (1051 aa)
	M3Y931_MUSPF	Uncharacterized protein. (203 aa)
	WDR54	WD repeat domain 54. (334 aa)
	DENND4B	DENN domain containing 4B. (1400 aa)
	JPH3	Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (754 aa)
	GAREM2	GRB2 associated regulator of MAPK1 subtype 2. (849 aa)
	TRAPPC1	Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family. (145 aa)
	RSPH1	Radial spoke head component 1. (310 aa)
	GDI1	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (447 aa)
	RAB6B	RAB6B, member RAS oncogene family. (198 aa)
	RAB6A	RAB6A, member RAS oncogene family. (208 aa)
	MON1B	MON1 homolog B, secretory trafficking associated. (551 aa)
	TRAPPC10	Uncharacterized protein. (1224 aa)
	JPH1	Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (733 aa)
	M3YFV0_MUSPF	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (432 aa)
	RAB38	RAB38, member RAS oncogene family. (211 aa)
	DENND1B	DENN domain containing 1B. (413 aa)
	M3YGL9_MUSPF	Uncharacterized protein. (216 aa)
	RAB18	RAB18, member RAS oncogene family. (206 aa)
	TRAPPC11	Trafficking protein particle complex 11. (1133 aa)
	DENND5B	DENN domain containing 5B. (1296 aa)
	RAB1B	RAB1B, member RAS oncoprotein family. (210 aa)
	RAB7B	RAB7B, member RAS oncogene family. (200 aa)
	DENND2B	Suppression of tumorigenicity 5. (1132 aa)
	DENND5A	DENN domain containing 5A. (1249 aa)
	SH3YL1	SH3 and SYLF domain containing 1. (336 aa)
	SBF2	SET binding factor 2. (1987 aa)
	TRAPPC12	Trafficking protein particle complex 12. (766 aa)
	RAB5A	RAB5A, member RAS oncogene family. (215 aa)
	MON1A	MON1 homolog A, secretory trafficking associated. (555 aa)
	HPS4	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2. (746 aa)
	YWHAE	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (251 aa)
	GRIPAP1	GRIP1 associated protein 1. (841 aa)
	GAPVD1	GTPase activating protein and VPS9 domains 1. (1460 aa)
	DENND1A	DENN domain containing 1A. (1074 aa)
	RAB3IL1	RAB3A interacting protein like 1. (429 aa)
	ENSMPUP00000014058	annotation not available (213 aa)
	TRAPPC13	Trafficking protein particle complex 13. (411 aa)
	TRAPPC3	Trafficking protein particle complex subunit; May play a role in vesicular transport from endoplasmic reticulum to Golgi. (180 aa)
	ALS2CL	ALS2 C-terminal like. (951 aa)
	RAB3A	RAB3A, member RAS oncogene family. (220 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
	DENND4C	DENN domain containing 4C. (1913 aa)
	RAB8A	RAB8A, member RAS oncogene family. (207 aa)
	RAB39B	RAB39B, member RAS oncogene family. (213 aa)
	M3YXN1_MUSPF	Uncharacterized protein. (506 aa)
	TRAPPC6B	Trafficking protein particle complex 6B. (164 aa)
	GDI2	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (423 aa)
	M3YYD2_MUSPF	Uncharacterized protein. (397 aa)
	RAB27B	RAB27B, member RAS oncogene family. (218 aa)
	M3YYQ6_MUSPF	Uncharacterized protein. (479 aa)
	M3YYQ8_MUSPF	Uncharacterized protein. (873 aa)
	DENND6A	DENN domain containing 6A. (525 aa)
	HPS1	HPS1 biogenesis of lysosomal organelles complex 3 subunit 1. (698 aa)
	MORN4	MORN repeat containing 4. (146 aa)
	RAB7A	RAB7A, member RAS oncogene family. (207 aa)
	M3Z176_MUSPF	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (221 aa)
	RAB21	RAB21, member RAS oncogene family. (224 aa)
	M3Z1C4_MUSPF	Sec2p domain-containing protein. (472 aa)
	JPH2	Junctophilin 2. (649 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	RINL	Ras and Rab interactor like. (568 aa)
	RAB32	RAB32, member RAS oncogene family. (223 aa)
	LCA5	Lebercilin LCA5. (698 aa)
	RAB9A	RAB9A, member RAS oncogene family. (201 aa)
	RAB9B	RAB9B, member RAS oncogene family. (201 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT2	ENSMPUP00000002136	ENSMPUP00000017599	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.815
AKT1	AKT3	ENSMPUP00000002136	ENSMPUP00000015621	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.833
AKT2	AKT1	ENSMPUP00000017599	ENSMPUP00000002136	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.815
AKT2	AKT3	ENSMPUP00000017599	ENSMPUP00000015621	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.833
AKT3	AKT1	ENSMPUP00000015621	ENSMPUP00000002136	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.833
AKT3	AKT2	ENSMPUP00000015621	ENSMPUP00000017599	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.833
ALS2	ALS2CL	ENSMPUP00000000312	ENSMPUP00000015055	Alsin Rho guanine nucleotide exchange factor ALS2.	ALS2 C-terminal like.	0.447
ALS2	ANKRD27	ENSMPUP00000000312	ENSMPUP00000007763	Alsin Rho guanine nucleotide exchange factor ALS2.	Ankyrin repeat domain 27.	0.506
ALS2	GAPVD1	ENSMPUP00000000312	ENSMPUP00000013777	Alsin Rho guanine nucleotide exchange factor ALS2.	GTPase activating protein and VPS9 domains 1.	0.623
ALS2	GDI1	ENSMPUP00000000312	ENSMPUP00000009386	Alsin Rho guanine nucleotide exchange factor ALS2.	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	0.546
ALS2	GDI2	ENSMPUP00000000312	ENSMPUP00000016234	Alsin Rho guanine nucleotide exchange factor ALS2.	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	0.546
ALS2	M3YGL9_MUSPF	ENSMPUP00000000312	ENSMPUP00000010476	Alsin Rho guanine nucleotide exchange factor ALS2.	Uncharacterized protein.	0.561
ALS2	M3YXN1_MUSPF	ENSMPUP00000000312	ENSMPUP00000016091	Alsin Rho guanine nucleotide exchange factor ALS2.	Uncharacterized protein.	0.899
ALS2	RAB31	ENSMPUP00000000312	ENSMPUP00000004595	Alsin Rho guanine nucleotide exchange factor ALS2.	RAB31, member RAS oncogene family.	0.527
ALS2	RAB5A	ENSMPUP00000000312	ENSMPUP00000013050	Alsin Rho guanine nucleotide exchange factor ALS2.	RAB5A, member RAS oncogene family.	0.949
ALS2	RAB5B	ENSMPUP00000000312	ENSMPUP00000000940	Alsin Rho guanine nucleotide exchange factor ALS2.	RAB5B, member RAS oncogene family.	0.561
ALS2	RIN1	ENSMPUP00000000312	ENSMPUP00000002952	Alsin Rho guanine nucleotide exchange factor ALS2.	Ras and Rab interactor 1.	0.612
ALS2	RIN2	ENSMPUP00000000312	ENSMPUP00000001220	Alsin Rho guanine nucleotide exchange factor ALS2.	Ras and Rab interactor 2.	0.429
ALS2	RIN3	ENSMPUP00000000312	ENSMPUP00000007455	Alsin Rho guanine nucleotide exchange factor ALS2.	Ras and Rab interactor 3.	0.669
ALS2	RINL	ENSMPUP00000000312	ENSMPUP00000017642	Alsin Rho guanine nucleotide exchange factor ALS2.	Ras and Rab interactor like.	0.425