(38 nodes) RHOH GTPase cycle network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ARHGDIB	Rho GDP dissociation inhibitor beta. (200 aa)
	ZAP70	Tyrosine-protein kinase. (616 aa)
	SPATA5L1	Spermatogenesis associated 5 like 1. (769 aa)
	JUP	Junction plakoglobin. (744 aa)
	UBXN2B	UBX domain protein 2B. (330 aa)
	LAMTOR1	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
	PAK6	Non-specific serine/threonine protein kinase. (688 aa)
	STOM	Stomatin. (288 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
	VAMP3	Vesicle associated membrane protein 3. (120 aa)
	TMEM59	Transmembrane protein 59. (320 aa)
	PAK5	Non-specific serine/threonine protein kinase. (719 aa)
	ROCK1	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1252 aa)
	PAK2	Non-specific serine/threonine protein kinase. (524 aa)
	TFRC	Transferrin receptor protein 1. (770 aa)
	VCP	Valosin containing protein; Belongs to the AAA ATPase family. (806 aa)
	SLC1A5	Amino acid transporter. (541 aa)
	RHOH	Ras homolog family member H. (191 aa)
	M3XLW8_MUSPF	Uncharacterized protein. (183 aa)
	FAM91A1	Family with sequence similarity 91 member A1. (837 aa)
	RALGAPA2	Ral GTPase activating protein catalytic alpha subunit 2. (1859 aa)
	VANGL1	Vang-like protein. (524 aa)
	WDR11	WD repeat domain 11. (1200 aa)
	NSFL1C	NSFL1 cofactor. (370 aa)
	PAK4	Non-specific serine/threonine protein kinase. (592 aa)
	SPATA5	Spermatogenesis associated 5. (893 aa)
	RAB7A	RAB7A, member RAS oncogene family. (207 aa)
	CSK	Tyrosine-protein kinase. (450 aa)
	UACA	Uveal autoantigen with coiled-coil domains and ankyrin repeats. (1417 aa)
	RALGAPA1	Ral GTPase activating protein catalytic alpha subunit 1. (2038 aa)
	NIPSNAP2	Nipsnap homolog 2. (294 aa)
	PAK1	Non-specific serine/threonine protein kinase. (544 aa)
	ROCK2	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1389 aa)
	NIPSNAP1	Nipsnap homolog 1. (284 aa)
	MTR	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1265 aa)
	DBT	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (516 aa)
	SLC4A7	Anion exchange protein. (1011 aa)
	DBN1	Drebrin 1. (656 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGDIB	M3XLW8_MUSPF	ENSMPUP00000011503	ENSMPUP00000000068	Rho GDP dissociation inhibitor beta.	Uncharacterized protein.	0.931
ARHGDIB	RHOH	ENSMPUP00000011503	ENSMPUP00000020022	Rho GDP dissociation inhibitor beta.	Ras homolog family member H.	0.801
CAV1	CSK	ENSMPUP00000007166	ENSMPUP00000017191	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Tyrosine-protein kinase.	0.759
CAV1	JUP	ENSMPUP00000007166	ENSMPUP00000010784	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Junction plakoglobin.	0.479
CAV1	RAB7A	ENSMPUP00000007166	ENSMPUP00000017223	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	RAB7A, member RAS oncogene family.	0.410
CAV1	RHOH	ENSMPUP00000007166	ENSMPUP00000020022	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Ras homolog family member H.	0.575
CAV1	ROCK1	ENSMPUP00000007166	ENSMPUP00000005447	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.466
CAV1	ROCK2	ENSMPUP00000007166	ENSMPUP00000013446	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.415
CAV1	STOM	ENSMPUP00000007166	ENSMPUP00000007419	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Stomatin.	0.425
CAV1	TFRC	ENSMPUP00000007166	ENSMPUP00000003963	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Transferrin receptor protein 1.	0.834
CAV1	VCP	ENSMPUP00000007166	ENSMPUP00000004552	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Valosin containing protein; Belongs to the AAA ATPase family.	0.487
CSK	CAV1	ENSMPUP00000017191	ENSMPUP00000007166	Tyrosine-protein kinase.	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	0.759
CSK	JUP	ENSMPUP00000017191	ENSMPUP00000010784	Tyrosine-protein kinase.	Junction plakoglobin.	0.420
CSK	RHOH	ENSMPUP00000017191	ENSMPUP00000020022	Tyrosine-protein kinase.	Ras homolog family member H.	0.585
CSK	VCP	ENSMPUP00000017191	ENSMPUP00000004552	Tyrosine-protein kinase.	Valosin containing protein; Belongs to the AAA ATPase family.	0.405
CSK	ZAP70	ENSMPUP00000017191	ENSMPUP00000011220	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.535
DBT	JUP	ENSMPUP00000012030	ENSMPUP00000010784	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Junction plakoglobin.	0.426
DBT	MTR	ENSMPUP00000012030	ENSMPUP00000012641	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.546
DBT	NIPSNAP1	ENSMPUP00000012030	ENSMPUP00000013210	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Nipsnap homolog 1.	0.478
DBT	NIPSNAP2	ENSMPUP00000012030	ENSMPUP00000016125	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Nipsnap homolog 2.	0.478