(35 nodes) FOXO-mediated transcription network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EP300	E1A binding protein p300. (2425 aa)
	SMAD3	Mothers against decapentaplegic homolog. (414 aa)
	SMAD2	Mothers against decapentaplegic homolog. (495 aa)
	GDF11	Growth differentiation factor 11. (404 aa)
	DDIT3	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	BCL6	BCL6 transcription repressor. (706 aa)
	FOXO4	Forkhead box O4. (509 aa)
	FOXG1	Forkhead box G1. (424 aa)
	AGRP	Agouti related neuropeptide. (132 aa)
	BTG1	BTG anti-proliferation factor 1. (171 aa)
	CCNG2	Cyclin G2; Belongs to the cyclin family. (343 aa)
	SIRT3	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (373 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	M3YEF8_MUSPF	FOXO-TAD domain-containing protein. (399 aa)
	FOXO3	Forkhead box O3. (671 aa)
	BCL6B	BCL6B transcription repressor. (479 aa)
	M3YJA7_MUSPF	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (228 aa)
	SIRT1	Sirtuin 1. (557 aa)
	NFYB	Nuclear transcription factor Y subunit beta. (207 aa)
	MSTN	Myostatin. (375 aa)
	M3YP02_MUSPF	PCAF_N domain-containing protein. (92 aa)
	M3YP04_MUSPF	Uncharacterized protein. (675 aa)
	YWHAQ	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (245 aa)
	NFYA	Nuclear transcription factor Y subunit alpha. (347 aa)
	FOXO6	Forkhead box O6. (367 aa)
	NFYC	Nuclear transcription factor Y subunit gamma. (335 aa)
	CREBBP	CREB binding protein. (2442 aa)
	YWHAZ	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
	YWHAG	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (796 aa)
	YWHAB	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (204 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	SFN	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGRP	M3YEF8_MUSPF	ENSMPUP00000006306	ENSMPUP00000009715	Agouti related neuropeptide.	FOXO-TAD domain-containing protein.	0.608
AKT1	AKT2	ENSMPUP00000002136	ENSMPUP00000017599	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.815
AKT1	AKT3	ENSMPUP00000002136	ENSMPUP00000015621	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.833
AKT1	FOXO3	ENSMPUP00000002136	ENSMPUP00000009773	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O3.	0.928
AKT1	FOXO4	ENSMPUP00000002136	ENSMPUP00000004600	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O4.	0.921
AKT1	FOXO6	ENSMPUP00000002136	ENSMPUP00000013974	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O6.	0.921
AKT1	M3YEF8_MUSPF	ENSMPUP00000002136	ENSMPUP00000009715	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	FOXO-TAD domain-containing protein.	0.929
AKT1	SMAD4	ENSMPUP00000002136	ENSMPUP00000008705	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mothers against decapentaplegic homolog.	0.419
AKT2	AKT1	ENSMPUP00000017599	ENSMPUP00000002136	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.815
AKT2	AKT3	ENSMPUP00000017599	ENSMPUP00000015621	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.833
AKT2	FOXO3	ENSMPUP00000017599	ENSMPUP00000009773	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O3.	0.928
AKT2	FOXO4	ENSMPUP00000017599	ENSMPUP00000004600	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O4.	0.921
AKT2	FOXO6	ENSMPUP00000017599	ENSMPUP00000013974	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O6.	0.921
AKT2	M3YEF8_MUSPF	ENSMPUP00000017599	ENSMPUP00000009715	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	FOXO-TAD domain-containing protein.	0.929
AKT2	SMAD4	ENSMPUP00000017599	ENSMPUP00000008705	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mothers against decapentaplegic homolog.	0.415
AKT3	AKT1	ENSMPUP00000015621	ENSMPUP00000002136	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.833
AKT3	AKT2	ENSMPUP00000015621	ENSMPUP00000017599	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.833
AKT3	FOXG1	ENSMPUP00000015621	ENSMPUP00000005386	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box G1.	0.457
AKT3	FOXO3	ENSMPUP00000015621	ENSMPUP00000009773	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O3.	0.971
AKT3	FOXO4	ENSMPUP00000015621	ENSMPUP00000004600	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O4.	0.969