STRINGSTRING
IL2 IL2 GAPDH GAPDH IFNB1 IFNB1 INHBA INHBA JAK1 JAK1 TLR4 TLR4 OAS1 OAS1 RPL13A RPL13A CSF1 CSF1 TGFA TGFA FAM3B FAM3B MX1 MX1 IL1A IL1A EIF2AK2 EIF2AK2 IL19 IL19 IL10 IL10 IL7 IL7 IL4 IL4 IL13 IL13 IL1B IL1B B2M B2M TNFSF13B TNFSF13B TNF TNF CSF2 CSF2 IL6 IL6 IL15 IL15 ACTB ACTB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (152 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
IFNB1Interferon beta. (186 aa)
INHBAInhibin subunit beta A. (424 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
OAS12'-5'-oligoadenylate synthetase 1. (400 aa)
RPL13ARibosomal protein L13a; Belongs to the universal ribosomal protein uL13 family. (203 aa)
CSF1Colony stimulating factor 1. (517 aa)
TGFATransforming growth factor alpha. (158 aa)
FAM3BFamily with sequence similarity 3 member B. (181 aa)
MX1Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (670 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (270 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (518 aa)
IL19Interleukin 19. (177 aa)
IL10Interleukin 10. (220 aa)
IL7Interleukin 7. (158 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (132 aa)
IL13Interleukin 13. (128 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (128 aa)
TNFSF13BTNF superfamily member 13b; Belongs to the tumor necrosis factor family. (290 aa)
TNFTumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
CSF2Colony stimulating factor 2. (148 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
ACTBActin beta. (375 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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