STRINGSTRING
ESR1 ESR1 TRPV2 TRPV2 CNN2 CNN2 GEM GEM M3YC35_MUSPF M3YC35_MUSPF ANXA1 ANXA1 TRPC6 TRPC6 ICAM1 ICAM1 ANXA4 ANXA4 ANXA3 ANXA3 PLEK PLEK HMGCR HMGCR INS INS ROCK1 ROCK1 EZR EZR TRPM5 TRPM5 RGS2 RGS2 ANXA9 ANXA9 TRPC5 TRPC5 TRPV4 TRPV4 ANXA11 ANXA11 ANXA7 ANXA7 VCL VCL RDX RDX M3XW50_MUSPF M3XW50_MUSPF PXN PXN TRPM4 TRPM4 CASQ2 CASQ2 ANXA13 ANXA13 IRS1 IRS1 MSN MSN M3XNW0_MUSPF M3XNW0_MUSPF EDN1 EDN1 NPY NPY ANXA6 ANXA6 RHOA RHOA CASQ1 CASQ1 TRPC4 TRPC4 LCK LCK MTOR MTOR PRKCD PRKCD TRPC3 TRPC3 STIM1 STIM1 ANXA5 ANXA5 MMP9 MMP9 ANXA2 ANXA2 M3Z7R1_MUSPF M3Z7R1_MUSPF IL1B IL1B TRPC1 TRPC1 VCAM1 VCAM1 PRKCB PRKCB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (597 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (766 aa)
CNN2Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (369 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
M3YC35_MUSPFAnnexin. (327 aa)
ANXA1Annexin. (345 aa)
TRPC6Transient receptor potential cation channel subfamily C member 6; Belongs to the transient receptor (TC 1.A.4) family. (846 aa)
ICAM1Intercellular adhesion molecule 1. (589 aa)
ANXA4Annexin. (323 aa)
ANXA3Annexin. (323 aa)
PLEKPleckstrin. (350 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (914 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (109 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1252 aa)
EZREzrin. (586 aa)
TRPM5Transient receptor potential cation channel subfamily M member 5. (1152 aa)
RGS2Regulator of G protein signaling 2. (211 aa)
ANXA9Annexin. (345 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (974 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (873 aa)
ANXA11Annexin. (505 aa)
ANXA7Annexin. (463 aa)
VCLVinculin. (1134 aa)
RDXRadixin. (604 aa)
M3XW50_MUSPFCalponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (329 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (590 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1211 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (505 aa)
ANXA13Annexin. (287 aa)
IRS1Insulin receptor substrate 1. (1428 aa)
MSNMoesin. (577 aa)
M3XNW0_MUSPFAnnexin. (340 aa)
EDN1Endothelin 1. (202 aa)
NPYNeuropeptide Y. (97 aa)
ANXA6Annexin. (673 aa)
RHOARas homolog family member A. (193 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (402 aa)
TRPC4Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (977 aa)
LCKTyrosine-protein kinase. (509 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2552 aa)
PRKCDProtein kinase C. (730 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (866 aa)
STIM1Stromal interaction molecule 1. (755 aa)
ANXA5Annexin. (321 aa)
MMP9Matrix metallopeptidase 9. (704 aa)
ANXA2Annexin. (344 aa)
M3Z7R1_MUSPFAnnexin. (339 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (743 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (577 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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