(44 nodes) (2018) Induction and Subversion of Human Protective Immunity: Contrasting Influenza and Respiratory Syncytial Virus. network (Mustela putorius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CD69	CD69 molecule. (199 aa)
	CD80	CD80 molecule. (302 aa)
	CXCL11	C-X-C motif chemokine. (132 aa)
	CXCL10	C-X-C motif chemokine. (98 aa)
	CXCL9	C-X-C motif chemokine. (155 aa)
	MAVS	Mitochondrial antiviral signaling protein. (524 aa)
	MX2	MX dynamin like GTPase 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (717 aa)
	MX1	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (670 aa)
	IL10	Interleukin 10. (220 aa)
	CCR10	C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (132 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (764 aa)
	TNF	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
	RNASEL	Ribonuclease L. (726 aa)
	STAT1	Signal transducer and activator of transcription. (750 aa)
	IL21R	Interleukin 21 receptor. (539 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
	FOXP3	Forkhead box P3. (433 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
	CCR2	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (337 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
	IL33	Interleukin 33. (268 aa)
	CD4	CD4. (462 aa)
	IL22	Interleukin 22. (178 aa)
	TBK1	TANK-binding kinase 1. (729 aa)
	TLR2	Toll like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
	CX3CR1	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (356 aa)
	CCR5	C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (352 aa)
	CCR1	C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
	ICOS	Inducible T-cell co-stimulator. (209 aa)
	STAT2	Signal transducer and activator of transcription. (848 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
	IRF3	Interferon regulatory factor 3. (421 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1083 aa)
	TLR8	Toll like receptor 8; Belongs to the Toll-like receptor family. (1087 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1013 aa)
	BCL6	BCL6 transcription repressor. (706 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (952 aa)
	CXCR3	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa)
	GZMB	Granzyme B; Belongs to the peptidase S1 family. (258 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL6	CCR7	ENSMPUP00000003385	ENSMPUP00000014564	BCL6 transcription repressor.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.603
BCL6	CD4	ENSMPUP00000003385	ENSMPUP00000016704	BCL6 transcription repressor.	CD4.	0.538
BCL6	CD40LG	ENSMPUP00000003385	ENSMPUP00000001876	BCL6 transcription repressor.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.805
BCL6	CD80	ENSMPUP00000003385	ENSMPUP00000008360	BCL6 transcription repressor.	CD80 molecule.	0.548
BCL6	CXCR3	ENSMPUP00000003385	ENSMPUP00000005225	BCL6 transcription repressor.	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.508
BCL6	FOXP3	ENSMPUP00000003385	ENSMPUP00000013948	BCL6 transcription repressor.	Forkhead box P3.	0.817
BCL6	ICOS	ENSMPUP00000003385	ENSMPUP00000000422	BCL6 transcription repressor.	Inducible T-cell co-stimulator.	0.968
BCL6	IL10	ENSMPUP00000003385	ENSMPUP00000009891	BCL6 transcription repressor.	Interleukin 10.	0.512
BCL6	IL21R	ENSMPUP00000003385	ENSMPUP00000012853	BCL6 transcription repressor.	Interleukin 21 receptor.	0.851
BCL6	IL4	ENSMPUP00000003385	ENSMPUP00000010424	BCL6 transcription repressor.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.791
BCL6	IL6	ENSMPUP00000003385	ENSMPUP00000013489	BCL6 transcription repressor.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.521
BCL6	STAT1	ENSMPUP00000003385	ENSMPUP00000012436	BCL6 transcription repressor.	Signal transducer and activator of transcription.	0.565
CCR1	CCR10	ENSMPUP00000019530	ENSMPUP00000010100	C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family.	0.696
CCR1	CCR2	ENSMPUP00000019530	ENSMPUP00000015187	C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.775
CCR1	CCR5	ENSMPUP00000019530	ENSMPUP00000019524	C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family.	0.969
CCR1	CCR7	ENSMPUP00000019530	ENSMPUP00000014564	C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.717
CCR1	CD4	ENSMPUP00000019530	ENSMPUP00000016704	C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	CD4.	0.433
CCR1	CX3CR1	ENSMPUP00000019530	ENSMPUP00000018898	C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.495
CCR1	CXCL10	ENSMPUP00000019530	ENSMPUP00000008619	C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine.	0.926
CCR1	CXCL11	ENSMPUP00000019530	ENSMPUP00000008613	C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine.	0.899