node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CASP3 | IL10 | ENSMPUP00000010994 | ENSMPUP00000009891 | Caspase 3; Belongs to the peptidase C14A family. | Interleukin 10. | 0.622 |
CASP3 | IL1B | ENSMPUP00000010994 | ENSMPUP00000010696 | Caspase 3; Belongs to the peptidase C14A family. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.818 |
CASP3 | INS | ENSMPUP00000010994 | ENSMPUP00000005593 | Caspase 3; Belongs to the peptidase C14A family. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.710 |
GCG | INS | ENSMPUP00000000556 | ENSMPUP00000005593 | Glucagon. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.829 |
IL10 | CASP3 | ENSMPUP00000009891 | ENSMPUP00000010994 | Interleukin 10. | Caspase 3; Belongs to the peptidase C14A family. | 0.622 |
IL10 | IL1B | ENSMPUP00000009891 | ENSMPUP00000010696 | Interleukin 10. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.946 |
IL10 | INS | ENSMPUP00000009891 | ENSMPUP00000005593 | Interleukin 10. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.621 |
IL1B | CASP3 | ENSMPUP00000010696 | ENSMPUP00000010994 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Caspase 3; Belongs to the peptidase C14A family. | 0.818 |
IL1B | IL10 | ENSMPUP00000010696 | ENSMPUP00000009891 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Interleukin 10. | 0.946 |
IL1B | INS | ENSMPUP00000010696 | ENSMPUP00000005593 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.709 |
INS | CASP3 | ENSMPUP00000005593 | ENSMPUP00000010994 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Caspase 3; Belongs to the peptidase C14A family. | 0.710 |
INS | GCG | ENSMPUP00000005593 | ENSMPUP00000000556 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Glucagon. | 0.829 |
INS | IL10 | ENSMPUP00000005593 | ENSMPUP00000009891 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Interleukin 10. | 0.621 |
INS | IL1B | ENSMPUP00000005593 | ENSMPUP00000010696 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.709 |