(8 nodes) (2019) Back to the Future for Influenza Preimmunity-Looking Back at Influenza Virus History to Infer the Outcome of Future Infections. network (Mustela putorius)

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second shell of interactors

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Your Input:
	IGHM	Immunoglobulin heavy constant mu. (452 aa)
	CXCR3	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (152 aa)
	CD4	CD4. (462 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
	TNF	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (132 aa)
	IL10	Interleukin 10. (220 aa)

Your Current Organism:

Mustela putorius

NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCR7	CD4	ENSMPUP00000014564	ENSMPUP00000016704	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	CD4.	0.824
CCR7	CXCR3	ENSMPUP00000014564	ENSMPUP00000005225	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.446
CCR7	IL10	ENSMPUP00000014564	ENSMPUP00000009891	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Interleukin 10.	0.666
CCR7	IL2	ENSMPUP00000014564	ENSMPUP00000017283	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.621
CCR7	IL4	ENSMPUP00000014564	ENSMPUP00000010424	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.634
CCR7	TNF	ENSMPUP00000014564	ENSMPUP00000011297	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	0.706
CD4	CCR7	ENSMPUP00000016704	ENSMPUP00000014564	CD4.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.824
CD4	CXCR3	ENSMPUP00000016704	ENSMPUP00000005225	CD4.	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.654
CD4	IL10	ENSMPUP00000016704	ENSMPUP00000009891	CD4.	Interleukin 10.	0.881
CD4	IL2	ENSMPUP00000016704	ENSMPUP00000017283	CD4.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.877
CD4	IL4	ENSMPUP00000016704	ENSMPUP00000010424	CD4.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.870
CD4	TNF	ENSMPUP00000016704	ENSMPUP00000011297	CD4.	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	0.858
CXCR3	CCR7	ENSMPUP00000005225	ENSMPUP00000014564	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.446
CXCR3	CD4	ENSMPUP00000005225	ENSMPUP00000016704	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	CD4.	0.654
CXCR3	IL10	ENSMPUP00000005225	ENSMPUP00000009891	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	Interleukin 10.	0.578
CXCR3	IL2	ENSMPUP00000005225	ENSMPUP00000017283	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.563
CXCR3	IL4	ENSMPUP00000005225	ENSMPUP00000010424	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.578
CXCR3	TNF	ENSMPUP00000005225	ENSMPUP00000011297	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	Tumor necrosis factor alpha; Belongs to the tumor necrosis factor family.	0.572
IL10	CCR7	ENSMPUP00000009891	ENSMPUP00000014564	Interleukin 10.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.666
IL10	CD4	ENSMPUP00000009891	ENSMPUP00000016704	Interleukin 10.	CD4.	0.881