node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DPP4 | GCG | ENSMPUP00000000549 | ENSMPUP00000000556 | Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. | Glucagon. | 0.948 |
DPP4 | GCGR | ENSMPUP00000000549 | ENSMPUP00000011260 | Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. | Glucagon receptor; Belongs to the G-protein coupled receptor 2 family. | 0.665 |
DPP4 | IL1B | ENSMPUP00000000549 | ENSMPUP00000010696 | Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.452 |
DPP4 | INS | ENSMPUP00000000549 | ENSMPUP00000005593 | Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.801 |
GCG | DPP4 | ENSMPUP00000000556 | ENSMPUP00000000549 | Glucagon. | Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. | 0.948 |
GCG | GCGR | ENSMPUP00000000556 | ENSMPUP00000011260 | Glucagon. | Glucagon receptor; Belongs to the G-protein coupled receptor 2 family. | 0.989 |
GCG | INS | ENSMPUP00000000556 | ENSMPUP00000005593 | Glucagon. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.829 |
GCGR | DPP4 | ENSMPUP00000011260 | ENSMPUP00000000549 | Glucagon receptor; Belongs to the G-protein coupled receptor 2 family. | Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. | 0.665 |
GCGR | GCG | ENSMPUP00000011260 | ENSMPUP00000000556 | Glucagon receptor; Belongs to the G-protein coupled receptor 2 family. | Glucagon. | 0.989 |
GCGR | INS | ENSMPUP00000011260 | ENSMPUP00000005593 | Glucagon receptor; Belongs to the G-protein coupled receptor 2 family. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.561 |
IL1B | DPP4 | ENSMPUP00000010696 | ENSMPUP00000000549 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. | 0.452 |
IL1B | INS | ENSMPUP00000010696 | ENSMPUP00000005593 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.709 |
INS | DPP4 | ENSMPUP00000005593 | ENSMPUP00000000549 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. | 0.801 |
INS | GCG | ENSMPUP00000005593 | ENSMPUP00000000556 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Glucagon. | 0.829 |
INS | GCGR | ENSMPUP00000005593 | ENSMPUP00000011260 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Glucagon receptor; Belongs to the G-protein coupled receptor 2 family. | 0.561 |
INS | IL1B | ENSMPUP00000005593 | ENSMPUP00000010696 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.709 |