STRINGSTRING
EGFR EGFR SRC SRC TGM2 TGM2 TGFB1 TGFB1 CD4 CD4 IL33 IL33 CALR3 CALR3 ATF3 ATF3 FASLG FASLG ABCA3 ABCA3 POSTN POSTN ORMDL3 ORMDL3 GPX1 GPX1 IL6 IL6 PDIA6 PDIA6 LOX LOX STAT4 STAT4 STAT1 STAT1 ERN2 ERN2 VCAM1 VCAM1 TRAF6 TRAF6 RELA RELA QSOX1 QSOX1 TNF TNF CASP3 CASP3 IL1B IL1B CHAC2 CHAC2 STAT5B STAT5B STAT5A STAT5A STAT3 STAT3 IL13 IL13 PDIA3 PDIA3 NOX4 NOX4 GSR GSR TGFB3 TGFB3 EGF EGF SIRT3 SIRT3 TXN TXN DPEP1 DPEP1 CFTR CFTR DPEP2 DPEP2 DPEP3 DPEP3 GPX7 GPX7 TIRAP TIRAP TOLLIP TOLLIP M3Y105_MUSPF M3Y105_MUSPF GLRX2 GLRX2 PDIA5 PDIA5 GLRX GLRX CALR CALR MCU MCU SFTPC SFTPC ATF6 ATF6 LOXL2 LOXL2 SPDEF SPDEF GLRX5 GLRX5 GGT5 GGT5 MYD88 MYD88 GLRX3 GLRX3 STAT6 STAT6 STAT2 STAT2 CANX CANX TXNDC5 TXNDC5 CASP8 CASP8 PRDX4 PRDX4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EGFRReceptor protein-tyrosine kinase. (1207 aa)
SRCTyrosine-protein kinase. (536 aa)
TGM2Transglutaminase 2. (687 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
CD4CD4. (462 aa)
IL33Interleukin 33. (268 aa)
CALR3Calreticulin. (385 aa)
ATF3Activating transcription factor 3. (181 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (275 aa)
ABCA3ATP binding cassette subfamily A member 3. (1603 aa)
POSTNPeriostin. (861 aa)
ORMDL3ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
GPX1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (154 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
PDIA6Protein disulfide isomerase family A member 6; Belongs to the protein disulfide isomerase family. (442 aa)
LOXLysyl oxidase. (415 aa)
STAT4Signal transducer and activator of transcription. (827 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
ERN2Endoplasmic reticulum to nucleus signaling 2. (926 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
RELARELA proto-oncogene, NF-kB subunit. (511 aa)
QSOX1Sulfhydryl oxidase. (621 aa)
TNFTumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
CHAC2Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (184 aa)
STAT5BSignal transducer and activator of transcription. (691 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
IL13Interleukin 13. (128 aa)
PDIA3Protein disulfide-isomerase. (505 aa)
NOX4NADPH oxidase 4. (578 aa)
GSRGlutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (481 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (373 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
DPEP1Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (410 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1484 aa)
DPEP2Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (480 aa)
DPEP3Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (492 aa)
GPX7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (261 aa)
TIRAPTIR domain containing adaptor protein. (227 aa)
TOLLIPToll interacting protein. (274 aa)
M3Y105_MUSPFSuperoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
GLRX2Glutaredoxin 2. (157 aa)
PDIA5Protein disulfide isomerase family A member 5. (520 aa)
GLRXGlutaredoxin. (106 aa)
CALRCalreticulin. (417 aa)
MCUMitochondrial calcium uniporter. (350 aa)
SFTPCSurfactant protein C. (190 aa)
ATF6Activating transcription factor 6. (659 aa)
LOXL2Lysyl oxidase like 2. (772 aa)
SPDEFSAM pointed domain containing ETS transcription factor. (335 aa)
GLRX5Glutaredoxin 5. (119 aa)
GGT5Gamma-glutamyltransferase 5. (534 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
GLRX3Glutaredoxin 3. (287 aa)
STAT6Signal transducer and activator of transcription. (844 aa)
STAT2Signal transducer and activator of transcription. (848 aa)
CANXCalnexin. (484 aa)
TXNDC5Thioredoxin domain containing 5; Belongs to the protein disulfide isomerase family. (323 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (484 aa)
PRDX4Peroxiredoxin 4. (275 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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