STRINGSTRING
TIGIT TIGIT IRAK4 IRAK4 NLRX1 NLRX1 ATG14 ATG14 APOE APOE TNFSF14 TNFSF14 IL6R IL6R IL11 IL11 IRF4 IRF4 CXCL11 CXCL11 CXCL10 CXCL10 MAVS MAVS TMPRSS2 TMPRSS2 IRAK1 IRAK1 TGFB3 TGFB3 AREG AREG ICOS ICOS GNLY GNLY ELANE ELANE ATG5 ATG5 IL10 IL10 IL7 IL7 IL4 IL4 STAT3 STAT3 IL1B IL1B KRT19 KRT19 CASP3 CASP3 TLR3 TLR3 LTB LTB TNF TNF RNASEL RNASEL JAK1 JAK1 ATG12 ATG12 RNF41 RNF41 CCL20 CCL20 CTSB CTSB NCR1 NCR1 SPP1 SPP1 ECSIT ECSIT CXCR4 CXCR4 ULK1 ULK1 IRF3 IRF3 OAS1 OAS1 OAS3 OAS3 TLR7 TLR7 TLR8 TLR8 TRAF3 TRAF3 MYD88 MYD88 BCR BCR CD34 CD34 IL18 IL18 CGAS CGAS TMPRSS4 TMPRSS4 CCL19 CCL19 CCL21 CCL21 M3Y0H1_MUSPF M3Y0H1_MUSPF CD274 CD274 JAK2 JAK2 TLE3 TLE3 ATG7 ATG7 IL22 IL22 TBK1 TBK1 CD40 CD40 S1PR1 S1PR1 CCR8 CCR8 IFNG-2 IFNG-2 IFNB1 IFNB1 SOCS3 SOCS3 RAG1 RAG1 CXCR3 CXCR3 TLE1 TLE1 TRAF6 TRAF6 HMOX1 HMOX1 TLE4 TLE4 CD19 CD19 OSM OSM SPHK1 SPHK1 IL6 IL6 ISG15 ISG15 TAOK1 TAOK1 FOXP3 FOXP3 MAP1B MAP1B ARG1 ARG1 CCR7 CCR7 TNFAIP3 TNFAIP3 CCL5 CCL5 ACE ACE CCR2 CCR2 FASLG FASLG FURIN FURIN C1R C1R C1S C1S CD4 CD4 CD27 CD27 LTBR LTBR VWF VWF GOT1 GOT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TIGITT cell immunoreceptor with Ig and ITIM domains. (245 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
NLRX1NLR family member X1. (975 aa)
ATG14Autophagy related 14. (467 aa)
APOEApolipoprotein E. (322 aa)
TNFSF14TNF superfamily member 14; Belongs to the tumor necrosis factor family. (241 aa)
IL6RInterleukin 6 receptor. (436 aa)
IL11Interleukin 11. (197 aa)
IRF4Interferon regulatory factor 4. (451 aa)
CXCL11C-X-C motif chemokine. (132 aa)
CXCL10C-X-C motif chemokine. (98 aa)
MAVSMitochondrial antiviral signaling protein. (524 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (531 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (696 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
AREGAmphiregulin. (283 aa)
ICOSInducible T-cell co-stimulator. (209 aa)
GNLYSaposin B-type domain-containing protein. (163 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (265 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
IL10Interleukin 10. (220 aa)
IL7Interleukin 7. (158 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (132 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
KRT19Keratin 19; Belongs to the intermediate filament family. (404 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (764 aa)
LTBLymphotoxin beta; Belongs to the tumor necrosis factor family. (247 aa)
TNFTumor necrosis factor alpha; Belongs to the tumor necrosis factor family. (233 aa)
RNASELRibonuclease L. (726 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
RNF41Ring finger protein 41. (317 aa)
CCL20C-C motif chemokine. (97 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (339 aa)
NCR1Natural cytotoxicity triggering receptor 1. (281 aa)
SPP1Secreted phosphoprotein 1. (272 aa)
ECSITECSIT signalling integrator. (436 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
ULK1Unc-51 like autophagy activating kinase 1. (970 aa)
IRF3Interferon regulatory factor 3. (421 aa)
OAS12'-5'-oligoadenylate synthetase 1. (400 aa)
OAS32'-5'-oligoadenylate synthetase 3. (1230 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1083 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1087 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
BCRBCR activator of RhoGEF and GTPase. (1279 aa)
CD34CD34 molecule. (385 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
CGASCyclic GMP-AMP synthase. (526 aa)
TMPRSS4Transmembrane serine protease 4; Belongs to the peptidase S1 family. (436 aa)
CCL19C-C motif chemokine. (108 aa)
CCL21SCY domain-containing protein. (137 aa)
M3Y0H1_MUSPFAspartate aminotransferase. (430 aa)
CD274CD274 molecule. (303 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
TLE3TLE family member 3, transcriptional corepressor. (769 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (788 aa)
IL22Interleukin 22. (178 aa)
TBK1TANK-binding kinase 1. (729 aa)
CD40CD40 molecule. (277 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
CCR8C-C motif chemokine receptor 8; Belongs to the G-protein coupled receptor 1 family. (355 aa)
IFNG-2Uncharacterized protein. (187 aa)
IFNB1Interferon beta. (186 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa)
TLE1TLE family member 1, transcriptional corepressor. (771 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
TLE4TLE family member 4, transcriptional corepressor. (711 aa)
CD19CD19 molecule. (560 aa)
OSMOncostatin M. (238 aa)
SPHK1Sphingosine kinase 1. (386 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
ISG15ISG15 ubiquitin like modifier. (184 aa)
TAOK1TAO kinase 1. (1001 aa)
FOXP3Forkhead box P3. (433 aa)
MAP1BMicrotubule associated protein 1B. (2471 aa)
ARG1Arginase. (322 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
CCL5C-C motif chemokine. (91 aa)
ACEAngiotensin-converting enzyme. (1247 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (337 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (275 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (796 aa)
C1RComplement C1r; Belongs to the peptidase S1 family. (705 aa)
C1SComplement C1s; Belongs to the peptidase S1 family. (695 aa)
CD4CD4. (462 aa)
CD27CD27 molecule. (263 aa)
LTBRLymphotoxin beta receptor. (420 aa)
VWFVon Willebrand factor. (2814 aa)
GOT1Aspartate aminotransferase. (390 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
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