STRINGSTRING
STAT1 STAT1 IL6 IL6 ISG15 ISG15 FOXP3 FOXP3 IL15 IL15 TBK1 TBK1 EGFR EGFR TLR2 TLR2 STAT2 STAT2 IFNAR1 IFNAR1 JAK1 JAK1 TRAF6 TRAF6 RNASEL RNASEL TLR3 TLR3 IL1B IL1B ASGR1 ASGR1 IRF1 IRF1 STAT3 STAT3 IL10 IL10 MAVS MAVS CXCL10 CXCL10 TYK2 TYK2 TRADD TRADD NOD1 NOD1 GBP1 GBP1 TMEM134 TMEM134 IL18 IL18 NOD2 NOD2 TLR8 TLR8 TLR7 TLR7 OAS2 OAS2 OAS1 OAS1 IRF3 IRF3 TLR4 TLR4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STAT1Signal transducer and activator of transcription. (750 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
ISG15ISG15 ubiquitin like modifier. (184 aa)
FOXP3Forkhead box P3. (433 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
TBK1TANK-binding kinase 1. (729 aa)
EGFRReceptor protein-tyrosine kinase. (1207 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
STAT2Signal transducer and activator of transcription. (848 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (560 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
RNASELRibonuclease L. (726 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (764 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (168 aa)
ASGR1Asialoglycoprotein receptor 1. (290 aa)
IRF1Interferon regulatory factor. (322 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
IL10Interleukin 10. (220 aa)
MAVSMitochondrial antiviral signaling protein. (524 aa)
CXCL10C-X-C motif chemokine. (98 aa)
TYK2Tyrosine-protein kinase. (1182 aa)
TRADDTNFRSF1A associated via death domain. (314 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (952 aa)
GBP1Guanylate binding protein 1. (591 aa)
TMEM134Transmembrane protein 134. (195 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1013 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1087 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1083 aa)
OAS22'-5'-oligoadenylate synthetase 2. (685 aa)
OAS12'-5'-oligoadenylate synthetase 1. (400 aa)
IRF3Interferon regulatory factor 3. (421 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
Your Current Organism:
Mustela putorius
NCBI taxonomy Id: 9669
Other names: M. putorius furo, Mustela furo, Mustela putorius furo, black ferret, domestic ferret, ferret
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.